Tag Archives: vaccines

New coronavirus variant identified in New York: researchers

By Deena Beasley

(Reuters) – A new coronavirus variant that shares some similarities with a more transmissible and intractable variant discovered in South Africa is on the rise in New York City, researchers said on Wednesday.

The new variant, known as B.1.526, was first identified in samples collected in New York in November, and by mid-February represented about 12% of cases, researchers at Columbia University Vagelos College of Physicians and Surgeons, said on Wednesday.

The variant was also described in research originally published online February 15 by California Institute of Technology scientists. Neither study has been reviewed by outside experts.

The Columbia researchers said an analysis of publicly available databases did not show a high prevalence of coronavirus variants recently identified in South Africa and Brazil in case samples from New York City and surrounding areas.

“Instead we found high numbers of this home-grown lineage,” Dr. Anne-Catrin Uhlemann, assistant professor in the division of infectious diseases at Columbia University’s College of Physicians and Surgeons, said in a statement.

The Columbia study was designed to search genomes from patient samples for mutations associated with worrisome British, South African and Brazilian virus variants. One mutation, E484K, in a genome region encoding the virus receptor binding domain, has been shown to be an escape mutation that greatly reduces the effectiveness of monoclonal and vaccine-induced antibodies.

Of the 65 virus samples containing the E484K mutation Ho’s team identified, a handful represented cases involving the known concerning variants, but 49 of the 65 belonged to the new New York B.1.526 lineage.

Studies have shown that recently launched coronavirus vaccines are still likely to neutralize the virus and protect against severe illness, even for infections with new variants. Vaccine makers are also working to develop booster shots to combat mutated versions of the virus.

Philippines offers nurses in exchange for vaccines from Britain, Germany

By Neil Jerome Morales

MANILA (Reuters) – The Philippines will let thousands of its healthcare workers, mostly nurses, take up jobs in Britain and Germany if the two countries agree to donate much-needed coronavirus vaccines, a senior official said on Tuesday.

The Philippines, which has among Asia’s highest number of coronavirus cases, has relaxed a ban on deploying its healthcare workers overseas, but still limits the number of medical professionals leaving the country to 5,000 a year.

Alice Visperas, director of the labor ministry’s international affairs bureau, said the Philippines was open to lifting the cap in exchange for vaccines from Britain and Germany, which it would use to inoculate outbound workers and hundreds of thousands of Filipino repatriates.

Nurses are among the millions of Filipinos who work overseas, providing in excess of $30 billion a year in remittances vital to the country’s economy.

“We are considering the request to lift the deployment cap, subject to agreement,” Visperas told Reuters.

Britain is grappling with the world’s sixth-highest coronavirus death toll and one of the worst economic hits from the pandemic, while Germany has the 10th most infections globally.

While the two countries have inoculated a combined 23 million people, the Philippines has yet to start its campaign to immunize 70 million adults, or two-thirds of its 108 million people. It expects to receive its first batch of vaccines this week, donated by China.

The Philippines wants to secure 148 million doses of vaccines altogether.

The British embassy in Manila did not immediately respond to a request for comment while calls to Germany’s mission went unanswered.

In 2019, almost 17,000 Filipino nurses signed overseas work contracts, government data showed.

While Filipino nurses have fought to lift the deployment ban to escape poor working conditions and low pay at home, the workers-for-vaccine plan has not gone down well with some medical workers.

“We are disgusted on how nurses and healthcare workers are being treated by the government as commodities or export products,” Jocelyn Andamo, secretary general of the Filipino Nurses United, told Reuters.

India says virus variants not behind upsurge in cases

By Krishna N. Das and Neha Arora

NEW DELHI (Reuters) – India said on Tuesday mutated versions of coronavirus were not responsible for an upsurge in cases in two states, a potential relief for a country where mask-wearing and social distancing have largely disappeared.

Maharashtra in the west and Kerala in the south account for 75% of India’s current active cases of about 147,000, and both states have seen a sudden rise in new infections in recent days, fueling calls for a faster roll-out of vaccines.

India has reported more than 11 million cases – the most in the world after the United States – and about 156,000 deaths. Actual infections have inched closer to 300 million in the country of 1.35 billion, according to a random study of antibodies done by the government.

A top government health official confirmed the long-time presence of two mutants – N440K and E484Q – in those two states as well as elsewhere in the country and abroad. Authorities have also found the UK variant in 187 people in India, the South African one in six and one case of the Brazilian mutation.

