Mutating Mpox strain is quickly spreading and doctors are working blind

mpox-virus

Important Takeaways:

  • Scientists studying the new mpox strain that has spread out of Democratic Republic of Congo say the virus is changing faster than expected, and often in areas where experts lack the funding and equipment to properly track it.
  • That means there are numerous unknowns about the virus itself, its severity and how it is transmitting, complicating the response, half a dozen scientists in Africa, Europe and the United States told Reuters.
  • A new strain of the virus, known as clade Ib, has the world’s attention again after the WHO declared a new health emergency.
  • The strain is a mutated version of clade I, a form of mpox spread by contact with infected animals that has been endemic in Congo for decades. Mpox typically causes flu-like symptoms and pus-filled lesions and can kill.
  • Congo has had more than 18,000 suspected clade I and clade Ib mpox cases and 615 deaths this year, according to the WHO. There have also been 222 confirmed clade Ib cases in four African countries in the last month, plus a case each in Sweden and Thailand in people with a travel history in Africa.

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Mpox: Africa’s CDC poised to declare for first time ever a “public health emergency of continental security”

Testing-for-Mpox

Important Takeaways:

  • The Africa Centers for Disease Control and Prevention has never done anything like this before.
  • Since the beginning of last year, mpox cases have been surging in the Democratic Republic of Congo, with children making up the majority of the 14,000 reported cases and 511 deaths so far in 2024.
  • In the last couple weeks, there’s been a new and alarming development. Mpox has been detected in countries that have never previously identified cases.
  • It is with past health emergencies in mind that Africa CDC is trying to move quickly and garner international support.
  • The World Health Organization has also taken note of the evolving mpox situation. This week it announced that the group is convening an emergency committee to determine whether it will make a similar declaration to that of Africa CDC, designating the situation a public health emergency of international concern. “The committee will meet as soon as possible,” says WHO head Tedros Adhanom Ghebreyesus.
  • There’s concern about mpox in the U.S. as well. The U.S. Centers for Disease Control and Prevention issued an mpox health alert this week.

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Little food and water for Congolese fleeing volcano

By Djaffar Al Katanty

SAKE, Democratic Republic of Congo (Reuters) -Families fleeing a volcano eruption in eastern Democratic Republic of Congo said on Friday they were struggling to find enough food and water as the United Nations called for aid and warned about the risk of cholera.

At least 31 people died when Mount Nyiragongo sent a wall of lava spreading towards Goma on Saturday last week, destroying 3,000 homes along the way and cutting a major road used to bring aid to the strife-torn region.

The lava stopped just short of the city limits, but thousands more people fled early on Thursday when the government warned that the volcano, one of the world’s most active, could erupt again.

Many escaped to Sake, a town 13 miles (20 km) northwest of Goma that is prone to cholera outbreaks, UNICEF said.

People slept wherever they could – on the side of the road and inside classrooms and a church. Kabuo Asifiwe Muliwavyo, 36, told Reuters she and her seven children had not eaten since arriving on Thursday.

“They told us that there will be a second eruption and that there will be a big gas explosion,” she said as she cradled her crying one-year-old. “But since we moved, there is nothing here … We are starving.”

Around 400,000 people need support or protection, the U.N. children’s fund (UNICEF) said in a statement.

“With an increased risk of a cholera outbreak, we are appealing for urgent international assistance to avert what could be a catastrophe for children,” UNICEF’s representative in Congo, Edouard Beigbeder, said.

UNDER THE STARS

Danga Tungulo and his four children slept next to the road in Sake. Some local residents brought them water, but they had not eaten since they left Goma the previous day, he said.

“They told everyone that assistance would be organized, that money would be disbursed by the government,” said Hassan Kanga, a lawyer who fled after the eruption. “And yet, you find us under the stars.”

The evacuation order was issued around 1 a.m. local time on Thursday after radar images showed molten rock flowing under Goma.

The movement of magma caused cracks in the ground and hundreds of earthquakes, which could allow it to burst through to the surface in a fresh eruption, the Goma Volcano Observatory (OVG) said.

The frequency and intensity of the ground tremors had lessened in the last 24 hours, suggesting the risk of a fresh eruption was subsiding, Celestin Kasareka Mahinda of the OVG said on Friday.

“I don’t think we will have a second eruption. The problem is the risk of fractures, but the risk is small, around 20%,” he told Reuters.

Some people who had fled to Sake crowded into trucks later on Friday to return to Goma. Dozens of people who had fled in the opposite direction to neighboring Rwanda also crossed back into Congo, photos shared by the Rwandan government showed.

