COVID variant ‘taking over’ UK and likely to dominate elsewhere: expert

By Kate Kelland

LONDON (Reuters) – A coronavirus variant first found a few months ago in Britain is now “taking over” and causing 98% of all cases in the UK, the scientist leading the country’s variant-tracking research said on Thursday.

Sharon Peacock said the UK variant, known as B.1.1.7, also appears to be gaining a firm grip in many of the 100 or so other countries it has spread to in the past few months.

“It’s around 50% more transmissible – hence its success in really taking over the country,” said Peacock, director of the COVID-19 Genomics UK (COG-UK) consortium of scientists monitoring mutations in the coronavirus.

“We now know that it has spread across the UK and causes nearly all of the cases of COVID-19 – about 98%,” she told an online briefing for Britain’s Royal Society of Medicine.

“It appears to be the case that the other variants are not getting a foothold in this country.”

The B.1.1.7 variant, first detected in September 2020, has 23 mutations in its genetic code – a relatively high number of changes – and is thought by experts to be 40%-70% more transmissible than previously dominant variants.

Peacock also noted data released on Wednesday from a UK study which found that B.1.1.7 has “significantly higher” mortality, with death rates among those infected with it between 30% and 100% greater than among those infected with previous variants.

“There is a small increase in the likelihood of death from the variant,” she said.

The World Health Organization says B.1.1.7 is one of several “variants of concern,” along with others that have emerged in South Africa and Brazil. The variants are mutant versions of the SARS-CoV-2 virus that causes COVID-19, which has already killed more than 2.7 million people in the pandemic.

B.1.1.7 has spread to about 100 countries, according to WHO data, and some of those, including France, Denmark and the United States, have reported swift rises in the proportion of their COVID-19 cases being caused by it.

Peacock said evidence from the UK suggests B.1.1.7. is likely to become dominant elsewhere too.

“Because of its transmissibility, once it’s introduced, it does have that advantage over other circulating variants – so it is the case that B.1.1.7 appears to be travelling around the world and really expanding where it lands.”

Public Health England (PHE) also said on Thursday that a new coronavirus variant had been identified in the UK in two people who had recently been in Antigua. PHE said it shared some traits of other variants but was not classed as concerning for now.

(Reporting by Kate Kelland, Editing by William Maclean)

UK to prioritize next stage of COVID-19 vaccines by age, not job

By Alistair Smout

LONDON (Reuters) – Police and teachers will not jump to the head of the queue in the second phase of Britain’s COVID-19 vaccination rollout, with people instead prioritized by age, officials advising the government said on Friday, describing this as the best way to keep up the pace of immunizations.

Britain’s vaccine program has been among the fastest in the world, meeting a government target to offer a first dose of vaccination to 15 million high-risk people by mid-February.

Some frontline workers such as police and teachers had been calling for prioritization on the basis of their jobs, but Professor Wei Shen Lim, COVID-19 chairman for the Joint Committee on Vaccination and Immunization (JCVI), said such an approach could complicate the rollout.

“Following an age-based program will be simple, and simplicity has been one of the cornerstones of the current program in terms of speed and its success,” he told a news conference.

Britain aims to complete the first phase of its vaccine rollout by mid-April.

While the priority list for that phase was largely determined by age, with all over-50s set to be offered a vaccine, health and care workers and clinically vulnerable people have also been prioritized.

Announcing the prioritization list for phase 2, Lim said all those aged between 40-49 would be next in line for the shot, then those aged 30-39, then those aged 18-29.

The JCVI said that an age-based approach remained the most effective way of reducing death and hospitalization from COVID-19, even in those under 50. Giving shots by job would be logistically complex and could result in delays, it said.

The government said it would follow the recommended approach, but not everyone welcomed the advice.

John Apter, chairman of the Police Federation of England & Wales, said it was “a contemptible betrayal of police officers.”

“Their anger is palpable, this will not be forgotten.”

(Reporting by Alistair Smout; Editing by Michael Holden, Elizabeth Piper and Frances Kerry)

UK lowers COVID-19 alert status as pressure on hospitals eases

LONDON (Reuters) – The chief medical officers of the United Kingdom lowered their COVID-19 alert level on Thursday, citing a gradual reduction in pressure on the health service.

“Following advice from the Joint Biosecurity Center and in the light of the most recent data, the four UK Chief Medical Officers and NHS England National Medical Director agree that the UK alert level should move from level 5 to level 4 in all four nations,” Britain’s health ministry said in a statement.

