Tag Archives: ethnic groups

Genes may add to ethnic COVID-19 disparities; sickest patients unwell a year later

By Nancy Lapid

(Reuters) – Here is a summary of some recent studies on COVID-19. They include research that warrants further study to corroborate the findings and that have yet to be certified by peer review.

Genes may explain some ethnic differences in COVID-19 impact

The varying impacts of COVID-19 among ethnic groups might be partially due to genetic differences in the cell-surface protein the virus uses as a gateway, an international research team found. They analyzed genetic information from more than 85,000 volunteers, including 6,274 who were tested for the new coronavirus and 1,837 who tested positive. In the gene for ACE2 – the “receptor” protein through which the virus breaks into cells – they found rare variants that would alter the part of the protein to which the virus attaches itself. These variant genes “appear to vary in frequency between different ethnic groups,” said Jamal Nasir of the University of Northampton in the UK. Two were more common in Europeans than in East Asians, for example. Nasir and colleagues also found variants that appear to increase or decrease an individual’s ACE2 protein levels, which could affect vulnerability to infection, or severity. People who were not infected with the coronavirus were more likely to have a variant that decreases ACE2 levels, according to a report posted on Wednesday on medRxiv ahead of peer review. The next steps, Nasir said, are to confirm the findings by exposing human cells to the virus in lab experiments and to identify small molecules that can be used as drugs to block harmful genetic mutations’ effects.

Severe COVID-19 still affects patients a year later

Among 1,276 COVID-19 patients hospitalized in China early in the pandemic, 49% still had at least one symptom 12 months after first becoming ill, researchers reported on Friday in The Lancet. Most common were fatigue or muscle weakness. About a third still had shortness of breath or other lung problems, especially those who had been the most severely ill. In some patients, doctors saw a reduced flow of oxygen from the lungs to the bloodstream. Roughly one in four survivors reported depression. Among patients who had been employed before they were hospitalized, 88% had returned to work by 12 months – but overall, the survivors were not as healthy as people from the community who had not been infected with the coronavirus. The study only looked at patients from one hospital, and not many of them had been sick enough to require intensive care. Nevertheless, the fact that some patients still had symptoms “should be taken into account when planning delivery of healthcare services post-pandemic,” coauthor Bin Cao from the China-Japan Friendship Hospital said in a statement.

Pfizer vaccine safe in small study of very sick kids

In adolescents with serious neurological conditions, the side effects of the Pfizer/BioNTech vaccine are likely to be mild to moderate and clear up quickly, a small study suggests. The 27 children in the study, ages 12 to 15, had muscular dystrophy, cerebral palsy, or other neurological diseases, plus other conditions such as heart defects and immune deficiency – all of which put them at very high risk for severe COVID-19. They would not have been included in the main trials of the vaccine because they were too sick, the researchers said. Eleven children had averse events after the first or second dose, such as mild rash, fever, headache, gastrointestinal upset, difficulty sleeping, and low blood sugar. Most problems resolved within 72 hours, and the rest cleared up within a week, according to a report published on Thursday in Archives of Disease in Childhood. Although the study involved only a few children, “these data are especially important as they are representative of the children who are most likely to benefit from vaccination, and parents and clinicians may have concerns regarding an increased risk of unexpected events,” the authors said.

(Reporting by Nancy Lapid; Editing by Tiffany Wu)

China’s Xi says ‘happiness’ in Xinjiang on the rise, will keep teaching ‘correct’ outlook

SHANGHAI (Reuters) – Chinese President Xi Jinping said levels of happiness among all ethnic groups in the western region of Xinjiang are rising and that China plans to keep teaching its residents a “correct” outlook on China, Xinhua news agency reported late on Saturday.

China has come under scrutiny over its treatment of Uighur Muslims and claims of alleged forced-labor abuses in Xinjiang, where the United Nations cites credible reports as saying one million Muslims held in camps have been put to work.

China has repeatedly denied mistreating Uighurs and says the camps are vocational training centers that are needed to tackle extremism, accusing what it calls anti-China forces of smearing its Xinjiang policy.

“The sense of gain, happiness, and security among the people of all ethnic groups (in Xinjiang) has continued to increase,” Xi told a ruling Communist Party conference on Xinjiang held on Friday and Saturday, Xinhua said.

