Tag Archives: Coronavirus

COVID-19 may damage bone marrow immune cells; another reinfection reported

By Nancy Lapid

(Reuters) – The following is a roundup of some of the latest scientific studies on the novel coronavirus and efforts to find treatments and vaccines for COVID-19, the illness caused by the virus.

COVID-19 may damage immune cells in the bone marrow

Even bone marrow may not be a safe harbor from the ravages of COVID-19, according to a study that found previously unrecognized changes in newly produced immune cells, called monocytes, released into the blood from bone marrow. To learn more about how the body responds to COVID-19, researchers obtained serial “snapshots” of patients’ immune health by analyzing their immune cells at multiple points during their hospital stays. In COVID-19 patients with more severe disease, the monocytes do not function properly, researchers reported last week in Science Immunology. It was not yet clear whether the monocytes are being released from the bone marrow in an altered state or whether the alterations happen after monocytes enter the blood, coauthor Tracy Hussell of the University of Manchester in the UK told Reuters. Either way, she said, treatments that prevent their release from the bone marrow may help reduce the exaggerated immune response that contributes to poor outcomes in patients with severe COVID-19.

COVID-19 reinfections occur, but remain rare

Another case of reinfection after recovery from COVID-19 has been reported, this time in a healthy young military healthcare provider at a U.S. Department of Defense hospital in Virginia. He was first infected by a patient in March. He recovered within 10 days and “returned … to excellent health,” his doctors reported on Saturday in Clinical Infectious Diseases. Fifty-one days later, he was reinfected by a household member. Genetic studies showed the first and second infections to be from slightly different strains of the virus. The reinfection made him sicker, perhaps because the second strain was more potent, or the household contact infected him with a higher load of virus, doctors said. It was also possible antibodies from the first infection may have triggered his immune system to respond more strongly to the virus the second time his body encountered it. COVID-19 reinfections are still rare, they said. Kristian Anderson, professor of immunology and microbiology at Scripps Research in La Jolla, California, recently told Reuters virus reinfections are always possible. “We don’t know at what frequency reinfections (with the new coronavirus) occur and how that might change over time,” Anderson said. Without further studies, “we can’t conclude what a single case of reinfection means for longevity and robustness of COVID-19 immunity and relevance for a future vaccine,” she added.

Proven immunotherapy approach might be possible in COVID-19

A proven approach to severe virus infections, known as cytotoxic T cell therapy, may be applicable to COVID-19 despite a potential hurdle, researchers said. The approach involves treating critically ill patients with infusions of key immune cells known as T-lymphocytes obtained from people who successfully fought off the same virus. These donor T cells have learned to recognize and target the invading virus. But steroids, which are being increasingly used to treat COVID-19 patients, are toxic to lymphocytes, likely canceling out any beneficial effects of the immunotherapy. In a new report posted on bioRxiv ahead of peer review, researchers describe a possible workaround. They say they have figured out a way to take donor T cells that target the novel coronavirus and make them resistant to the deadly effects of steroids. “We are currently working on … developing clinical trials to determine safety and efficacy,” coauthor Dr. Katy Rezvani of The University of Texas MD Anderson Cancer Center told Reuters.

High COVID-19 mortality seen in assisted-living facilities

Data compiled from more than 4,600 assisted living facilities in seven U.S. states through the end of May showed a four-fold higher COVID-19 fatality rate than in the nearby communities, researchers reported on Monday in the Journal of the American Geriatric Society. In North Carolina and Connecticut, for example, the proportions of COVID-19 cases that were fatal across the state were 3.3% and 9.3%, respectively. In assisted living facilities in those states, the fatality rate climbed to 13% and 31.6%. Unlike nursing homes, assisted living communities are not subject to federal regulation and are not required to collect and report data on COVID-19, coauthor Helena Temkin-Greener of the University of Rochester School of Medicine & Dentistry said in a news release. In this study, and in a separate study of nursing homes her team published on Monday in the same journal, COVID-19 cases were more common in facilities with more minority residents and more residents with dementia, chronic obstructive pulmonary disease, and obesity. “Assisted living communities and their residents urgently need local, state, and the federal governments to pay at least the same level of attention as that given to nursing homes,” Temkin-Greener and colleagues conclude.