“There is no reason today for us to believe, on the basis of scientific information, that these are responsible for the upsurge of the outbreak,” Vinod Kumar Paul, who heads a government committee on vaccines, told a news conference.

Though cases have come down sharply since a September peak, Paul said India was still vulnerable, especially given that even previously badly affected cities like Pune in Maharashtra were getting hit again. He urged people to wear masks and avoid social events – guidelines openly flouted by both federal and state ministers.

The northern state of Punjab, which has also seen a rise in cases, said indoor gatherings would be restricted to 100 and outdoor to 200 from March 1. District heads have also been permitted to decide on night curfews in hotspots, and testing will be increased, the state’s chief minister said.

Punjab is one of the worst performing states in vaccinating their healthcare workers, according to the federal government.

The government on Tuesday asked five states, including Maharashtra and Punjab, to expedite vaccination of their healthcare and frontline workers in light of the surge in cases, according to letters shared by the health ministry.

India has given nearly 12 million doses to its health and frontline workers since beginning the campaign in mid-January, a pace that will have to be increased sharply to meet the target of reaching 300 million people by August.

Health Secretary Rajesh Bhushan said India would very soon start immunizing people over 50 and those with medical conditions, with greater involvement from private hospitals. Government hospitals are now running around 80% of vaccination sites.

The government has recently come under pressure to expand coverage at home given the world’s largest vaccine maker has exported COVID-19 shots to more than two dozen countries.

India is using a vaccine developed by Bharat Biotech and the state-run Indian Council of Medical Research, and another licensed from AstraZeneca and Oxford University. Other vaccines are in the queue, including Russia’s Sputnik V and products from Cadila Healthcare and Novavax.

(Reporting by Krishna N. Das and Neha Arora; Editing by Gareth Jones, William Maclean, Philippa Fletcher and Giles Elgood)

A day that will live in infamy: U.S. crosses 500,000th COVID-19 death

By Maria Caspani and Anurag Maan

NEW YORK (Reuters) – The United States on Monday crossed the staggering milestone of 500,000 COVID-19 deaths just over a year to the day since the coronavirus pandemic claimed its first known U.S. victims in Santa Clara County, California.

The country had recorded more than 28 million COVID-19 cases and 500,054 lives lost as of Monday afternoon, according to a Reuters tally of public health data, although daily deaths and hospitalizations have fallen to the lowest level since before the Thanksgiving and Christmas holidays.

About 19% of total global coronavirus deaths have occurred in the United States, an outsized figure given that the nation accounts for just 4% of the world’s population.

“These numbers are stunning,” Dr. Anthony Fauci, a top infectious disease adviser to President Joe Biden told ABC News’ “Good Morning America” program. “If you look back historically, we’ve done worse than almost any other country and we’re a highly developed, rich country.”

Biden and Vice President Kamala Harris are set to commemorate the huge loss of life due to COVID-19 later on Monday during an event at the White House that will include a speech by the president, a moment of silence and a candle lighting ceremony.

Biden will also order that U.S. flags on federal property be lowered to half staff for five days, White House spokeswoman Jen Psaki told reporters.

The National Cathedral in Washington will also toll its bells 500 times on Monday evening to honor the lives lost to COVID-19 in a livestream event, according to a notice on its website.

In 2020, the virus has taken a full year off the average life expectancy in the United States, the biggest decline since World War Two.

Sweeping through the country at the beginning of last year, the U.S. epidemic had claimed its first 100,000 lives by May.

The death toll doubled by September as the virus ebbed and surged during the summer months.

Pandemic-weary Americans, like so many around the world, grappled with the mountain of loss brought by COVID-19 as health experts warned of yet another coronavirus resurgence during the upcoming fall and winter months.

Americans lost mothers and fathers, husbands and wives, brothers, sisters and friends to the virus. For many, the grief was amplified by the inability to see loved ones in hospitals or nursing homes and by the physical distancing imposed by authorities to curb the virus spread.

By December, the death toll had reached 300,000 as the United States entered a deadly post-holiday season that would claim 230,000 lives in the span of less than three months.

With numbers that made the appalling toll early in the pandemic pale by comparison, deaths recorded between December and February accounted for 46% of all U.S. COVID-19 fatalities, even as vaccines finally became available and a monumental effort to inoculate the American public got underway.

