Pfizer, Moderna COVID-19 vaccines highly effective after first shot in real-world use, -U.S. study

By Ankur Banerjee and Vishwadha Chander

(Reuters) – COVID-19 vaccines developed by Pfizer Inc with BioNTech SE and Moderna Inc reduced the risk of infection by 80% two weeks or more after the first of two shots, according to data from a real-world U.S. study released on Monday.

The risk of infection fell 90% by two weeks after the second shot, the study of just under 4,000 vaccinated U.S. healthcare personnel and first responders found.

The study by the U.S. Centers for Disease Control and Prevention (CDC) evaluated the vaccines’ ability to protect against infection, including infections that did not cause symptoms. Previous clinical trials by the companies evaluated their vaccine’s efficacy in preventing illness from COVID-19.

The findings from of the real-world use of these messenger RNA (mRNA) vaccines confirm the efficacy demonstrated in the large controlled clinical trials conducted before they received emergency use authorizations from the U.S. Food and Drug Administration.

The study looked at the effectiveness of the mRNA vaccines among 3,950 participants in six states over a 13-week period from Dec. 14, 2020 to March 13, 2021.

“The authorized mRNA COVID-19 vaccines provided early, substantial real-world protection against infection for our nation’s healthcare personnel, first responders, and other frontline essential workers,” CDC Director Rochelle Walensky said in a statement.

The new mRNA technology is a synthetic form of a natural chemical messenger being used to instruct cells to make proteins that mirror part of the novel coronavirus. That teaches the immune system to recognize and attack the actual virus.

The CDC study comes weeks after real-world data from Israel suggested that the Pfizer/BioNTech vaccine was 94% effective in preventing asymptomatic infections.

Some countries, including Britain and Canada, are allowing extended gaps between doses that differ from how the vaccines were tested in clinical trials in order to alleviate supply constraints. In the trials, there was a three-week gap between Pfizer shots and four weeks for the Moderna vaccine.

In Britain, authorities said in January that data supported its decision to move to 12 weeks between the first and second Pfizer/BioNtech shots. Pfizer and its German partner have warned that they had no evidence to prove that.

(Reporting by Ankur Banerjee and Vishwadha Chander in Bengaluru; Editing by Peter Henderson and Bill Berkrot)

A year on from first lockdown, Britain grieves for COVID-19 dead

By Estelle Shirbon

LONDON (Reuters) – A year to the day after they were first ordered to stay at home to contain the spread of COVID-19, Britons on Tuesday remembered more than 126,000 people who lost their lives to the disease, a toll few people could have imagined in March 2020.

At midday (1200 GMT), people in parliament, hospitals, churches, public places and offices – still mostly empty with millions working at home due to social distancing rules – fell silent for a minute to honor the dead.

People were also being invited to stand on their doorsteps at 8 p.m. holding candles or torches.

Official data show that on March 23, 2020, when Prime Minister Boris Johnson stunned the nation by ordering people to stay at home and shutting down much of the economy, fewer than 1,000 Britons had succumbed to the novel coronavirus.

The number of people known to have died in the United Kingdom within 28 days of testing positive for COVID-19 now stands at 126,172, the worst toll in Europe and fifth highest in the world.

Johnson, who was himself very ill with COVID-19 in April 2020 and spent three nights in intensive care, opened Tuesday’s cabinet meeting by reflecting on “a very dark and difficult year” for Britain, his Downing Street office said.

Johnson told ministers the nation was mourning for those who have died, and he paid tribute to health and care workers and to society as a whole for keeping the country going.

Queen Elizabeth marked the anniversary by sending spring flowers to St. Bartholomew’s Hospital in London. Her husband, 99-year-old Prince Philip, underwent a heart procedure there earlier this month.

“As we look forward to a brighter future together, today we pause to reflect on the grief and loss that continues to be felt by so many people and families,” she said in a message.

HEARTS TO REMEMBER

In the evening, landmarks across the United Kingdom, from the London Eye, Trafalgar Square and Wembley Stadium to Cardiff Castle and Belfast City Hall will be lit up in yellow as a beacon of hope and support for the bereaved.

At Kew Gardens, the world-renowned botanical gardens in west London, two heart-shaped flower beds made up of yellow tulips, hyacinths and polyanthus were on display, in solidarity with the Yellow Hearts to Remember campaign to support the bereaved.

