Tag Archives: COVID-19

German COVID-19 cases are growing exponentially again: RKI

BERLIN (Reuters) – Coronavirus infections are rising exponentially in Germany, an expert at the Robert Koch Institute for infectious diseases said on Tuesday, putting at risk plans to lift the lockdown and revive the economy.

The number of cases per 100,000 reported on Tuesday was 83.7, up from 68 a week ago, and the RKI has said that metric could reach 200 by the middle of next month.

Germany is definitely in a third wave of the pandemic, driven by the fact it has loosened restrictions in recent weeks just as a more transmissible variant has spread, Dirk Brockmann, an epidemiologist at the RKI, told Germany’s ARD television.

“It has been totally irrational to loosen up here. It is just fueling this exponential growth,” he said.

Chancellor Angela Merkel and state leaders agreed a phased easing of curbs earlier this month along with an “emergency brake” to let authorities reimpose restrictions if case numbers rise above 100 per 100,000 on three consecutive days.

They are due to meet again on March 22 to discuss whether to allow any further relaxation of the rules.

The state government in the city of Berlin decided on Tuesday to put on hold any more easing, such as allowing restaurants or cinemas to open, the Tagesspiegel newspaper reported.

VACCINATION WOES

Germany’s decision on Monday to suspend AstraZeneca’s vaccine could delay progress in reaching herd immunity and postpone an economic recovery in the second quarter, analysts said.

The decision follows seven cases of thrombosis in Germany, including three deaths, and delivers a major setback to the country’s drive to speed up its sluggish vaccination campaign.

A planned meeting between Merkel and state leaders on Wednesday to discuss using family doctors to administer COVID-19 vaccines has been postponed until after the European Medicines Agency completes its review into the AstraZeneca shot.

AstraZeneca has said an analysis of its safety data covering reported cases from over 17 million vaccine doses given had shown no evidence of an increased risk of pulmonary embolism, deep vein thrombosis or low levels of platelets.

The RKI’s Brockmann noted that 1,000 people in a million had died of COVID-19, compared to possibly 1 in a million from complications associated with the vaccine.

“In the risk groups, the risk of dying of COVID is much, much higher. That means it is probably 100,000 times more likely to die of COVID than because of an AstraZeneca vaccine,” he said.

(Reporting by Emma Thomasson and Caroline Copley, Editing by Timothy Heritage and Gareth Jones)

Exclusive: Regular booster vaccines are the future in battle with COVID-19 virus, top genome expert says

By Guy Faulconbridge

CAMBRIDGE, England (Reuters) – Regular booster vaccines against the novel coronavirus will be needed because of mutations that make it more transmissible and better able to evade human immunity, the head of Britain’s effort to sequence the virus’s genomes told Reuters.

The novel coronavirus, which has killed 2.65 million people globally since it emerged in China in late 2019, mutates around once every two weeks, slower than influenza or HIV, but enough to require tweaks to vaccines.

Sharon Peacock, who heads COVID-19 Genomics UK (COG-UK) which has sequenced nearly half of all the novel coronavirus genomes so far mapped globally, said international cooperation was needed in the “cat and mouse” battle with the virus.

“We have to appreciate that we were always going to have to have booster doses; immunity to coronavirus doesn’t last forever,” Peacock told Reuters at the non-profit Wellcome Sanger Institute’s 55-acre campus outside Cambridge.

“We already are tweaking the vaccines to deal with what the virus is doing in terms of evolution – so there are variants arising that have a combination of increased transmissibility and an ability to partially evade our immune response,” she said.

Peacock said she was confident regular booster shots – such as for influenza – would be needed to deal with future variants but that the speed of vaccine innovation meant those shots could be developed at pace and rolled out to the population.

COG-UK was set up by Peacock, a professor at Cambridge, exactly a year ago with the help of the British’s government’s chief scientific adviser, Patrick Vallance, as the virus spread across the globe to Britain.

The consortium of public health and academic institutions is now the world’s deepest pool of knowledge about the virus’s genetics: At sites across Britain, it has sequenced 349,205 genomes of the virus out of a global effort of around 778,000 genomes.

On the intellectual frontline at the Wellcome Sanger Institute, hundreds of scientists – many with PhDs, many working on a voluntary basis and some listening to heavy metal or electronic beats – work seven days a week to map the virus’s growing family tree for patterns of concern.