Congolese authorities, meanwhile, reopened the main road which was split in two by lava, the U.N. Office for Coordination of Humanitarian Affairs (OCHA) said on Thursday.

Goma is major humanitarian hub supplying aid to a region hit by decades of unrest.

(Reporting by Djaffar Al Katanty, Aaron Ross and Hereward Holland; Writing by Hereward Holland; Editing by Aaron Ross and Andrew Heavens)

More than 200,000 flee “apocalyptic” conflict in Central African Republic

By Emma Farge

GENEVA (Reuters) – More than 200,000 people have fled fighting in the Central African Republic (CAR) since violence erupted over a December election result, the U.N. refugee agency (UNHCR) said on Friday, with nearly half crossing into the Democratic Republic of Congo.

The CAR army, backed by U.N., Russian and Rwandan troops, has been battling rebels seeking to overturn a Dec. 27 vote in which President Faustin-Archange Touadera was declared the winner.

“Refugees have told UNHCR that they fled in panic when they heard gun shots, leaving their belongings behind,” spokesman Boris Cheshirkov told journalists in Geneva.

The nation of nearly five million people, larger than mainland France, Belgium and Luxemburg combined and rich in diamonds, timber and gold, has struggled to find stability since a 2013 rebellion ousted former president Francois Bozize.

The current fighting between a coalition of militias on the one side and the national army and its backers on the other was sparked by a Constitutional Court decision to bar Bozize’s candidacy in the Dec. 27 presidential election.

Former prime minister Martin Ziguele, who came third in the Dec. 21 election, said on Friday there was fighting across the country every day, preventing movement between towns, and pushing more people to flee.

“Everyone is focused on the main transport route between the capital and eastern Cameroon for supplies, but inside the country, there is no movement,” Ziguele told Reuters by phone from Bangui.

“I cannot leave Bangui and go 90 km (60 miles) without a heavily-armed army escort. Imagine then the population. Add the curfew and the state of emergency, it is really an apocalyptic situation,” Ziguele said.

SEX FOR FOOD

About 92,000 refugees have reached DRC and more than 13,000 have crossed into Cameroon, Chad and the Republic of Congo. The rest are displaced inside the Central African Republic, the UNHCR said.

Ongoing attacks has hampered humanitarian access and the main road used to bring supplies has been forced shut inside the country and many are now facing “dire conditions,” UNHCR’s Cheshirkov said.

Some of the displaced are so desperate they have agreed to sex in return for food, he added. Malaria, respiratory tract infections, and diarrhea have become common.

He also voiced concern about the reported presence of armed groups in the Batangafo and Bria camps for the displaced.

“Those armed groups are trying in some cases to restrict movements and in some cases forcibly recruit. So this is a very concerning situation,” he told the briefing.

Ziguele said that while a substantial increase in peacekeepers, as requested by the U.N. envoy in Bangui, was welcomed, a dialogue between all parties was urgently needed.

“A military surge is not the only solution to tackle the security, humanitarian and economic crisis that is threatening to put one of the world’s least developed countries into a complete coma,” he said.

(Reporting by Emma Farge, additional reporting by Bate Felix in Dakar; editing by Stephanie Nebehay and Philippa Fletcher)

Ebola death toll in east Congo outbreak climbs above 2,000

FILE PHOTO: A health worker fills a syringe with Ebola vaccine before injecting it to a patient, in Goma, Democratic Republic of Congo, August 5, 2019. REUTERS/Baz Ratner/File Photo

By Djaffar Al Katanty and Aaron Ross

GOMA, Democratic Republic of Congo (Reuters) – The death toll from Democratic Republic of Congo’s year-long Ebola outbreak has climbed above 2,000, government data showed on Friday, as responders battle to overcome community mistrust and widespread security problems.

The death in neighboring Uganda of a 9-year-old girl who had tested positive for the virus after entering the country from Congo underscored the challenge medical teams face containing the disease in border territory with a highly mobile population.

The government team overseeing the response said the number of confirmed and probable cases had also hit a milestone of more than 3,000 in what has become the second-worst epidemic of the virus on record.

Despite the development of an effective vaccine and treatments, health workers have struggled to stop the virus spreading in remote and conflict-hit areas of eastern Congo, where many locals are wary of the response effort.

Nevertheless, the World Health Organization said the latest Uganda case highlighted the border authorities’ skill at detecting and isolating potential sources of transmission.

“This case was picked up at the border,” WHO spokeswoman Fadela Chaib said at a briefing in Geneva. “The people who are at the borders have the expertise.”

This is Congo’s 10th Ebola outbreak, but it is the first in the densely forested hillside provinces of North Kivu and Ituri, where militia-led violence and ethnic killing have undermined security in certain areas for decades.