Despite the grim milestone, the virus appears to have loosened its grip as COVID-19 cases in United States fell for the sixth consecutive week. However, health experts have warned that coronavirus variants initially discovered in Britain, South Africa and Brazil could unleash another wave that threatens to reverse the recent positive trends.

Fauci cautioned against complacency and urged Americans to continue public health measures such as wearing masks, physical distancing and avoiding crowds while officials race to inoculate the population, particularly with these more contagious new variants circulating.

“We’ve got be really careful and not just say ‘OK we’re finished now, we’re through it,” he told ABC.

(Reporting by Maria Caspani in New York and Anurag Maan in Bengaluru and Susan Heavey in Washington; Writing by Maria Caspani; Editing by Bill Berkrot and Lisa Shumaker)

India virus infections at three-week high, Mumbai hires marshals to enforce mask-wearing

NEW DELHI (Reuters) – India reported on Friday its biggest jump in new coronavirus infections in three weeks, with 13,193 cases, while thousands of marshals fanned out to enforce mask wearing across the financial capital of Mumbai, which is battling a recent spurt.

The tally of confirmed infections is 10.96 million, the second highest after the United States, with more than 156,000 deaths. But actual infections could range as high as 300 million, a government serological survey showed this month.

In recent days, 75% of India’s new cases have been reported from the southern state of Kerala and Maharashtra, home to Mumbai, a densely populated city of 20 million people. The two states already had the highest number of reported infections.

Health experts suggest the re-opening of educational institutes in Kerala and resumption of suburban train services in Mumbai could be key factors.

After a gap of 11 months, Mumbai resumed on Feb. 1 full suburban train services, which before the pandemic carried a daily average of 8 million people.

The city has begun hiring marshals to enforce mask wearing. Out of nearly 5,000 marshals, around 300 would be deployed on the rail network, city authorities said.

Indians have largely given up on masks and social distancing, Reuters reporting shows.

“Coronavirus … has not yet left the country,” the health ministry said on Twitter. “We still need to follow COVID-appropriate behavior. No carelessness till there is a cure.”

Despite the recent rise in infections, India’s daily tally of new cases remains well below a mid-September peak of nearly 100,000. Testing numbers have also fallen to about 800,000 a day from more than 1 million.

Since starting its vaccine campaign in mid-January, India has administered nearly 10 million doses, aiming to cover 300 million people by August.

(Reporting by Krishna N. Das and Anuron Kumar Mitra; Editing by Simon Cameron-Moore)

65.9 million doses of COVID-19 vaccines delivered, 44.7 million administered: U.S. CDC

(Reuters) – The U.S. Centers for Disease Control and Prevention said it had administered 44,769,970 doses of COVID-19 vaccines in the country as of Wednesday morning and delivered 65,972,575 doses.

The tally of vaccine doses are for both Moderna and Pfizer/BioNTech, vaccines as of 6:00 a.m. ET on Wednesday, the agency said.

According to the tally posted on Tuesday, the agency had administered 43,206,190 doses of the vaccines, and delivered 62,898,775 doses.

The agency said 33,783,384 people had received 1 or more doses while 10,469,514 people have got the second dose as of Wednesday.

A total of 5,176,499 vaccine doses have been administered in long-term care facilities, the agency said.

(Reporting by Vishwadha Chander in Bengaluru; Editing by Ramakrishnan M.)

U.S. government to ship COVID-19 vaccines directly to community health centers starting next week

(Reuters) – The U.S. government will begin shipping COVID-19 vaccines directly to community health centers around the country next week in an effort to speed vaccination and ensure doses are reaching vulnerable populations, U.S. health officials said on Tuesday.

It will begin by shipping doses to 250 centers nationwide selected based on their proximity to vulnerable groups, such as homeless people and those with limited proficiency in English, they said, but will eventually scale to 1400 community health centers in the United States.

(Reporting by Carl O’Donnell; Editing by Chris Reese)

U.S. Senate passes budget plan to advance Biden’s $1.9 trillion COVID aid package

By Richard Cowan

WASHINGTON (Reuters) – President Joe Biden’s drive to enact a $1.9 trillion coronavirus aid bill gained momentum on Friday as the U.S. Senate narrowly approved a budget blueprint allowing Democrats to push the legislation through Congress in coming weeks with or without Republican support.