(Reporting by Nancy Lapid and Deena Beasley; Editing by Bill Berkrot)

U.S. surpasses grim milestone of 200,000 COVID-19 deaths

By Sangameswaran S

(Reuters) – The death toll from the spread of the coronavirus in the United States exceeded 200,000 on Tuesday, by the far the highest number of any nation.

The United States, on a weekly average, is now losing about 800 lives each day to the virus, according to a Reuters tally. That is down from a peak of 2,806 daily deaths recorded on April 15.

During the early months of the pandemic, 200,000 deaths was regarded by many as the maximum number of lives likely to be lost in the United States to the virus.

The University of Washington’s health institute is forecasting coronavirus fatalities reaching 378,000 by the end of 2020, with the daily death toll skyrocketing to 3,000 per day in December.

Over 70% of those in the United States who have lost their lives to the virus were over the age of 65, according to CDC data.

The southern states of Texas and Florida contributed the most deaths in the United States in the past two weeks and were closely followed by California.

California, Texas and Florida – the three most populous U.S. states – have recorded the most coronavirus infections and have long surpassed the state of New York, which was the epicenter of the outbreak in early 2020. The country as a whole is reporting over 42,000 new infections on average each day and saw cases last week rise on a weekly basis after falling for eight weeks in a row.

Deaths rose 5% last week after falling for four weeks in a row, according to a Reuters analysis.

Six out of every 10,000 residents in the United States has died of the virus, according to Reuters data, one of the highest rates among developed nations.

Brazil follows the United States in the number of overall deaths due to the virus, with over 137,000 fatalities. India has had the world’s highest daily death rate over the last week with total deaths now approaching 100,000.

(Reporting by Sangameswaran S in Bengaluru; Additional reporting by Susan Heavey in Washington; Editing by Lisa Shumaker and Rosalba O’Brien)

New U.S. COVID-19 cases rise 17% in past week, deaths up 5%

(Reuters) – The weekly number of new COVID-19 cases in the United States rose last week for the first time after falling for eight straight weeks, an increase that health experts attributed to schools reopening and parties over the Labor Day holiday.

New cases rose 17% to about 287,000 for the week ended Sept. 20, while deaths rose 5.5% to about 5,400 people after falling for the previous four weeks, according to a Reuters analysis of state and county reports.

Thirteen states have seen weekly infections rise for at least two weeks, up from nine states the previous week, according to the Reuters tally. In Arizona, new cases doubled last week.

On average, more than 776 people a day died from COVID-19 last week, with deaths rising in Arkansas, Kansas and Virginia.

After weeks of declining test rates, an average of 812,000 people a day were tested last week. The country set a record of testing over 1 million people on Saturday.

Nationally, the share of all tests that came back positive for COVID-19 fell for a seventh week to 5.0%, well below a recent peak of nearly 9% in mid-July, according to data from The COVID Tracking Project, a volunteer-run effort to track the outbreak.

However, 26 of the 50 states still have positive test rates above the 5% level that the World Health Organization considers concerning. The highest positive test rates are in the Midwest at over 16% in Idaho, Wisconsin, Iowa and South Dakota.

(Writing by Lisa Shumaker; Graphic by Chris Canipe; Editing by Tiffany Wu)

U.S. CDC reports 199,024 coronavirus deaths

(Reuters) – The U.S. Centers for Disease Control and Prevention (CDC) on Monday reported 6,786,352 cases of the new coronavirus, an increase of 37,417 cases from its previous count, and said that the number of deaths had risen by 270 to 199,024.

The CDC reported its tally of cases of the respiratory illness known as COVID-19, caused by the new coronavirus, as of 4 pm ET on Sept. 20 versus its previous report a day earlier.

The CDC figures do not necessarily reflect cases reported by individual states.

(Reporting by Manojna Maddipatla in Bengaluru; Editing by Aditya Soni)

Royal Caribbean, Norwegian Cruise submit health protocols to CDC looking to set sail again

By Nivedita Balu and Helen Coster

(Reuters) – Hoping to set sail again after a long halt due to the COVID-19 pandemic, Royal Caribbean Group and Norwegian Cruise Line Holdings Ltd. said on Monday they submitted a report to the U.S. Centers for Disease Control and Prevention (CDC) detailing health and safety protocols.