The past year has tested the country with repeated lockdowns, forced separation on families and friends and months of home schooling on millions of children and left industries fighting for survival.

After a second national lockdown kept people shut up in their homes through much of the winter, Britain is gradually easing restrictions under a four-step plan underpinned by the success of the national vaccination campaign.

Close to 28 million people have received at least one dose of a COVID-19 vaccine, offering hope of a gradual return to normality.

Johnson paid tribute to scientists, saying he would not have believed 12 months ago that within a year vaccines would have been developed and half Britain’s adult population would have received at least one dose.

For now, however, life remains far from normal.

During rush hour, a small number of London commuters – all wearing face masks – had space to sit down on their way to work, where before the pandemic thousands of people would have been crammed together.

“It’s been a struggle, I’m not going to lie,” said Londoner Tom Johnson on his commute.

“We can sort of see a light at the end of the tunnel now,” he added. “I think we’re quite a strong, resilient sort of country, and I reckon we’ll come back flying.”

(Additional reporting by Toby Melville and Ben Makori; editing by Ed Osmond and Mike Collett-White)

Britain to expand nuclear warhead stockpile by over 40% as global threats rise

LONDON (Reuters) – Britain will grow its nuclear warhead stockpile by more than 40% to ensure its security in a more risky global environment and as it faces new technological threats, Prime Minister Boris Johnson said on Tuesday.

The country had previously been reducing its nuclear weapons stockpile, and in 2010, the government set a cap of 180 warheads for the mid-2020 period. Johnson scrapped the earlier limit and said the number would now rise to a maximum of 260.

In its security and defense review, Britain said it faced risks from nuclear-armed states, emerging nuclear states and state-sponsored nuclear terrorism, and its nuclear deterrent was needed to guarantee its security and that of its allies.

“Some states are now significantly increasing and diversifying their nuclear arsenals,” the government said. “The increase in global competition, challenges to the international order, and proliferation of potentially disruptive technologies all pose a threat to strategic stability.”

The move was criticized by The Elders, a group of former global policymakers who campaign for peace.

“While the UK cites increased security threats as justification for this move, the appropriate response to these challenges should be to work multilaterally to strengthen international arms control agreements and to reduce – not increase – the number of nuclear weapons in existence,” said Mary Robinson, chair of the group.

Questioned over the policy in parliament Johnson said Britain was still committed to global nuclear arms reduction.

Britain also said it planned to replace its current nuclear warhead with a new one which would be able to operate throughout the lifespan of four new submarines being built and due to enter service in the early 2030s.

It will work with the United States to ensure the new warhead remains Trident-compatible.

With its current submarines, Britain said it would stick to its existing policy of always having one submarine of its four nuclear deterrent submarines on continuous patrol.

(Reporting by Sarah Young, additional reporting by William James, editing by Elizabeth Piper)

Britain urges citizens to leave Myanmar as violence against protesters mounts

(Reuters) – Britain urged its citizens to leave Myanmar on Friday as security forces cracked down on more protests against the junta, forcing patients out of a hospital in the west of the country and arresting a Polish journalist.

After 12 people were killed on Thursday in one of the bloodiest days since the Feb. 1 coup, the British foreign office warned that “political tension and unrest are widespread since the military takeover and levels of violence are rising”.

Friday’s protests came as South Korea said it would suspend defense exchanges and reconsider development aid to Myanmar because of the violence.

More than 70 protesters have now been killed in the Southeast Asian nation since the military seized power, the Assistance Association for Political Prisoners (AAPP) advocacy group said.

Memorials were held for some of them on Friday, including one man whose family said his body had been taken by the security forces and not returned.

A spokesman for the junta did not answer phone calls from Reuters seeking comment.

“Despite repeated demands of the international community, including South Korea, there are an increasing number of victims in Myanmar due to violent acts of the military and police authorities,” South Korea’s foreign ministry said in a statement.

It said Seoul would suspend defense exchanges, ban arms exports, limit exports of other strategic items, reconsider development aid and grant humanitarian exemptions allowing Myanmar nationals to stay in South Korea until the situation improved.

Protests were held in Yangon, Myanmar’s biggest city, and several other towns on Friday, photographs posted on social media by witnesses and news organizations showed. Many were dispersed by security forces.