At the end of about 15 hours of debate and votes on dozens of amendments, the Senate found itself in a 50-50 partisan deadlock over passage of the budget plan. That deadlock was broken by Vice President Kamala Harris, whose “yes” vote provided the win for Democrats.

This was a “giant first step” toward passing the kind of comprehensive coronavirus aid bill that Biden has put at the top of his legislative agenda, Senate Majority Leader Chuck Schumer said.

Shortly before the final vote, Democrats flexed their muscles by offering an amendment reversing three earlier votes that Republicans had won.

Those had used the coronavirus aid battle to voice support for the Canada-to-United States Keystone XL pipeline that Biden has blocked and support for hydraulic fracking to extract underground oil and natural gas.

Also overturned was a Republican amendment barring coronavirus aid to immigrants living in the United States illegally.

With Democrat Harris presiding, she broke a 50-50 tie to overturn those Republican victories.

It marked the first time Harris, in her role as president of the Senate, cast a tie-breaking vote after being sworn in as Biden’s vice president on Jan. 20.

Before finishing its work, the Senate approved a series of amendments to the budget outline, which had already passed the House of Representatives on Wednesday. As a result, the House must now vote again to accept the Senate’s changes, which could occur as early as Friday.

For example, the Senate added a measure calling for increased funding for rural hospitals whose resources are strained by the pandemic.

Senate Democrats and the Biden administration have said they want comprehensive legislation to move quickly to address a pandemic that has killed more than 450,000 Americans and left millions jobless.

They want to spend the $1.9 trillion to speed COVID-19 vaccines throughout the nation. Other funds would extend special unemployment benefits that will expire at the end of March and make direct payments to people to help them pay bills and stimulate the economy.

They also want to send money to state and local governments dealing with the worst health crisis in decades.

But as the hours wore on and dozens of amendments were offered, exhausted senators mainly spent the night disposing of Republican ideas, such as ending all U.S. foreign aid and prohibiting Congress from expanding the U.S. Supreme Court beyond its current nine justices.

RANGE OF ISSUES

Senators voted on issues ranging from immigration and abortion to energy and taxes. But none of the approved amendments will carry the force of law in a budget blueprint and mainly are guidelines for developing the actual coronavirus aid bill in coming weeks.

More importantly, the budget plan unlocks a legislative tool called reconciliation that is designed to let Democrats approve Biden’s $1.9 trillion proposal by a simple majority.

Most legislation must get at least 60 votes in the 100-seat Senate to advance. But the chamber is divided 50-50 and Republicans oppose the Democratic president’s proposal. Reconciliation would allow the Senate’s 48 Democrats and two independents who align with them to approve the relief package, with a tie-breaking vote from Harris.

Republicans have countered the budget plan with proposals that would be less than one-third the cost. While their plan dovetails with the Democrats’ in some respects, Biden has deemed it as too anemic to put the country back on its feet after a year of suffering through the pandemic.

A group of 10 Republican senators who met with Biden at the White House on Monday sent him a letter on Thursday saying that significant amounts of money already appropriated by Congress have not yet been spent.

Last year, Congress passed emergency bills totaling around $4 trillion to deal with the health and economic crisis caused by the COVID-19 virus.

In early voting on Thursday, senators delivered a message to the Biden administration that direct payments should be tailored to those who need the money the most, as it voted 99-1 to recommend that high-income earners not qualify for a new round of government checks that could amount to $1,400 for individuals.

Senators did not specify income limits. But an earlier round of direct payments placed thresholds of $75,000 for individuals and $150,000 for married couples before the money would start scaling down.

“The decent compassionate thing is for us to target the relief to our neighbors who are struggling every day to get by” during the coronavirus pandemic, said Democratic Senator Joe Manchin, author of the proposal.

(Reporting by Richard Cowan; Editing by Angus MacSwan)

World faces around 4,000 COVID-19 variants as researchers explore mixed vaccine shots

By Guy Faulconbridge and Alistair Smout

LONDON (Reuters) – The world faces around 4,000 variants of the virus that causes COVID-19, prompting a race to improve vaccines, Britain said on Thursday, as researchers began to explore mixing doses of the Pfizer and AstraZeneca shots.

Thousands of variants have been documented as the virus mutates, including the so-called British, South African and Brazilian variants which appear to spread more swiftly than others.

British Vaccine Deployment Minister Nadhim Zahawi said it was very unlikely that the current vaccines would not work against the new variants.