Wellcome Sanger Institute has sequenced over half of the UK total sequenced genomes of the virus after processing 19 million samples from PCR tests in a year. COG-UK is sequencing around 30,000 genomes per week – more than the UK used to do in a year.

MUTATION LEADERBOARD

Three main coronavirus variants – which were first identified in Britain (known as B.1.1.7), Brazil (known as P1) and South Africa (known as B.1.351) – are under particular scrutiny.

Peacock said she was most worried about B.1.351.

“It is more transmissible, but it also has a change in a gene mutation, which we refer to as E484K, which is associated with reduced immunity – so our immunity is reduced against that virus,” Peacock said.

With 120 million cases of COVID-19 around the world, it is getting hard to keep track of all the alphabet soup of variants, so Peacock’s teams are thinking in terms of “constellations of mutations”.

“So a constellation of mutations would be like a leaderboard if you like – which mutations in the genome that we’re particularly concerned about, the E484K is must be one of the top of the leaderboard,” she said.

“So we’re developing our thinking around that leaderboard to think, regardless of the background and lineage, about what mutations or constellation of mutations are going to be important biologically and different combinations that may have slightly different biological effects.”

Peacock, though, warned of humility in the face of a virus that has brought so much death and economic destruction.

“One of the things that the virus has taught me is that I can be wrong quite regularly – I have to be quite humble in the face of a virus that we know very little about still,” she said.

“There may be a variant out there that we haven’t even discovered yet.”

There will, though, be future pandemics.

“I think its inevitable that we will have another virus emerge that is of concern. What I hope is that having learned what we have in this global pandemic, that we will be better prepared to detect it and contain it.”

(Reporting by Guy Faulconbridge; Editing by Kate Holton and Philippa Fletcher)

Germany, Italy, France to halt AstraZeneca shots, further hitting EU vaccination campaign

By Thomas Escritt and Stephanie Nebehay

BERLIN/GENEVA (Reuters) – Germany, France and Italy said on Monday they would stop administering the AstraZeneca COVID-19 vaccine after several countries reported possible serious side-effects, throwing Europe’s already struggling vaccination campaign into disarray.

Denmark and Norway stopped giving the shot last week after reporting isolated cases of bleeding, blood clots and a low platelet count. Iceland and Bulgaria followed suit and Ireland and the Netherlands announced suspensions on Sunday.

The moves by some of Europe’s largest and most populous countries will deepen concerns about the slow rollout of vaccines in the region, which has been plagued by shortages due to problems producing vaccines, including AstraZeneca’s.

Germany warned last week it was facing a third wave of infections, Italy is intensifying lockdowns and hospitals in the Paris region are close to being overloaded.

German Health Minister Jens Spahn said that although the risk of blood clots was low, it could not be ruled out.

“This is a professional decision, not a political one,” Spahn said adding he was following a recommendation of the Paul Ehrlich Institute, Germany’s vaccine regulator.

France said it was suspending the vaccine’s use pending an assessment by the EU medicine regulator due on Tuesday. Italy said its halt was a “precautionary and temporary measure” pending the regulator’s ruling.

Austria and Spain have stopped using particular batches and prosecutors in the northern Italian region of Piedmont earlier seized 393,600 doses following the death of a man hours after he was vaccinated. It was the second region to do so after Sicily, where two people had died shortly after having their shots.

The World Health Organization appealed to countries not to suspend vaccinations against a disease that has caused more than 2.7 million deaths worldwide.

“As of today, there is no evidence that the incidents are caused by the vaccine and it is important that vaccination campaigns continue so that we can save lives and stem severe disease from the virus,” WHO spokesman Christian Lindmeier said.

The United Kingdom said it had no concerns, while Poland said it thought the benefits outweighed any risks.

“UNUSUAL” SYMPTOMS

AstraZeneca’s shot was among the first and cheapest to be developed and launched at volume since the coronavirus was first identified in central China at the end of 2019 and is set to be the mainstay of vaccination programs in much of the developing world.

Thailand announced plans on Monday to go ahead with the Anglo-Swedish firm’s shot after suspending its use on Friday but Indonesia said it would wait for the WHO to report.

The WHO said its advisory panel was reviewing reports related to the shot and would release its findings as soon as possible. But it said it was unlikely to change its recommendations, issued last month, for widespread use, including in countries where the South African variant of the virus may reduce its efficacy.