Poland’s foreign ministry said a Polish journalist was arrested, the second foreign reporter to be detained. A Japanese journalist was briefly held while covering a protest.

Riot police and armed soldiers entered the general hospital in Hakha, in the western Chin state, forcing all 30 patients to leave and evicting staff from on-site housing, said local activist Salai Lian.

Soldiers have been occupying hospitals and universities across Myanmar as they try to quash a civil disobedience movement that started with government employees like doctors and teachers but has expanded into a general strike that has paralyzed many sectors of the economy.

The country has been in crisis since the army ousted Aung San Suu Kyi’s elected government last month, detained her and officials of her National League for Democracy party, and set up a ruling junta of generals.

Junta spokesman Brigadier General Zaw Min Tun said on Thursday Suu Kyi had accepted gold and illegal payments worth $600,000 while in government. He said Phyo Min Thein, a former chief minister of Yangon, who is also in jail, had admitted making the payments.

Adding corruption charges to the accusations facing Suu Kyi, 75, could bring her a harsher penalty. The Nobel Peace Prize laureate currently faces four comparatively minor charges, such as illegally importing six walkie-talkie radios and flouting coronavirus curbs.

“This accusation is the most hilarious joke,” Suu Kyi’s lawyer Khin Maung Zaw said on social media on Friday. “She might have other weaknesses but she doesn’t have weakness in moral principle.”

‘CRIMES AGAINST HUMANITY’

Thursday’s dead included eight people killed when security forces fired on a protest in the central town of Myaing, the AAPP said.

Chit Min Thu was killed in the North Dagon district of Yangon. His wife, Aye Myat Thu, told Reuters he had insisted on joining the protests despite her appeals that he stay at home for the sake of their son.

“He said it’s worth dying for,” she said through her tears. “He is worried about people not joining the protest. If so, democracy will not return.”

The bloodshed came hours after the U.N. Security Council had called for restraint from the army.

U.N. human rights investigator Thomas Andrews on Friday dismissed as “absurd” comments by a senior Myanmar official that authorities were exercising “utmost restraint”. Addressing the U.N. Human Rights Council in Geneva, he called for a united approach to “strip away the junta’s sense of impunity.”

The army did not respond to requests for comment on the latest deaths, but junta spokesman Zaw Min Tun said on Thursday the security forces were disciplined and used force only when necessary.

Rights group Amnesty International accused the army of using lethal force against protesters and said many killings it had documented amounted to extra-judicial executions.

Suu Kyi fought for decades to overturn military rule under previous juntas before tentative democratic reforms began in 2011. She had spent a total of about 15 years under house arrest.

The army has justified taking power by saying that a November election, overwhelmingly won by Suu Kyi’s party, was marred by fraud – an assertion rejected by the electoral commission.

The junta has said a state of emergency will last for a year, but has not set a date for the election.

(Reporting by Reuters staff; Writing by Ed Davies and Raju Gopalakrishnan; Editing by Lincoln Feast, Clarence Fernandez and Catherine Evans)

COVID variant ‘taking over’ UK and likely to dominate elsewhere: expert

By Kate Kelland

LONDON (Reuters) – A coronavirus variant first found a few months ago in Britain is now “taking over” and causing 98% of all cases in the UK, the scientist leading the country’s variant-tracking research said on Thursday.

Sharon Peacock said the UK variant, known as B.1.1.7, also appears to be gaining a firm grip in many of the 100 or so other countries it has spread to in the past few months.

“It’s around 50% more transmissible – hence its success in really taking over the country,” said Peacock, director of the COVID-19 Genomics UK (COG-UK) consortium of scientists monitoring mutations in the coronavirus.

“We now know that it has spread across the UK and causes nearly all of the cases of COVID-19 – about 98%,” she told an online briefing for Britain’s Royal Society of Medicine.

“It appears to be the case that the other variants are not getting a foothold in this country.”

The B.1.1.7 variant, first detected in September 2020, has 23 mutations in its genetic code – a relatively high number of changes – and is thought by experts to be 40%-70% more transmissible than previously dominant variants.

Peacock also noted data released on Wednesday from a UK study which found that B.1.1.7 has “significantly higher” mortality, with death rates among those infected with it between 30% and 100% greater than among those infected with previous variants.