The WHO declared the epidemic an international health emergency in July – only the fifth outbreak to warrant this status since the system was introduced in 2005.

The authorities have since come up against new fronts in their fight to contain the virus, testing the reach and flexibility of responders.

Health workers confirmed the first cases in South Kivu province on Aug. 16. Soon after, a woman contracted the virus in a remote, militia-controlled territory in North Kivu, hundreds of kilometers away from other known cases.

“The response is being spread too thin chasing new cases at the expense of the longer-term community engagement that is crucial if we’re ever to hope of being Ebola free,” Oxfam’s Congo Director Corinne N’Daw said in a statement.

Despite the virus spreading to new areas, the past week’s transmission rate was little changed from that of the past month and a half, which has seen an average of 77 new cases per week, according to the WHO.

Last week the WHO voiced concern about the widening geographic reach of the disease, but confirmed the virus had not gained a foothold in the major city of Goma, even after four cases were recorded there in July and early August.

Goma, a lakeside city of nearly 2 million people on the Rwandan border, had been on high alert for weeks after a gold miner with a large family infected several people with Ebola before dying himself.

The latest government data showed Ebola deaths reaching 2,006 and cases at 3,004.

“Two thousand deaths means that there is a problem,” said Timothée Buliga, a priest, returning home from his church in Goma. “We need to reach the point where we reject Ebola, say no and eradicate it definitively.”

Only the 2013-2016 Ebola outbreak in West Africa has been deadlier than the current outbreak. More than 11,300 people died then out of the 28,000 who were infected.

(Additional reporting by Tom Miles and Stephanie Nebehey in Geneva; Elias Biryabarema in Kampala; Writing by Alessandra Prentice; Editing by Kirsten Donovan and Hugh Lawson)

Congolese cross-border trader’s Ebola death fuels Uganda outbreak fears

FILE PHOTO: A Congolese health worker prepares to administer Ebola vaccine, outside the house of a victim who died from Ebola in the village of Mangina in North Kivu province of the Democratic Republic of Congo, August 18, 2018. REUTERS/Olivia Acland/File Photo

By Tom Miles

GENEVA (Reuters) – A Congolese woman who died of Ebola this month vomited four times in a Ugandan market after crossing the border days earlier to sell fish, the WHO said, fuelling fears that the virus may be spreading beyond the Democratic Republic of Congo.

The current outbreak of the highly infectious disease has been all but confined to Congo, killing 1,673 people there – more than two-thirds of those who contracted it – over the past year, and three in Uganda last month.

A World Health Organization panel is debating whether to declare the outbreak “of international concern”, a designation that the agency’s head suggested a case this month in the large Congolese city of Goma had made more likely.

The fisherwoman traveled across the border to Mpondwe market on July 11, according to a Ugandan Health Ministry report published on Wednesday by the WHO.

It said 19 fishmongers were listed as having had possible contact with her while another 590 could be targeted for vaccination.

The health response to the virus relies on tracking down and testing people who may have been exposed to it and vaccinating them and anybody they have had contact with.

Ugandan and Congolese officials were working to find people who might have been put at risk by the dead woman, who appeared to have used an illegal border crossing, health ministry spokesman Emmanuel Ainebyona said.

So far “no one has been found to be positive of the Ebola virus. The team is still monitoring the tested traders,” he said.

The report said health workers had not established where the fishmonger spent nights, who transported her merchandise and who cleaned up her vomit.

The Ministry and the WHO said there were currently no confirmed Ebola cases in Uganda.

The WHO’s emergency committee of international experts were meeting on Wednesday for a fourth time to consider if the 11-month outbreak constituted a “public health emergency of international concern” (PHEIC), and will announce their decision at 1700 GMT.

A PHEIC declaration would be just the fifth in WHO history and include recommendations for international action. It could also help unlock sorely needed funds.

Last month the committee decided the potential disruption of declaring one risked causing economic harm while achieving nothing.

But WHO chief Tedros Adhanom Ghebreyesus said this week that the case in Goma was a potential game-changer since it meant Ebola might now spread among the urban population and into neighboring Rwanda.

A separate WHO report cited a very high risk for Uganda’s Arua district, which borders a Congolese area where an Ebola patient died after having had contact with over 200 people. Two deaths in Arua were under investigation.