The European Medicines Agency (EMA) has also said there was no indication the events were caused by the vaccination and that the number of reported blood clots was no higher than seen in the general population.

The handful of reported side-effects in Europe have upset vaccination programs already under pressure over slow rollouts and vaccine skepticism in some countries.

The Netherlands said on Monday it had seen 10 cases of possible noteworthy adverse side-effects from the AstraZeneca vaccine, hours after the government put its vaccination program on hold following reports of potential side-effects in other countries.

Denmark reported “highly unusual” symptoms in a 60-year-old citizen who died from a blood clot after receiving the vaccine, the same phrase used on Saturday by Norway about three people under the age of 50 it said were being treated in hospital.

“It was an unusual course of illness around the death that made the Danish Medicines Agency react,” the agency said in a statement late on Sunday.

One of the three health workers hospitalized in Norway after receiving the AstraZeneca shot had died, health authorities said on Monday, but there was no evidence that the vaccine was the cause. They said they would continue their probe and that no more suspected cases had been reported since Saturday.

AstraZeneca said earlier it had conducted a review covering more than 17 million people vaccinated in the European Union and the UK which had shown no evidence of an increased risk of blood clots.

Investigations into potential side-effects are complicated as the history of each case and circumstances surrounding a death or illness are examined. Austrian authorities have said their review of the AstraZeneca batch will take about two weeks.

The EMA has said that as of March 10, a total of 30 cases of blood clotting had been reported among close to 5 million people vaccinated with the AstraZeneca shot in the European Economic Area, which links 30 European countries.

The WHO said that as of March 12, more than 300 million doses of COVID-19 vaccines had been administered around the world with no deaths found to have been caused by any of them.

(Reporting by Panarat Thepgumpanat in BANKOK and Andreas Rinke and Paul Carrel in BERLIN, Angelo Amante in ROME, Christian Lowe in PARIS, Toby Sterling in AMSTERDAM, Jacob Gronholt-Pedersen in COPENHAGEN and Stanley Widianto in JAKARTA; writing by Philippa Fletcher; editing by Nick Macfie)

COVID-19 situation in Paris area extremely tense: French PM

PARIS (Reuters) – The COVID-19 situation in the Paris region is extremely tense and authorities are ready to take new measures, French Prime Minister Jean Castex said on Friday, but he did not announce a tightening of curfew or new regional lockdowns.

Despite rising COVID-19 cases, the administration of President Emmanuel Macron has not to date declared a new national lockdown, opting instead to tighten measures locally in hard-hit towns like Nice and Dunkirk, but Paris has been spared so far.

“I call on everyone, and especially those who live in the capital, to be extremely careful, wear the mask and respect social distancing. The aim is to reduce the pressure on the hospital system,” Castex said during a visit to a hospital.

The number of people with COVID-19 in intensive care units on Friday exceeded 4,000 for the first time since Nov. 26, with nearly 1,100 COVID-19 patients in ICUs in the Paris region alone.

In Paris and the surrounding region, healthcare managers say the intensive care units are close to being overloaded.

Castex said that in the Ile-de-France region around Paris the vaccination campaign would be sped up this weekend, with the delivery of 25,000 extra doses.

France’s vaccination program has been hampered by logistical bottlenecks and problems with deliveries from vaccine manufacturers but Castex said the campaign was speeding up, with 320,326 shots administered on Friday, a new record.

As of Friday, 7.04 million people – more than one tenth of the French population — had been vaccinated, official figures showed, including 2.22 million second injections.

(Reporting by GV De Clercq; editing by Jonathan Oatis, Kirsten Donovan)

U.S., India, Japan and Australia agree to provide a billion vaccine doses in Asia

By David Brunnstrom, Michael Martina and Jeff Mason

WASHINGTON (Reuters) – U.S. President Joe Biden and the leaders of Australia, India and Japan agreed in a summit on Friday to cooperate in providing up to a billion coronavirus vaccine doses to developing countries in the Indo-Pacific by the end of 2022, a move to counter China’s widening vaccine diplomacy.

Biden, hosting the first leader-level meeting of a group central to his efforts to counter China’s growing military and economic power, said a free and open Indo-Pacific region was “essential” to all four countries.

“The United States is committed to working with you, our partners, and all our allies in the region, to achieve stability,” he said.