The cruise operators detailed 74 steps, including enhanced sanitation practices, controlling shore excursions and better protection for crew members, to protect guests once cruises resume.

Recommendations also include rigorous screening and testing before boarding and plans to address positive infection on board, the companies said.

In an interview with Reuters on Monday, which included the two cruise line chief executives and other members of a panel that developed the guidelines, Norwegian Chief Executive Frank Del Rio said he did not know how much Norwegian would need to pay to implement the panel’s recommendations.

“Put it in context, this is a drop in the bucket,” Del Rio said. “Whatever the number is, and I truly don’t know what it is and I don’t think [Royal Caribbean CEO] Richard [Fain] does either. We are at a zero revenue environment. This is a necessary step to return to service and we’re not really concerned about what the costs are.”

In July, the two companies announced a joint task force to help develop safety standards for restarting their businesses during the coronavirus pandemic.

The cruise industry has taken a major hit from the pandemic, with some of the earliest large clusters of COVID-19 occurring aboard cruise ships.

The CDC first issued a no-sail order on March 14 for all cruise ships and has been extending it since.

Cruise operators have lost about half to two-thirds of their value so far this year. Their shares were last down between 4% and 6% as worries of a second lockdown amid rising coronavirus cases shook broader markets.

(Reporting by Helen Coster in New York and Nivedita Balu in Bengaluru; Editing by Vinay Dwivedi and Dan Grebler)

Factbox: Latest on the worldwide spread of coronavirus

(Reuters) – Coronavirus infections slowed in Australia and New Zealand, while Britain said it was at a “tipping point” on COVID-19 as European countries mulled tightening restrictions to curb a sharp resurgence in cases.

EUROPE

* Britain is at a tipping point on COVID-19, health minister Matt Hancock said, warning that a second national lockdown could be imposed if people don’t follow government rules designed to stop the spread of the virus.

* The Czech government could declare a state of emergency if a recent spike in cases continues in the coming days, Health Minister Adam Vojtech said.

* Protesters in some poorer areas of Madrid that are facing a lockdown to stem a soaring infection rate took to the streets on Sunday to call for better health provisions, complaining of discrimination by the authorities.

* Russia reported 6,148 new cases on Sunday, the second straight day when the daily number of cases exceeded 6,000.

* French health authorities reported 10,569 new confirmed COVID-19 cases on Sunday, down from the previous day’s record increase of 13,498.

ASIA-PACIFIC

* Schools in Seoul and nearby areas resumed in-person classes for the first time in almost a month after daily cases dropped to the lowest levels since mid-August.

* Australia’s coronavirus hotspot of Victoria reported on Monday its lowest daily rise in infections in three months, although state Premier Daniel Andrews said there were no plans yet to ease restrictions sooner than expected.

* New Zealand Prime Minister Jacinda Ardern lifted all coronavirus restrictions across the country, except in second-wave hotspot Auckland, as the number of new infections slowed to a trickle.

AMERICAS

* The United States set a one-day record with over 1 million coronavirus diagnostic tests being performed, but the country needs 6 million to 10 million a day to bring outbreaks under control, according to various experts.

* Brazil and Argentina, Latin American nations seeking more time to commit to the global COVID-19 vaccine facility known as COVAX, said they intend to do so as soon as possible after missing Friday’s deadline.

MIDDLE EAST AND AFRICA

* Morocco signed a deal with Russia’s R-Pharm to buy a COVID-19 vaccine produced under a license from Britain’s AstraZeneca, the health ministry said, as its total number of cases approached 100,000.

* Israel entered a second nationwide lockdown at the onset of the Jewish high-holiday season, forcing residents to stay mostly at home amid a resurgence in new cases.

MEDICAL DEVELOPMENTS

* Moderna Inc said it was on track to produce 20 million doses of its experimental coronavirus vaccine by the end of the year, while maintaining its goal of readying 500 million to 1 billion doses in 2021.

ECONOMIC IMPACT

* British manufacturers see no evidence of a ‘V’-shaped recovery from the pandemic underway and many are planning to slash investment, a business survey showed.