Public health services in England, Scotland, Wales and Northern Ireland operate separately in most cases.

“The health services across the four nations remain under significant pressure with a high number of patients in hospital, however thanks to the efforts of public we are now seeing numbers consistently declining,” the medical officers added.

(Reporting by Andy Bruce, editing by David Milliken)

UK PM Johnson wants ‘cautious but irreversible’ path out of COVID-19 lockdown

By Guy Faulconbridge and Kate Holton

LONDON (Reuters) – British Prime Minister Boris Johnson said on Monday he would plot a cautious but irreversible path out of the COVID-19 lockdown this week after the vaccination of 15 million vulnerable people.

With nearly a quarter of the United Kingdom’s population now inoculated with a first dose of a COVID vaccine in a little over two months, Johnson is under pressure from some lawmakers and businesses to reopen the shuttered economy.

“We’ve got to be very prudent and what we want to see is progress that is cautious, but irreversible,” Johnson told reporters. “If we possibly can, we’ll be setting out dates.”

“If because of the rate of infection, we have to push off something a little bit to the right – delay it for a little bit – we won’t hesitate to do that.”

Johnson, due to set the path out of lockdown on Feb. 22, said the rates of infection were still high and too many people were still dying.

Asked if he would ensure schools reopened on March 8, Johnson said he would do everything he could to ensure that.

If many people get infected, there would be a high risk of mutation in the virus and higher risk of it spreading to older and more vulnerable groups, he said.

The biggest and swiftest global vaccine rollout in history is seen as the best chance of exiting the COVID-19 pandemic which has killed 2.4 million people, tipped the global economy into its worst peacetime slump since the Great Depression, and upended normal life for billions.

The United Kingdom has the world’s fifth-worst official death toll – currently 117,166 – after the United States, Brazil, Mexico and India.

VACCINE PASSPORTS?

Britain has vaccinated 15.062 million people with a first dose and 537,715 with a second dose, the fastest rollout per capita of any large country. Hancock said he expected vaccine supplies to increase as manufacturing accelerated.

An influential group of lawmakers in Johnson’s Conservative Party is urging an end to the lockdown as soon as the most vulnerable nine groups are vaccinated. They want no more rules beyond May 1.

“We’re all filled with sorrow for the people we’ve lost, the harms that we’ve suffered but we don’t honor those we’ve loved and lost by wrecking the rest of our lives,” lawmaker Steve Baker said. “We’ve got to find a way to rebuild our society and our economy and our prospects, our livelihoods.”

Britain is speaking to other countries about giving its citizens certificates showing they have been vaccinated so that they can travel abroad in the future to countries that require them, Johnson said.

“That’s going to be very much in the mix, down the road I think that is going to happen,” Johnson said, referring to such certificates. “What I don’t think we will have in this country is, as it were, vaccination passports to allow you to go to the pub, or something like that.”

(Reporting by Guy Faulconbridge and Kate Holton; Editing by Peter Graff, Nick Macfie and Bernadette Baum)

Exclusive: UK auditing Indian vaccine site amid scramble for shots-sources

By Neha Arora, Krishna N. Das and Euan Rocha

NEW DELHI (Reuters) – Britain’s drug regulator is auditing manufacturing processes at Serum Institute of India (SII) which could pave the way for AstraZeneca’s COVID-19 vaccine to be shipped from there to the UK and other countries, according to two sources close to the matter.

SII, the world’s largest vaccine manufacturer, is currently mass producing the AstraZeneca vaccine, developed in conjunction with Oxford University, for dozens of poor and middle-income countries but not the UK, which has been getting its supply of the shot primarily from domestic facilities.

If the UK’s Medicines and Healthcare products Regulatory Agency (MHRA) gives SII’s manufacturing process for the Oxford/AstraZeneca shot a greenlight it would allow the drug to be exported to the UK and to other countries which recognize MHRA’s clearances, one of the sources said.

Reuters could not determine what was the rationale for the audit. SII did not respond to a request for comment on it. The MHRA confirmed that an inspection was happening but declined further comment.

“Due to commercial confidentiality we do not comment on inspections that are still ongoing,” the regulator’s chief executive Dr. June Raine said in a statement to Reuters.

The two sources, who asked not to be named as the matter is private, said the audit should be relatively routine for SII, as its site already supplies other vaccines to the UK.

The inspection comes as countries around the world scramble to secure vaccine supplies amid supply disruptions and delivery cuts from leading drugmakers such as Pfizer Inc, Moderna and AstraZeneca.