Biden’s national security adviser, Jake Sullivan, said the leaders addressed key regional issues at the virtual meeting, “including freedom of navigation and freedom from coercion” in the South and East China Sea, the North Korean nuclear issue, and the coup and violent repression in Myanmar.

Sullivan told a news briefing the meeting discussed the challenges posed by China, although this was not the focus. He said that among the issues discussed were recent cyberattacks and semi-conductor supply-chain issues.

The Quad leaders committed to delivering up to one billion doses of COVID-19 vaccines to Southeast Asia by the end of 2022, Sullivan said .

Japanese Prime Minister Yoshihide Suga said he wanted the four “to forge strongly ahead toward the realization of a free and open Indo-Pacific” and that Japan had agreed to cooperate in providing vaccine-related support to developing countries.

He also told reporters he had expressed strong opposition to attempts by China to change the status quo in the region and that the four leaders had agreed to cooperate on the issue.

India and Australia also emphasized the importance of regional security cooperation, which has been enhanced by previous lower-level Quad meetings.

India Foreign Secretary Harsh Vardhan Shringla said the meeting had agreed U.S. vaccines would be manufactured in India, something New Delhi has called for to counter Beijing’s widening vaccine diplomacy.

In a joint statement the leaders pledged to work closely on COVID-19 vaccine distribution, climate issues and security.

“We strive for a region that is free, open, inclusive, healthy, anchored by democratic  values, and unconstrained by coercion,” they added, without mentioning China by name.

The meeting also agreed to set up a group of experts to help distribute vaccines, as well as working groups for cooperation on climate change, technology standards, and joint development of emerging technologies.

The leaders agreed to hold an in-person meeting later this year.

India, Australia and Japan have all faced security challenges from China, strengthening their interest in the Quad. Quad cooperation dates back to their joint response to the Indian Ocean earthquake and tsunami in 2004.

The Quad was revived under the Trump administration, which saw it as a vehicle to push back against China. The United States hosted a foreign ministers’ meeting in 2019, which was followed by another in Japan last year and a virtual session in February.

Friday’s meeting coincided with a major U.S. diplomatic drive to solidify alliances in Asia and Europe to counter China, including visits next week by Secretary of State Antony Blinken and Defense Secretary Lloyd Austin to Japan and South Korea.

Blinken will also meet in Alaska with China’s top diplomat, Yang Jiechi, and State Councillor Wang Yi – the first high-level in-person contact between the world’s two largest economies under the Biden administration.

Washington has said it will not hold back in its criticism of Beijing over issues ranging from Taiwan to Hong Kong and the genocide it says China is committing against minority Muslims.

Modi told the session the Quad had “come of age” and would “now remain an important pillar of stability in the region.” Australian Prime Minister Scott Morrison called the meeting “a whole new level of cooperation to create a new anchor for peace and stability in the Indo-Pacific.”

A fact sheet issued after the meeting said the United States, through its International Development Finance Corp, would work to finance Indian drugmaker Biological E Ltd to produce at least 1 billion COVID-19 vaccine doses by end of 2022.

It also said Japan was in discussions to provide concessional yen loans for India to expand manufacturing of COVID-19 vaccines for export.

The Biden administration told Reuters on Tuesday the United States and Japan would help fund Indian firms manufacturing vaccines for U.S. drugmakers Novavax Inc and J&J.

However, Indian government sources say U.S. curbs on exports of critical materials could hamper that effort and those to start large-scale distribution to Southeast Asia.

(Reporting by David Brunnstrom, Michael Martina, Jeff Mason and Doina Chiacu; additonal reporting by Kiyoshi Takenaka in Tokyo; Editing by Gareth Jones and Alistair Bell)

WHO tries to quash nervousness about AstraZeneca vaccine

By Emma Farge and Emilio Parodi

GENEVA/MILAN/SOFIA (Reuters) – The World Health Organization squarely endorsed AstraZeneca’s coronavirus vaccine on Friday, as Thailand joined a number of smaller European countries in suspending use of the shot because of sporadic reports of blood clots among recipients.

Bulgaria also joined Denmark, Norway and Iceland, which all stopped using the vaccine on Thursday. Austria, Italy, Luxembourg, Estonia, Lithuania and Latvia stopped using certain batches.

“Until all doubts are dispelled…, we are halting inoculations with this vaccine,” Bulgarian Prime Minister Boyko Borissov said.