(Compiled by Devika Syamnath and Alex Richardson; Edited by Shounak Dasgupta)

U.S. to surpass grim milestone of 200,000 COVID-19 deaths

By Sangameswaran S

(Reuters) – The death toll from the spread of coronavirus in the United States was approaching over 200,000 lives on Monday, more than double the number of fatalities in India, the country reporting the second-highest number of cases in the world.

The United States, on a weekly average, is now losing about 800 lives each day to the virus, according to a Reuters tally. That is down from a peak of 2,806 daily deaths recorded on April 15.

During the early months of the pandemic, 200,000 deaths was regarded by many as the maximum number of lives likely to be lost in the United States to the virus.

U.S. Centers for Disease Control and Prevention (CDC) Director Robert Redfield recently told Congress that a face mask would provide more guaranteed protection than a vaccine, which would only be broadly available by “late second quarter, third quarter 2021.”

The CDC currently predicts that the U.S. death toll will reach as high as 218,000 by Oct. 10.

The University of Washington’s health institute is forecasting coronavirus fatalities reaching 378,000 by the end of 2020, with the daily death toll skyrocketing to 3,000 per day in December.

Over 70% of those in the United States who have lost their lives to the virus were over the age of 65, according to CDC data.

The southern states of Texas and Florida contributed the most deaths in the United States in the past two weeks and was closely followed by California.

California, Texas and Florida – the three most populous U.S. states – have recorded the most coronavirus infections and have long surpassed the state of New York, which was the epicenter of the outbreak in early 2020. The country as a whole is reporting over 40,000 new infections on average each day.

As it battles a second wave of infections, the United States reported a 17% increase in the number of new cases last week compared with the previous seven days, with deaths rising 7% on average in the last, according to a Reuters analysis.

Six out of every 10,000 residents in the United States has died of the virus, according to Reuters data, one of the highest rates among developed nations.

Brazil follows the United States in the number of overall deaths due to the virus, with over 136,000 fatalities.

(Reporting by Sangameswaran S in Bengaluru; Editing by Lisa Shumaker and Rosalba O’Brien)

Second UK lockdown? PM says second wave inevitable, new restrictions possible

By Guy Faulconbridge, Kate Holton and Andy Bruce

LONDON (Reuters) – British Prime Minister Boris Johnson said he did not want another national lockdown but that new restrictions may be needed because the country was facing an “inevitable” second wave of COVID-19.

Ministers were on Friday reported to be considering a second national lockdown, after new COVID-19 cases almost doubled to 6,000 per day, hospital admissions rose and infection rates soared across parts of northern England and London.

That rise in cases was part of a second wave that was now unstoppable, the prime minister said.

“We are now seeing a second wave coming in…It is absolutely, I’m afraid, inevitable, that we will see it in this country,” Johnson told UK media.

Asked about whether the whole of the country should brace for a new lockdown, rather than just local restrictions, he said: “I don’t want to get into a second national lockdown at all.”

But he did not rule out further national restrictions being brought in.

“When you look at what is happening, you’ve got to wonder whether we need to go further than the rule of six that we brought in on Monday,” he said, referring to the ban on gatherings of more than six people.

The United Kingdom has reported the fifth largest number of deaths from COVID-19 in the world, after the United States, Brazil, India and Mexico, according to data collected by Johns Hopkins University of Medicine.

The UK’s official number of new positive cases shot up by nearly a thousand on Friday to 4,322, the highest since May 8, after a separate ONS model pointed to about 6,000 new cases a day in England in the week to Sept. 10.

That was up from modelling of 3,200 cases per day in the previous week, with the North West and London seen as hotspots.

Health Minister Matt Hancock called a second national lockdown a last resort earlier on Friday and when he was asked about it said: “I can’t give you that answer now.”

SPREADING WIDELY ACROSS ALL AGES

The UK said its reproduction “R” number of infections has risen to a range of 1.1-1.4 from last week’s 1.0-1.2.

“We’re seeing clear signs this virus is now spreading widely across all age groups and I am particularly worried by the increase in rates of admission to hospital and intensive care among older people,” said Yvonne Doyle, Medical Director at Public Health England.

“This could be a warning of far worse things to come.”