“There is a small increase in the likelihood of death from the variant,” she said.

The World Health Organization says B.1.1.7 is one of several “variants of concern,” along with others that have emerged in South Africa and Brazil. The variants are mutant versions of the SARS-CoV-2 virus that causes COVID-19, which has already killed more than 2.7 million people in the pandemic.

B.1.1.7 has spread to about 100 countries, according to WHO data, and some of those, including France, Denmark and the United States, have reported swift rises in the proportion of their COVID-19 cases being caused by it.

Peacock said evidence from the UK suggests B.1.1.7. is likely to become dominant elsewhere too.

“Because of its transmissibility, once it’s introduced, it does have that advantage over other circulating variants – so it is the case that B.1.1.7 appears to be travelling around the world and really expanding where it lands.”

Public Health England (PHE) also said on Thursday that a new coronavirus variant had been identified in the UK in two people who had recently been in Antigua. PHE said it shared some traits of other variants but was not classed as concerning for now.

(Reporting by Kate Kelland, Editing by William Maclean)

“Bounce back better together:” PM Johnson urges Britons to lose weight

LONDON (Reuters) – “We’ll bounce back better together,” Prime Minister Boris Johnson told overweight Britons on Thursday, championing his own weight loss and healthy eating diet to try to persuade others to get in shape to reduce coronavirus risks.

After being hospitalized with COVID last year, Johnson has often spoken about how he believes his weight was behind how severely ill he became and how since then he has started a new exercise regime and no late-night cheese diet.

Evidence emerging around the world suggests that people who are overweight or obese are at increased risk of getting more severely ill with COVID-19.

“I’ve been doing a lot, in fact everything I can, to lose weight and to feel fitter and healthier. And what I’ve been doing is I’ve been eating less carbs, avoiding chocolate, no more late night cheese, I’ve been getting up early to go for runs and the result is that I actually have lost some weight,” he said on Twitter, unveiling a new scheme to get people fitter.

“What we want to do is encourage another 700,000 people around the country who have the kind of problems that I have had to do the same thing, so we’ll be not just fitter but also healthier and happier and we’ll bounce back better together.”

The government, he said, would spend 100 million pounds to help people to access doctors’ appointments, access the right Apps to help with weight loss and that it was looking at what he called fit miles schemes as well.

His press secretary, Allegra Stratton, told reporters the British leader had lost most probably more than the 14 pounds (6 kilograms), or a stone, he talks about as she believed he was being modest, adding that he takes his diet “very seriously.”

Asked if he had given up drinking alcohol, Stratton said she wasn’t sure if he had cut it out completely. “He certainly was offered a drink yesterday and said no, no I am not drinking at the moment.”

(Reporting by Elizabeth Piper, editing by Andy Bruce)

UK to prioritize next stage of COVID-19 vaccines by age, not job

By Alistair Smout

LONDON (Reuters) – Police and teachers will not jump to the head of the queue in the second phase of Britain’s COVID-19 vaccination rollout, with people instead prioritized by age, officials advising the government said on Friday, describing this as the best way to keep up the pace of immunizations.

Britain’s vaccine program has been among the fastest in the world, meeting a government target to offer a first dose of vaccination to 15 million high-risk people by mid-February.

Some frontline workers such as police and teachers had been calling for prioritization on the basis of their jobs, but Professor Wei Shen Lim, COVID-19 chairman for the Joint Committee on Vaccination and Immunization (JCVI), said such an approach could complicate the rollout.

“Following an age-based program will be simple, and simplicity has been one of the cornerstones of the current program in terms of speed and its success,” he told a news conference.

Britain aims to complete the first phase of its vaccine rollout by mid-April.

While the priority list for that phase was largely determined by age, with all over-50s set to be offered a vaccine, health and care workers and clinically vulnerable people have also been prioritized.

Announcing the prioritization list for phase 2, Lim said all those aged between 40-49 would be next in line for the shot, then those aged 30-39, then those aged 18-29.

The JCVI said that an age-based approach remained the most effective way of reducing death and hospitalization from COVID-19, even in those under 50. Giving shots by job would be logistically complex and could result in delays, it said.

The government said it would follow the recommended approach, but not everyone welcomed the advice.