His health minister, Kostadin Angelov, said a 57-year-old woman had died of heart failure 15 hours after receiving an AstraZeneca shot, but urged those already inoculated to stay calm.

“We do not have any official data that proves a causal connection,” he said.

That line was reinforced by the WHO, which is keenly aware that AstraZeneca’s shot is by far the cheapest and most high-volume launched so far, and set to be the mainstay of vaccination programs in much of the developing world.

Spokeswoman Margaret Harris said the vaccine was “excellent”.

“It’s very important to understand that, yes, we should continue to be using the AstraZeneca vaccine,” she told a briefing. “All that we look at is what we always look at: Any safety signal must be investigated.”

The EU regulator, the European Medicines Agency (EMA), said on Wednesday that there had been 22 reports of embolisms from blood clots among 3 million people who had received the vaccine – no more than in the general population – but Bulgaria said it wanted to see that guidance in written form.

‘THIS NEEDS TO BE EXPLAINED’

Experts point to the difficulty of putting risks in perspective for a wider public that may be spooked by negative headlines.

In Sicily, where two people died shortly after being vaccinated, the regional health administrator said 7,000 inoculation appointments had been cancelled as a result.

Silvestro Scotti, a family doctor in Naples and head of the Italian Federation of General Practitioners, said he had been bombarded all day with inquiries from people nervous about getting the AstraZeneca shot.

“The crazy thing is that, even if the correlation between the vaccine and blood clots were proved, it would be a rate of 0.007 out of a thousand,” he said.

“To give an example: the birth control pill, which is used widely and doesn’t worry anyone, has a proven risk rate of 0.6 in a thousand. Even in the worst-case scenario, the risk/benefit ratio for this vaccine is extraordinarily favorable. That needs to be explained to people.”

The WHO’s Harris said 268 million doses of COVID-19 vaccines from various developers had been administered worldwide without being shown to have caused a single death.

In France, where distrust of vaccination is long-established, only 43% said they trusted the AstraZeneca shot in a Harris Interactive poll conducted on March 11-12, while 55% said they trusted COVID-19 vaccines in general.

Germany has also had to contend with substantial skepticism, to the extent that Health Minister Jens Spahn suggested that the AstraZeneca shot be given to the police force and army, after some health and other frontline workers baulked at receiving it.

However, German authorities’ main concern has been lack of supply, rather than lack of acceptance, as social and economic restrictions to limit transmission take their toll.

One doctor administering vaccinations in Berlin said recipients were now asking far fewer questions about the vaccine than two weeks ago.

(Additional reporting by Stephanie Nebehay in Geneva, Crispian Balmer in Rome, Paul Carrel in Berlin, Tsvetelia Tsolova in Sofia, Matthias Blamont in Paris; Writing by Kevin Liffey; Editing by Mark Heinrich)

Italy to impose nationwide coronavirus lockdown over Easter weekend – draft decree

By Angelo Amante

ROME (Reuters) – Italy will be placed under a nationwide lockdown over the Easter weekend for the second year running, a draft decree law seen by Reuters said on Friday, underlining the struggle to stem a fresh surge in coronavirus cases.

Non-essential shops will be shuttered nationwide from April 3-5. On those days, Italians will only be allowed to leave their homes for work, health or emergency reasons.

However, a number of regions including wealthy Lombardy, which is centered on Italy’s financial capital Milan, look certain to be placed under full lockdown from Monday because of the recent jump in infections and hospitalizations.

“I hope that this will be the last sacrifice asked of our citizens,” said Lombardy President Attilio Fontana.

Italy, the first Western country hit hard by the pandemic, saw infections rise by 10% this week compared with the week before, and officials have warned that the situation is deteriorating as new, highly contagious variants gain ground.

The country was placed under its first nationwide lockdown a year ago, which lasted 10 weeks. A second lockdown was imposed at Christmas. In recent months, the government has introduced restrictions at a regional level, depending on case numbers.

It was not immediately clear how the decree would affect churchgoers in the Catholic country. However, it was expected to be similar to provisions last Christmas when people were allowed to go to churches in their neighborhoods.

A Vatican source said Pope Francis’ Easter Eve Mass likely would be held a few hours earlier so that faithful could get home in time for Italy’s 10 p.m. curfew and that the pontiff’s Holy Week activities before Easter would be held in the Vatican with a limited number of participants.