Britain imposed new COVID regulations on the North West, Midlands and West Yorkshire from Tuesday. More than 10 million people in the United Kingdom are already in local lockdown, and restrictions for millions more could be on the way.

London Mayor Sadiq Khan said later on Friday that it was “increasingly likely” that additional measures would soon be required in Britain’s biggest city. He said he had seen evidence about the spread of the virus in London which was “extremely” concerning.

COVID-19 cases started to rise again in Britain in September, with between 3,000 and 4,000 positive tests recorded daily in the last week. This is still some way behind France, which is seeing more than 10,000 new cases a day.

“COVID-19 infection rates have increased in most regions, particularly the North West and London,” the ONS said.

The ONS said there had been clear evidence of an increase in the number of people testing positive aged 2 to 11 years, 17 to 24 years and 25 to 34 years.

Johnson was criticized by opposition politicians for his initial response to the outbreak and the government has struggled to ensure sufficient testing in recent weeks.

Asked by LBC radio why the testing system was such a “shambles”, Hancock said Dido Harding, who is in charge of the system, had done an “an extraordinary job.”

(Reporting by Guy Faulconbridge, Kate Holton and Sarah Young; Editing by Raissa Kasolowsky, Mike Collett-White, Philippa Fletcher, William Maclean)

Fed officials tussle over practical meaning of new inflation policy

By Howard Schneider and Ann Saphir

WASHINGTON (Reuters) – Federal Reserve policymakers on Friday began fleshing out what their new tolerance for inflation will mean in practice, an issue critical to how investors and households reshape their own outlooks even if it may not be relevant to any immediate decisions by the U.S. central bank.

The new policy, laid out in a strategic document last month and incorporated into a policy statement issued on Wednesday, pledges to keep interest rates near zero until inflation has hit the Fed’s 2% target and is on track “to moderately exceed” it “for some time.”

As it stands, with the coronavirus pandemic sapping demand, leaving millions of Americans unemployed, and threatening the survival of entire industries, inflation is not seen as the core risk. Economic projections released by the Fed this week show inflation only reaching 2% by the end of 2023, with any shift towards tighter monetary policy likely years down the road.

But how the Fed’s new language is interpreted by the central bank’s five current Washington-based governors and 12 regional bank presidents will be central to whether bond markets, stock investors and even consumers see the new approach as likely to be effective, and start behaving in a way that actually helps push inflation higher.

After years of weak inflation, that is the Fed’s hope. It is based on fears of a Japanese-style low inflation rut that can have its own damaging effects over time, and Fed officials on Friday started to outline their views of how to proceed.

Atlanta Fed President Raphael Bostic said, for example, that he’d be paying closer attention to how fast inflation rises rather than to its quarter-to-quarter level in implementing the new approach.

In an interview on Bloomberg Television, Bostic said if inflation went up to 2.3% but appeared stable “that would be fine … By contrast if we were at 2.2 and the next quarter at 2.4 and then at 2.6, that trajectory would give me concern” and perhaps require efforts to cool the economy.

‘GHOST STORIES’

Minneapolis Fed President Neel Kashkari, in contrast, laid out a more open-ended view in written comments describing why he dissented against the rate-setting Federal Open Market Committee’s policy statement on Wednesday.

The Fed, he felt, was setting itself up to make the same mistake it has in the past of reacting too quickly to inflation “ghost stories” and risked nipping off job growth too soon.

He said the Fed instead should switch its focus to core inflation, a slower moving variable that excludes volatile commodity prices, and ensure that it reached 2% on a “sustained basis.”

“I would have preferred the Committee make a stronger commitment to not raising rates until we were certain to have achieved our dual mandate objectives,” of maximum employment consistent with stable prices, Kashkari said in an essay.

A second dissent from Dallas Fed President Robert Kaplan argued the central bank should keep its options open to raise rates sooner if needed – a sign of the broad debate now taking place over just what the new framework will mean in practice.

Critics say they feel the Fed’s new approach rings hollow without strong measures to back it up and produce the higher inflation they seek, such as more aggressive bond-buying.

But St. Louis Fed President James Bullard said inflation may move higher on its own if, as he suspects, the economic recovery gains traction at a time when global supply chains are being reorganized, monetary policy is loose, and governments are issuing record levels of debt to finance pandemic-related spending.