Xi said it was necessary to educate Xinjiang’s population on an understanding of the Chinese nation and guide “all ethnic groups on establishing a correct perspective on the country, history and nationality”.

“Practice has shown that the party’s strategy for governing Xinjiang in the new era is completely correct” and it should be a long-term approach, he added.

In July, Washington imposed sanctions on Chinese officials over alleged human rights abuses against Uighurs under the Global Magnitsky Act, which allows the U.S. government to target human rights violators by freezing any U.S. assets, banning U.S. travel and prohibiting Americans from doing business with them.

(Reporting by Engen Tham; Editing by Tony Munroe and Nick Macfie)

Nigeria holds mass burial for 73 people killed in communal violence

People cry as a truck carries the coffins of people killed by the Fulani herdsmen, in Makurdi, Nigeria January 11, 2018.

By Alexis Akwagyiram

MAKURDI, Nigeria (Reuters) – Seventy-three people killed since the start of the year in communal violence between semi-nomadic herdsmen and farmers were buried in Nigeria on Thursday highlighting a bloody conflict over fertile land that is taking on political significance.

The mass burial took place in Makurdi, in the central state of Benue, where thousands of mourners took to the streets to watch the funeral procession. The killings occurred in remote parts of Benue, the state worst hit by clashes that have killed at least 83 people since Dec. 31.

Thousands of herdsmen mainly from the Fulani ethnic group have moved southwards in the last few years to flee spreading desertification in the north, putting pressure on dwindling fertile land amid rapid population growth.

The spike in violence has become increasingly political ahead of elections in February 2019 with critics of President Muhammadu Buhari, who is Fulani, accusing him of failing to get tough with the herdsmen.

Feelings ran high on the streets of Makurdi where thousands of people, many clad in black, waved wreaths as coffins on lorries passed by carrying the dead who were mainly from rural communities of Benue.

Some mourners held banners featuring pictures of victims and the words: “President act now: your people are killing us”.

“Something that is disturbing that I have heard about is linking those developments to the fact that a Fulani man is president and so, he is brooking such kind of evil acts,” said the president’s spokesman, Femi Adesina, this week, adding that such violence predated Buhari’s administration.

The herdsmen are mostly Muslim and the settled farmers are often Christian.

Despite the recent outbreaks of violence, Nigerians, split roughly equally between Christians and Muslims from around 250 different ethnic groups, mostly live peacefully together.

Clashes in the last few months have occurred in parts of the northwest and southeast, but the middle belt – where differing religious, ancestral and cultural differences frequently ignite conflict – has been worst hit in the latest flashpoints.

Peter Zion,31, a member of a state government task force set up to defend farms, was recuperating in hospital after being shot and cut across his face and torso by herdsmen wielding guns and cutlasses on Jan. 2 in the state’s Guma district.

“They killed some of my colleagues and the neighbors that were there all died,” said the father-of-two whose face had been cut and whose hands and legs were heavily bandaged. He described attackers going door-to-door shooting people.

The executive secretary of the Benue emergency agency, Emmanuel Shior, on Thursday said around 80,000 people who had fled herdsmen attacks were living in four camps located across the state.

Herdsmen traditionally roam freely across West Africa, entering and leaving Nigeria through porous borders with Benin, Niger and Cameroon. They have also accused Nigerian farmers of violent attacks in the last few years.

Improving security was a key promise in Buhari’s successful 2015 presidential election campaign. The 75-year-old has not yet said whether he will seek re-election next year.

“Security of life and property continues to be top of our agenda, in line with our election pledge and promises,” said Buhari in a tweet on Thursday, which linked to a list of ways in which the government has responded to the killings.

He bolstered the police presence in Benue on Monday and ordered the head of police to relocate to the state.

The violence is likely to further stretch security forces already contending with Boko Haram’s Islamist insurgency in the northeast and the threat of attacks on oil facilities in the southern Niger Delta of the type that in 2016 helped to push Africa’s largest economy into recession.

(Additional reoporting by Anamesere Igboeroteonwu in Onitsha and Felix Onuah in Abuja; Editing by Richard Balmforth)