John Apter, chairman of the Police Federation of England & Wales, said it was “a contemptible betrayal of police officers.”

“Their anger is palpable, this will not be forgotten.”

(Reporting by Alistair Smout; Editing by Michael Holden, Elizabeth Piper and Frances Kerry)

Philippines offers nurses in exchange for vaccines from Britain, Germany

By Neil Jerome Morales

MANILA (Reuters) – The Philippines will let thousands of its healthcare workers, mostly nurses, take up jobs in Britain and Germany if the two countries agree to donate much-needed coronavirus vaccines, a senior official said on Tuesday.

The Philippines, which has among Asia’s highest number of coronavirus cases, has relaxed a ban on deploying its healthcare workers overseas, but still limits the number of medical professionals leaving the country to 5,000 a year.

Alice Visperas, director of the labor ministry’s international affairs bureau, said the Philippines was open to lifting the cap in exchange for vaccines from Britain and Germany, which it would use to inoculate outbound workers and hundreds of thousands of Filipino repatriates.

Nurses are among the millions of Filipinos who work overseas, providing in excess of $30 billion a year in remittances vital to the country’s economy.

“We are considering the request to lift the deployment cap, subject to agreement,” Visperas told Reuters.

Britain is grappling with the world’s sixth-highest coronavirus death toll and one of the worst economic hits from the pandemic, while Germany has the 10th most infections globally.

While the two countries have inoculated a combined 23 million people, the Philippines has yet to start its campaign to immunize 70 million adults, or two-thirds of its 108 million people. It expects to receive its first batch of vaccines this week, donated by China.

The Philippines wants to secure 148 million doses of vaccines altogether.

The British embassy in Manila did not immediately respond to a request for comment while calls to Germany’s mission went unanswered.

In 2019, almost 17,000 Filipino nurses signed overseas work contracts, government data showed.

While Filipino nurses have fought to lift the deployment ban to escape poor working conditions and low pay at home, the workers-for-vaccine plan has not gone down well with some medical workers.

“We are disgusted on how nurses and healthcare workers are being treated by the government as commodities or export products,” Jocelyn Andamo, secretary general of the Filipino Nurses United, told Reuters.

Britain tightens travel restrictions with hotel quarantine and prison threat

By Sarah Young

LONDON (Reuters) – Britain will require passengers arriving from countries where worrying coronavirus variants are spreading to pay for 10 days of quarantine in hotels, while rule-breakers will face heavy fines or jail terms, under tighter restrictions from next week.

The new travel rules add to restrictions that already ban travel abroad for holidays. The government said the stronger measures were needed to prevent new variants of the virus from thwarting Britain’s rapid vaccination program.

Airlines and travel companies called for more government aid, saying the new rules would deepen a crisis that has seen them lose nearly all their revenue.

Health secretary Matt Hancock said people could be sent to prison and fined up to 10,000 pounds ($14,000) if they break the rules which come into force on Feb. 15.

“Anyone who lies on the passenger locator form and tries to conceal that they’ve been in a country on the ‘red list’ in the 10 days before arrival here, will face a prison sentence of up to 10 years,” Hancock told parliament.

British and Irish nationals arriving in England who have been in high risk countries in the last 10 days would be required to pay 1,750 pounds ($2,400) to cover the cost of a minimum 10-day quarantine in a designated hotel, Hancock said.

All arrivals into the UK will also have to take further COVID-19 tests on day 2 and day 8 of their quarantines, he said, on top of a pre-departure test already required.

Britain has rolled out the fastest vaccination program of any large country. But there has been alarm in recent days after reports that the vaccines it is using may be less effective against some new variants of the virus, such as one that has spread rapidly in South Africa.

NO END IN SIGHT

The government, criticized in recent weeks for being slow to bring in tougher border measures, said the stricter rules could stay in place until it is sure vaccines work against new variants, or booster shots become available.

“Strong protections at the border are part of defending and safely allowing the domestic opening up,” Hancock said.

British airlines and airports issued a new cry for help, the latest of many, urging the government to provide more support to make sure the sector makes it through the year, and to issue a roadmap on how it will ease restrictions.

“Airports and airlines are battling to survive with almost zero revenue and a huge cost base, and practically every week a further blow lands,” aviation trade bodies said.

Hancock said the measures could not be in place permanently and would be replaced “over time with a system of safe and free international travel”.