“Its very unlikely that the current vaccine won’t be effective on the variants whether in Kent or other variants especially when it comes to severe illness and hospitalization,” Zahawi told Sky News.

“All manufacturers, Pfizer-BioNTech, Moderna, Oxford-AstraZeneca and others, are looking at how they can improve their vaccine to make sure that we are ready for any variant – there are about 4,000 variants around the world of COVID now.”

While thousands of variants have arisen as the virus mutates on replication, only a very small minority are likely to be important and to change the virus in an appreciable way, according to the British Medical Journal.

The so called British variant, known as VUI-202012/01, has mutations including a change in the spike protein that viruses use to bind to the human ACE2 receptor – meaning that it is probably easier to catch.

“We have the largest genome sequencing industry – we have about 50% of the world’s genome sequencing industry – and we are keeping a library of all the variants so that we are ready to respond – whether in the autumn or beyond – to any challenge that the virus may present and produce the next vaccine,” Zahawi said.

VACCINE RACE

The novel coronavirus – known as SARS-CoV-2 – has killed 2.268 million people worldwide since it emerged in China in late 2019, according to Johns Hopkins University of Medicine.

Israel is currently far ahead of the rest of the world on vaccinations per head of population, followed by the United Arab Emirates, the United Kingdom, Bahrain, the United States and then Spain, Italy and Germany.

Britain on Thursday launched a trial to assess the immune responses generated if doses of the vaccines from Pfizer and AstraZeneca are combined in a two-shot schedule.

The British researchers behind the trial said data on vaccinating people with the two different types of vaccines could help understanding of whether shots can be rolled out with greater flexibility around the world. Initial data on immune responses is expected to be generated around June.

The trial will examine the immune responses of an initial dose of Pfizer vaccine followed by a booster of AstraZeneca’s, as well as vice versa, with intervals of four and 12 weeks.

Both the mRNA shot developed by Pfizer and BioNtech and the adenovirus viral vector vaccine developed by Oxford University and AstraZeneca are currently being rolled out in Britain, with a 12-week gap between two doses of the same vaccine.

(Reporting by Guy Faulconbridge, Andy Bruce and Alistair Smout, editing by Estelle Shirbon and Nick Macfie)

White House plans to send vaccine doses to retail pharmacies

WASHINGTON (Reuters) – The White House will launch a new program shipping coronavirus vaccines directly to retail pharmacies starting next week in an effort to increase Americans’ access to shots, a top aide said on Tuesday.

President Joe Biden’s COVID-19 response coordinator, Jeff Zients, said the program will launch on Feb 11 and make 1 million doses available to 6,500 stores. As supply grows, the program could expand to as many as 40,000 stores, he said.

Biden said last month that the COVID-19 vaccine rollout has been a “dismal failure” so far and vowed to boost the speed at which shots are given to Americans, with a focus on ensuring equitable access regardless of geography, race, or ethnicity.

The federal government will distribute a million vaccine doses to the 6,500 stores next week, Zients said, adding that the amount will grow over time.

That is in addition to 10.5 million doses that the federal government plans to ship weekly to states and territories for the next three weeks, he added.

“This will provide more sites for people to get vaccinated in their communities,” Zients said, adding that supply constraints will limit the program in its early days.

The initial pharmacy locations were selected to improve access to vaccines in hard to reach areas and among socially vulnerable communities, Zients said.

CVS Health Corp said in a news release that its pharmacies will be participating in the program.

Zients also said the Federal Emergency Management Agency (FEMA) will reimburse states for some COVID-related costs they had taken on since the pandemic began last January, such as for personal protective equipment and deployment of the national guard.

He said Congress does not need to approve funds for FEMA to do this and that the total payments to states will be between $3 billion and $5 billion.

Zients added that the federal government has acquired supplies of equipment healthcare providers need to get six doses from each vial of Pfizer Inc’s COVID-19 vaccine rather than five.

The Biden administration has said it is willing to use emergency wartime powers if necessary to secure the specialized low dead space syringes and other supplies needed to eliminate vaccine waste and improve administration efficiency.

The major winter storm that hit the east coast of the United States this week has not disrupted vaccine deliveries but has forced some vaccine administration sites to shut down or reduce operating hours, Zients said.

(Reporting by Carl O’Donnell, Susan Heavey and Trevor Hunnicutt; Editing by Bill Berkrot)