It was not immediately clear whether an MHRA approval would allow the UK or AstraZeneca to route SII volumes of COVISHIELD – the brand name under which SII markets the AstraZeneca shot – to the EU, which has been pressuring the UK for supply from AstraZeneca’s facilities in the UK, amid shortages in Europe.

AstraZeneca executives told EU officials last week that to accelerate supplies to the bloc, it could provide it with some doses manufactured outside Europe, two EU sources told Reuters. One said the SII could be a supplier.

AstraZeneca, which has previously tapped SII to help fulfill some of its vaccine orders from Brazil, South Africa and Saudi Arabia, did not respond to a request for comment on whether it needs SII to help meet commitments in the UK, or in any other nations that would recognize an MHRA certification.

It was not immediately available to comment on the reported offer to supply the EU with shots from the SII.

INSPECTIONS

The EU’s drug regulator, the European Medicines Agency (EMA), audits sites from which it plans to source medicines but during the global pandemic, with multiple COVID-19 vaccines being developed, it is also partly leaning on inspections carried out by some other international regulators.

“Inspection outcomes for Covid-19 vaccines conducted by the MHRA will be considered by EMA,” said the regulator. Any such approved sites would also need an EMA sign off before they can export to the EU, the regulator told Reuters.

MHRA declined to comment on specifics, but Raine said it was collaborating “with international partners in response to the global pandemic and on matters of mutual interest.”

The UK has expressed an interest in purchasing vaccines from SII, according to the second source, along with a government official in New Delhi. The two sources said the volumes or timelines for any such purchases were unclear.

A UK government spokeswoman said: “Any discussions that have taken place between the UK Government and India on vaccines are not related to securing extra vaccine supply to the UK.”

The UK has so far ordered 100 million doses of AstraZeneca’s vaccine.

“Most countries have approached us and India’s government,” SII told Reuters, but it did not comment on any UK outreach. “We are trying our best to meet demand, and supply the vaccine to as many countries as possible, keeping India as the priority.”

SII’s chief executive, Adar Poonawalla, told Reuters in late January, his family-owned firm was keen to support AstraZeneca’s supply needs but its primary focus was on India and other poorer nations in Asia and Africa. He said at the time SII had no plans to divert supplies to Europe.

(Neha Arora and Krishna N.Das reported from New Delhi and Euan Rocha reported from Mumbai; Additional reporting by Paul Sandle, Kate Kelland and Alistair Smout in London, Francesco Guarascio in Brussels and Ludwig Burger in Frankfurt; Editing by Carmel Crimmins)

Nigerians win UK court OK to sue Shell over oil spills

By Julia Payne and Kirstin Ridley

LONDON (Reuters) – The UK Supreme Court on Friday allowed a group of 42,500 Nigerian farmers and fishermen to sue Royal Dutch Shell (RDS) in English courts after years of oil spills in the Niger Delta contaminated land and groundwater.

Senior judges said there was an arguable case that UK-domiciled Shell, one of the world’s biggest energy companies, is responsible, in the latest test of whether multinationals can be held to account for the acts of overseas subsidiaries.

Represented by law firm Leigh Day, the group of Nigerians have argued that the parent company Shell owed them a duty of care because it either had significant control of, and was responsible for, its subsidiary SPDC. Shell countered that the court had no jurisdiction to try the claims.

“(The ruling) also represents a watershed moment in the accountability of multinational companies. Increasingly impoverished communities are seeking to hold powerful corporate actors to account and this judgment will significantly increase their ability to do so,” Daniel Leader, partner at Leigh Day, said.

“UK common law is also used in countries like Canada, Australia and New Zealand so this is a very helpful precedent.”

The decision comes almost two years after a seminal ruling by the Supreme Court in a case involving mining firm Vedanta. The judgment allowed nearly 2,000 Zambian villagers to sue Vedanta in England for alleged pollution in Africa.

That move was seen as a victory for rural communities seeking to hold parent companies accountable for environmental disasters. Vedanta ultimately settled out of court in January.

Nigeria’s Ogale and Bille communities allege their lives and health have suffered because repeated oil spills have contaminated the land, swamps, groundwater and waterways and that there has been no adequate cleaning or remediation.

SPDC is the operator of oil pipelines in a joint venture between the Nigerian National Petroleum Corporation which holds a 55% stake, Shell which holds 30%, France’s Total with 10%, Italy’s Eni with 5%.