The government said it had contracted 16 hotels for an initial 4,600 rooms for hotel quarantine and would secure more as needed, with further details due to be published on Thursday.

Quarantines in hotels have been used by Australia and New Zealand as a strategy to sharply limit the spread of the coronavirus.

($1 = 0.7259 pounds)

(Reporting by Guy Faulconbridge and Kate Holton, additional reporting by Andrew MacAskill, Editing by Paul Sandle, Michael Holden, Giles Elgood, Peter Graff)

UK’s record-breaking fundraiser, ‘hero’ Captain Tom Moore, dies aged 100

By Ben Makori and Henry Nicholls

MARSTON MORETAINE, England (Reuters) -Britain’s Captain Tom Moore, the World War Two veteran who lifted a nation’s spirits by raising millions of pounds for health service workers battling the coronavirus, died on Tuesday aged 100 after he contracted COVID-19.

Moore struck a chord with locked-down Britain by walking around his garden with the help of a frame to raise 38.9 million pounds ($53 million) for the National Health Service.

His endeavor and wit spread joy amid the grim news of the coronavirus outbreak: Moore’s message to the world was that the sun would shine again and that the clouds would clear.

“It is with great sadness that we announce the death of our dear father, Captain Sir Tom Moore,” his daughters said in a statement following his death on Tuesday morning at Bedford Hospital in central England.

Over the last five years, he had been receiving treatment for prostate and skin cancer, his family said. He was fighting pneumonia and was taken to hospital after testing positive for COVID-19 on Jan. 22, unable to be vaccinated due to the other medication he was taking.

British Prime Minister Boris Johnson and Queen Elizabeth led the tributes to Moore, whose exploits won global admiration.

“Captain Tom Moore was a hero in the truest sense of the word,” said Johnson, who spoke to Moore’s daughter Hannah to pass on his condolences. “He became not just a national inspiration but a beacon of hope for the world.”

The flag above his Downing Street office was lowered to half-mast in Moore’s honor.

The queen, who knighted Moore at Windsor Castle last summer in recognition of his efforts, will send a message of private condolence to the family, Buckingham Palace said, adding the 94-year-old monarch had “very much enjoyed meeting Captain Sir Tom”.

“Her thoughts, and those of the Royal Family, are with them, recognizing the inspiration he provided for the whole nation and others across the world,” the palace said.

When Moore, dressed in a blazer and tie, started his sponsored walk at his home in the village of Marston Moretaine, 80km (50 miles) north of London, he hoped to raise 1,000 pounds.

Instead, he amassed a world record sum for the National Health Service, with his quiet determination and cheerful outlook winning the hearts of the British public.

SUNSHINE DURING LOCKDOWN

“The last year of our father’s life was nothing short of remarkable. He was rejuvenated and experienced things he’d only ever dreamed of,” his daughters said.

“Whilst he’d been in so many hearts for just a short time, he was an incredible father and grandfather, and he will stay alive in our hearts forever.”

Such was his fame that his 100th birthday was marked by a message from Johnson, a promotion to the rank of colonel and fly pasts by both historic planes and modern RAF helicopters above his home.

He received more than 125,000 birthday cards from well-wishers around the world and became the oldest person to reach number one in Britain’s main music singles chart, featuring on a cover version of “You’ll Never Walk Alone”.

“I never, ever anticipated ever in my life anything like this, it really is amazing,” Moore said when he turned 100 on April 30. “Thank you very much to everyone, wherever you are.”

Raised in Yorkshire, northern England, Moore served in India, Burma and Sumatra during World War Two.

Soldiers from the First Battalion of the Yorkshire Regiment, the successor to his own, gave him a guard of honor when he completed the 100th length of the garden on April 16, 2020.

Moore found words to cheer up the British public during lockdown, his status as a war veteran adding to his standing.

“For all those people who are finding it difficult at the moment, the sun will shine on you again and the clouds will go away,” he said after completing his sponsored walk.

“You’ve all got to remember that we will get through it in the end, it will all be right, it might take time. At the end of the day we shall all be OK again.”

($1 = 0.7334 pounds)

(Writing by Guy Faulconbridge and Michael Holden; additional reporting by Estelle Shirbon and Costas Pitas in London; Editing by Mike Collett-White)