Unlike last year, the new decree, which was expected to be approved by Prime Minister Mario Draghi’s cabinet later on Friday, allows for limited visits to friends and relatives over the Easter holiday – for example to see elderly parents.

But the decree also imposes tougher curbs for the country’s low-risk “yellow” regions as of Monday, severely limiting movement between towns and closing restaurants and bars.

“The spread of the virus is accelerating due to the impact of variants. We agree with the government’s choices,” Stefano Bonaccini, president of Italy’s conference of regions, said in a statement after meeting ministers.

Alongside some nationwide measures, Italy calibrates restrictions in its 20 regions according to a four-tier, color-coded system (white, yellow, orange and red) based on infection levels and revised every week.

Italy has reported more than 100,000 deaths from the disease since discovering its first cases 13 months ago, the seventh highest toll worldwide.

(Reporting by Angelo Amante; Editing by Crispian Balmer/Mark Heinrich)

Brazil hospitals pushed to limit as COVID-19 death toll soars

By Eduardo Simões and Rodrigo Viga Gaier

SAO PAULO (Reuters) – Hospitals in Brazil’s main cities are reaching capacity, health officials warned, as the country recorded the world’s highest COVID-19 death toll over the past week, triggering tighter restrictions on Thursday in its most populous state.

Intensive care wards for treating COVID-19 patients have reached critical occupancy levels over 90% in 15 of 27 state capitals, according to biomedical center Fiocruz.

Porto Alegre in southern Brazil has no free intensive care units (ICUs) and occupancy hit 100% in two other state capitals, Fiocruz reported.

The Health Ministry on Wednesday reported a record 2,286 deaths from COVID-19 in the last 24 hours, as new infections rose by 79,876.

With more than 270,000 deaths, Brazil’s pandemic death toll over the past year trails only the United States. But over the past week, Brazil has averaged more than 1,600 deaths per day, ahead of some 1,400 in the United States, where the outbreak has ebbed.

As President Jair Bolsonaro rails against lockdowns and urges Brazilians out of their homes, governors and mayors have struggled to enforce restrictions, often pleading in vain with a population inured to the rising tide of the epidemic.

The far-right president attacked governors for the lockdowns again on Thursday, including Sao Paulo state’s move to ban soccer matches. He said they were increasing poverty with a medicine that was worse than the virus.

“How long can we stand this lockdown irresponsibility? You close everything and you destroy millions of jobs. Lockdown is not a cure,” Bolsonaro said in a remote talk to a business group with Economy Minister Paulo Guedes at his side.

Brazil’s two most populous cities, Sao Paulo and Rio de Janeiro, on Thursday moved to tighten measures as their hospitals struggled with a second wave of the virus, driven by a more contagious variant that emerged in the Amazon region.

While Europe and the United States ramp up vaccinations and bring down their caseloads, Brazil’s federal government is off to a slow start, with only 2% of the 210 million Brazilians fully inoculated so far.

In the nation’s capital Brasilia, which is under a nighttime curfew, public hospital ICU wards are 97% full and private ones are at 99%, forcing the city to again set up field hospitals as it had during a peak in cases last year.

On Thursday, Sao Paulo Governor João Doria announced a “new stage” of restrictions to enforce social distancing, arguing it is now the only weapon against the spread of the virus.

They include a curfew from 8:00 p.m. to 5:00 a.m., the suspension of religious services and sports events, including soccer matches, and people not being allowed to use beaches and parks.

“This is a tough, unpopular decision. No governor wants to stop the economic activities in their state,” Doria said at a news conference.

The state of Sao Paulo, home to some 44 million people, is currently allowing only essential stores such as supermarkets and pharmacies to receive shoppers.

The Sao Paulo health secretary said hospitals in more than half of the state’s municipalities are full and half the patients are under 50 years old.

Last year, the most serious cases were concentrated among elderly Brazilians.

(Reporting by Eduardo Simoes in Sao Paulo and Rodrigo Viga Gaier in Rio de Janeiro; Writing by Jamie McGeever and Anthony Boadle; Editing by Brad Haynes, Bill Berkrot and Jonathan Oatis)

COVID variant ‘taking over’ UK and likely to dominate elsewhere: expert

By Kate Kelland

LONDON (Reuters) – A coronavirus variant first found a few months ago in Britain is now “taking over” and causing 98% of all cases in the UK, the scientist leading the country’s variant-tracking research said on Thursday.