A Shell spokesman said the decision was disappointing.

“Regardless of the cause of a spill, SPDC cleans up and remediates. It also works hard to prevent these sabotage spills, by using technology, increasing surveillance and by promoting alternative livelihoods for those who might damage pipes and equipment,” Shell said.

Shell has blamed sabotage for oil spills. It said in its annual report published last March that SPDC, which produces around 1 million barrels of oil per day, saw crude oil spills caused by theft or pipeline sabotage surge by 41% in 2019.

Shell CEO Ben van Beurden said last week that the firm would take “another hard look at its onshore oil operations” in the west African country.

The ruling is the second judgement against Shell this year regarding claims against its Nigerian operations. In a landmark Dutch ruling two weeks ago, an appeals court held Shell responsible for multiple oil pipeline leaks in the Niger Delta and ordered it to pay unspecified damages to farmers, in a victory for environmentalists.

Leigh Day said that the amount of compensation sought would be quantified as the case enters the trial stage. Shell could however try to settle the matter out of court.

In 2015, Shell agreed to pay out 55 million pounds ($83.4 million) to the Bodo community in Nigeria in compensation for two oil spills, which was the largest ever out-of-court settlement relating to Nigerian oil spills.

(Reporting by Julia Payne and Kirstin Ridley; editing by John Stonestreet, William Maclean)

UK detects South African coronavirus variant in people with no travel links

By Reuters Staff

LONDON (Reuters) – Eleven people in different regions have tested positive for the South African coronavirus variant without having any links to people who have travelled recently, prompting mass testing in the areas to contain the outbreak.

The government said on Monday the cases were now self-isolating and robust contact tracing had taken place to trace their contacts and ask them to self-isolate.

Residents in eight postcodes – three in London; two in the south east and one in the West Midlands, east of England, and the North West – would now be tested for the new coronavirus whether they are showing any symptoms or not under what is known as “surge testing” it said.

“Every person over 16 living in these locations is strongly encouraged to take a COVID test this week, whether they are showing symptoms or not,” the government said in a statement.

The government said in January it had detected cases of both the South African and Brazilian variants, but all were linked to travel.

In total, Public Health England said it had identified 105 cases of the South African variant since Dec 22.

All viruses mutate frequently, and scientists have identified several variants of the novel coronavirus found to be more transmissible than the original strain.

The emergence of more infectious variants has raised questions over whether vaccines will prove as effective in containing them.

Scientists have said the South African variant appears to be more transmissible, but there is no evidence it causes more severe disease. But several laboratory studies have found that it reduces vaccine and antibody therapy efficacy.

Clinical trial data on two COVID-19 vaccines – from Novavax and Johnson & Johnson – released on Saturday showed they had less ability to protect against the illness caused by the South African variant.

But the Surrey Local Resilience Forum said there was no evidence the regulated vaccine would not protect against it. The Oxford-AstraZeneca and Pfizer-BioNTech vaccines are being rolled out across Britain.

UK offers Hong Kong residents route to citizenship, angering China

By Yew Lun Tian and William James

BEIJING/LONDON (Reuters) – Hong Kong residents can apply from Sunday for a new visa giving them the chance to become British citizens following China’s crackdown in the former colony, but Beijing said it will no longer recognize the special British passport already in use.

UK government forecasts say the new visa could attract more than 300,000 people and their dependents to Britain. Beijing said it would make them second-class citizens.

Britain and China have been arguing for months about what London and Washington say is an attempt to silence dissent in Hong Kong after huge pro-democracy protests in 2019 and 2020.

Britain says it is fulfilling a historic and moral commitment to the people of Hong Kong after Beijing imposed a new security law on the semi-autonomous city that Britain says breaches the terms of agreements under which the colony was handed back to China in 1997.

“I am immensely proud that we have brought in this new route for Hong Kong BN(O)s to live, work and make their home in our country,” Prime Minister Boris Johnson said, referring to a special British National Overseas (BNO) passport holders.

But China and the Hong Kong government hit back by saying they would no longer recognize the BNO passport as a valid travel document from Sunday, Jan. 31.

“Britain is trying to turn large numbers of Hong Kong people into second-class British citizens. This has completely changed the original nature of BNO,” Chinese foreign ministry spokesman Zhao Lijian told a briefing.

Beijing’s imposition of a national security law in Hong Kong in June last year prompted Britain to offer refuge to almost 3 million Hong Kong residents eligible for the BNO passport from Jan. 31.