“A lot of people on Wall Street are saying ‘you could not hit 2%, how are you going to have inflation above 2%?,'” Bullard said in webcast remarks to a Washington University in St. Louis forum.

“I think we are at a moment where you may see some inflation … You have got more relaxed central banks … You have got huge fiscal deficits which historically have been a catalyst for inflation. And you have possibly bottleneck-type pressures.”

(Reporting by Howard Schneider and Ann Saphir; Editing by Paul Simao)

T cell shortage linked to severe COVID-19 in elderly; antiseptic spray may limit virus spread

By Nancy Lapid

(Reuters) – The following is a roundup of some of the latest scientific studies on the novel coronavirus and efforts to find treatments and vaccines for COVID-19, the illness caused by the virus.

Shortage of ‘naive’ T cells raises COVID-19 risk in elderly

A lower supply of a certain type of immune cell in older people that is critical to fighting foreign invaders may help explain their vulnerability to severe COVID-19, scientists say. When germs enter the body, the initial “innate” immune response generates inflammation not specifically targeted at the bacteria or virus.

Within days, the more precise “adaptive” immune response starts generating antibodies against the invader along with T cells that either assist in antibody production or seek out and attack infected cells.

In a small study published on Wednesday in Cell, COVID-19 patients with milder disease had better adaptive immune responses, and in particular, stronger T-cell responses to the coronavirus.

People over age 65 were much more likely to have poor T cell responses, and a poorly coordinated immune response in general, coauthor Shane Crotty of the La Jolla Institute for Immunology said in a news release.

As we age, our supply of “naive” T cells shrinks, he explained. Put another way, we have fewer “inexperienced” T cells available to be activated to respond to a new invader. “Ageing and scarcity of naive T cells may be linked risk factors for failure to generate a coordinated adaptive immune response, resulting in increased susceptibility to severe COVID-19,” the researchers said.

Antiseptic nasal spray may help limit coronavirus spread

An antiseptic nasal spray containing povidone-iodine may help curb transmission of the new coronavirus, preliminary research suggests.

In test tube experiments, a team of ear, nose and throat doctors found that a povidone-iodine nasal spray inactivated the virus in as little as 15 seconds. The nasal spray they tested is typically used to disinfect the inside of the nose before surgery. Formulations designed for use on skin are not safe in the nose, the researchers note.

They reported on Thursday in JAMA Otolaryngology – Head and Neck Surgery that they now have their patients use the spray before intranasal procedures, to reduce the risk of virus transmission through the air via droplets and aerosol spread.

They also suggest instructing patients to perform nasal decontamination before coming to appointments, to “further decrease intranasal viral load and … prevent spread in waiting areas and other common areas.” They caution, however, that routine use of povidone-iodine would not be safe for some people, including pregnant women and patients with thyroid conditions. Larger clinical trials have not yet proved that viral transmission is curbed by intranasal povidone-iodine solutions, but “these studies are already underway,” the researchers said.

Not all COVID-19 antibody tests are equal

Some COVID-19 antibody tests are much more reliable than others. But even with the best ones, reliability varies among patient subgroups, a new study suggests. Some tests look for IgM or IgA antibodies, the first antibodies produced by the immune system in response to an invader, which do not remain long in the body.

Other tests – the most common kind – look for IgG antibodies, which generally develop within seven to 10 days after symptoms begin and remain in the blood for some time after the patient recovers.

In a study posted on medRxiv on Wednesday in advance of peer review, researchers analyzed data from 11,809 individuals whose COVID-19 had been diagnosed with highly rated tests to see how well the various antibody assays would “recall” that the patient had been infected.

The most commonly used assays, which look for IgG, had a 91.2% recall rate. But the IgA and IgM assays had estimated recall rates of 20.6% and 27.3%, respectively, coauthor Natalie Sheils of UnitedHealth Group told Reuters. “Recall varies significantly across sub-populations and according to timing of the tests, with performance becoming relatively stable after day 14,” she said. “The tests performed better for men versus women, for non-whites versus whites and for individuals above age 45.” More research is needed to understand why these variations occur, Sheils added.

(Reporting by Nancy Lapid; Editing by Bill Berkrot)