Sharon Peacock said the UK variant, known as B.1.1.7, also appears to be gaining a firm grip in many of the 100 or so other countries it has spread to in the past few months.

“It’s around 50% more transmissible – hence its success in really taking over the country,” said Peacock, director of the COVID-19 Genomics UK (COG-UK) consortium of scientists monitoring mutations in the coronavirus.

“We now know that it has spread across the UK and causes nearly all of the cases of COVID-19 – about 98%,” she told an online briefing for Britain’s Royal Society of Medicine.

“It appears to be the case that the other variants are not getting a foothold in this country.”

The B.1.1.7 variant, first detected in September 2020, has 23 mutations in its genetic code – a relatively high number of changes – and is thought by experts to be 40%-70% more transmissible than previously dominant variants.

Peacock also noted data released on Wednesday from a UK study which found that B.1.1.7 has “significantly higher” mortality, with death rates among those infected with it between 30% and 100% greater than among those infected with previous variants.

“There is a small increase in the likelihood of death from the variant,” she said.

The World Health Organization says B.1.1.7 is one of several “variants of concern,” along with others that have emerged in South Africa and Brazil. The variants are mutant versions of the SARS-CoV-2 virus that causes COVID-19, which has already killed more than 2.7 million people in the pandemic.

B.1.1.7 has spread to about 100 countries, according to WHO data, and some of those, including France, Denmark and the United States, have reported swift rises in the proportion of their COVID-19 cases being caused by it.

Peacock said evidence from the UK suggests B.1.1.7. is likely to become dominant elsewhere too.

“Because of its transmissibility, once it’s introduced, it does have that advantage over other circulating variants – so it is the case that B.1.1.7 appears to be travelling around the world and really expanding where it lands.”

Public Health England (PHE) also said on Thursday that a new coronavirus variant had been identified in the UK in two people who had recently been in Antigua. PHE said it shared some traits of other variants but was not classed as concerning for now.

(Reporting by Kate Kelland, Editing by William Maclean)

Army helicopter vaccine drop brings relief to tiny Irish island

By Clodagh Kilcoyne

ARRANMORE, Ireland (Reuters) – The army pilots landed their helicopter on the tiny Irish island of Arranmore just before lunch on Thursday and handed over their precious cargo of COVID-19 vaccines to Dr. Kevin Quinn and his grinning daughter Aoife.

The arrival of first batch of shots last month was a “joyous occasion,” Quinn said. Thursday’s delivery of second doses was even more momentous – he reckons he will now be able to fully vaccinate around half the population in the next few days.

With fewer than 500 residents, the remote island off the northwestern tip of Ireland is one of the hardest places to reach in a vaccination program that, like in the rest of the European Union, has been hampered by supply problems.

The two army pilots took one hour and 40 minutes to fly in from the Casement Aerodrome military air base on the outskirts of Dublin. Aoife, who works as a nurse on Arranmore, helped her father and the crew carry the frozen boxes of Moderna shots to his car, parked down a lane.

“We’re privileged to get the second doses so soon and grateful of the recognition of the unique need of isolated communities,” Quinn said after seeing the helicopter arrive.

“The mood was incredible after the first vaccine, a lovely joyous occasion and one of the best days I’ve had in general practice.”

Ireland has administered 536,000 vaccines among its population of 4.9 million to healthcare workers, care home residents and the most elderly. Just over 154,000 or 3% of the population have received the second of their two doses.

Army helicopters have also been deployed to drop vaccines to the Aran Islands off the west coast of Ireland.

Two Naval Ships docked in Dublin and Galway were used for temporary testing early in the pandemic, before officers ran a testing center at the national Aviva Stadium, with others redeployed to assist with contact tracing.

Personnel are now setting up and managing mass vaccination centers around the country and will soon be involved in the running of quarantine hotels.

For the people of Arranmore, half of whom are above the age of 60, some normality is at last on the horizon. The island is one of a small number of areas where the majority are fluent in native Irish and many use it as their working language.

“With an elderly population and a diaspora that mostly live in Dublin, Glasgow or America, it’s been extremely difficult,” said Quinn. “Hopefully this summer will be better than last.”

(Writing and additional reporting by Padraic Halpin; Editing by Andrew Heavens)