The scheme, first announced last year, opens on Sunday and allows those with British National (Overseas) status to live, study and work in Britain for five years and eventually apply for citizenship.

BN(O) is a special status created under British law in 1987 that specifically relates to Hong Kong.

Britain’s foreign ministry said it was disappointed but not surprised by Beijing’s decision not to recognize the BNO passport. China’s move is largely symbolic as Hong Kong residents would not normally use their BNO passports to travel to the mainland. A BNO passport holder in Hong Kong could still use their Hong Kong passport or identity card.

The 250 pound ($340) visa could attract more than 300,000 people and their dependents to Britain and generate up to 2.9 billion pounds of net benefit to the British economy over the next five years, according to government forecasts.

It is still highly uncertain how many people will actually take up the offer.

China says the West’s views on its actions over Hong Kong are clouded by misinformation and an imperial hangover.

(Reporting by Yew Lun Tian and William James; Writing by Guy Faulconbridge; Editing by Angus MacSwan)

UK AstraZeneca vaccine plant partially evacuated over suspect package

LONDON (Reuters) – A factory in Wales that produces AstraZeneca’s COVID-19 vaccine was partially evacuated on Wednesday after it received a suspicious package and police said a bomb disposal unit was dealing with the incident.

Operated by Wockhardt UK, the plant provides so-called fill-and-finish capacity for AstraZeneca’s UK supply chain, which is the final manufacturing step of putting vaccines into vials or syringes and packaging them.

AstraZeneca has agreed to supply Britain with 100 million doses of the vaccine, developed by Oxford University.

It is currently engaged in a dispute with the European Union after it cut supplies to the bloc due to production issues at its Belgian factory.

“Wockhardt UK in Wrexham this morning received a suspicious package to site. All relevant authorities were immediately notified and engaged,” the company said, referring to its facility outside the town of Wrexham in north Wales.

“Upon expert advice we have partially evacuated the site pending a full investigation. The safety of our employees and business continuity remain of paramount importance,” it said.

Local police confirmed that a bomb disposal unit was on site and advised the public to avoid the area.

“We are currently dealing with an ongoing incident on the Wrexham Industrial Estate,” they said in a statement.

(Reporting by Alistair Smout, Michael Holden and Guy Faulconbridge; Editing by Estelle Shirbon and David Clarke)

UK plans tough new border measures to combat coronavirus

By William James and Michael Holden

LONDON (Reuters) – Britain will announce new tougher border measures on Wednesday to stop new variants of COVID-19 getting into the country, Prime Minister Boris Johnson said as he promised to deliver a roadmap out of lockdowns that have shuttered much of the economy.

The government is expected to bring in quarantine hotels for those coming to Britain from high-risk countries where new strains of the coronavirus have emerged – so-called red list nations – such as South Africa and those in South America.

The move comes as Britain’s death toll from COVID-19 surpassed 100,000, the first European state to reach that figure, leading to further questions about Johnson’s handling of the crisis.

“The Home Secretary (interior minister) will be setting out later today…even tougher measures for those red list countries where we are particularly concerned about new variants,” Johnson told parliament when asked about plans to strengthen Britain’s borders.

Britain saw infections soar at the end of last year after a highly-contagious new variant that emerged in southeast England surged through the population, taking cases and later deaths to record levels.

Since the start of January, all the United Kingdom has faced lockdowns which have closed schools, pubs and restaurants to all bar takeaways with the public told they must stay home as much as possible.

Johnson and his ministers have faced repeated questions, including from many in his own party, on when measures would be eased especially with regard to school closures. He told lawmakers he would address that issue later on Wednesday when he is due to host a media conference.

“Then in the course of the next few weeks, assuming the vaccine rollout continues well, assuming we don’t find new variants of concern…I will be setting out a broader roadmap for the way forward for the whole country,” he said.

With 100,162 recorded deaths, Britain has the world’s fifth highest toll from COVID-19 and the highest deaths per 100,000 people in the world.

Johnson said he felt deep sorrow about the loss of life when the figures were announced on Tuesday, but said the government had done everything it could.

Asked repeatedly by the leader of the Labor opposition Keir Starmer why Britain had fared so badly, he said there would be a time to learn the lessons of what happened but “I don’t think that moment is now” when 37,000 people were still in hospital suffering from the virus.

“There are no easy answers, perpetual lockdown is no answer,” he said.

(Additional reporting by Elizabeth Piper; Editing by Angus MacSwan)