(Reporting by Tom Miles and Nairobi newsroom; Editing by Gareth Jones and John Stonestreet)

Family sent back to DR Congo after two die of Ebola in Uganda

A health worker checks the temperature of a woman as she crosses the Mpondwe border point separating Uganda and the Democratic Republic of Congo as part of the ebola screening at the computerised Mpondwe Health Screening Facility in Mpondwe, Uganda June 13, 2019. REUTERS/Newton Nabwaya

By Elias Biryabarema

KAMPALA (Reuters) – Authorities repatriated the relatives of two people who died of Ebola in Uganda back to the Democratic Republic of Congo on Thursday, including a 3-year-old boy confirmed to be suffering from the disease, the Ugandan health minister said.

The cases marked the first time the virus has crossed an international border since the current outbreak began in Congo last August. The epidemic has already killed 1,390 people in eastern Congo.

The family sent home on Thursday had crossed from Congo to Uganda earlier this week and sought treatment when a 5-year-old boy became unwell. He died of Ebola on Tuesday. His 50-year-old grandmother, who was accompanying them, died of the disease on Wednesday, the ministry said.

They were the first confirmed deaths in Uganda in the current Ebola outbreak.

The dead boy’s father, mother, 3-year-old brother and their 6-month-old baby, along with the family’s maid, were all repatriated, the minister’s statement said.

The 3-year-old has been confirmed to be infected with Ebola. His 23-year-old Ugandan father has displayed symptoms but tested negative, Ugandan authorities said.

“Uganda remains in Ebola response mode to follow up the 27 contacts (of the family),” the statement said.

Three other suspected Ebola cases not related to the family remain in isolation, the ministry said.

The viral disease spreads through contact with bodily fluids, causing hemorrhagic fever with severe vomiting, diarrhea and bleeding.

UGANDA PRECAUTIONS

Authorities in neighboring Uganda and South Sudan have been on high alert in case the disease spreads.

On Thursday, Uganda banned public gatherings in the Kasese district where the family crossed the border. Residents are also taking precautions, local journalist Ronald Kule told Reuters.

“They are a little alarmed now and they realize that the risk of catching Ebola is now real,” he said.

“Hand washing facilities have been put in place, with washing materials like JIK (bleach) and soap. There’s no shaking of hands, people just wave at each other.”

At the border, health workers checked lines of people and isolate one child with a raised temperature, a Reuters journalist said.

Uganda has already vaccinated many frontline health workers and is relatively well prepared to contain the virus.

The World Health Organization (WHO) sent 3,500 doses of a Merck experimental vaccine to Uganda this week, following 4,700 initial doses.

Dr. Mike Ryan, head of WHO’s emergencies program, said that he expected Uganda to approve the use of experimental therapeutic drug treatments, to be shipped “in coming days”.

Monitoring and vaccination had been stepped up, but there had been “no panic reaction” so far to the cases there.

The WHO has said it will reconvene an emergency committee on Friday to decide whether the outbreak is an international public health emergency and how to manage it.

Authorities have struggled to contain the disease partly because health workers have been attacked nearly 200 times this year in conflict-hit eastern Congo, the epicenter of the outbreak.

(Reporting by Elias Biryabarema; Writing by Omar Mohammed and Katharine Houreld; Editing by Angus MacSwan)

Congo Ebola death toll nears 1,000, new vaccine planned -WHO

Mike Ryan, Executive Director of the World Health Organisation (WHO) attends a news conference on the Ebola outbreak in the Democratic Republic of Congo at the United Nations in Geneva, Switzerland May 3, 2019. REUTERS/Denis Balibouse

By Stephanie Nebehay

GENEVA (Reuters) – The World Health Organization said on Friday it feared continued “intense transmission” of Ebola virus in the Democratic Republic of Congo, where deaths from a nine-month-old epidemic stood at 994 and were expected to exceed 1,000 within hours.

The WHO plans to expand vaccination with an unlicensed new Ebola vaccine made by Johnson & Johnson, in addition to a Merck vaccine already being used, said Dr. Michael Ryan, executive director of WHO’s Health Emergencies Programme.

“We are anticipating a scenario of continued intense transmission,” Ryan told a news briefing.

“We haven’t exceeded the 1,000 (deaths) as of this morning but we will likely exceed that today when we see the numbers later this evening. We want to use every tool in the tool box.”

Security incidents continue to plague the response to the outbreak, with 119 since January alone, Ryan said. This curtails access and thereby slows efforts to vaccinate more than 900 people a day as well as daily checks on some 12,000 people potentially exposed to the virus, he said.

“We still face major issues of community acceptance and trust,” Ryan added.

There was a would-be assault on an Ebola treatment facility in Butembe on Thursday, he said, adding that nobody was injured and the assailants were captured.

(Reporting by Stephanie Nebehay; Editing by Mark Heinrich)

Ebola spread concentrated in Congo, not a wider emergency: WHO

FILE PHOTO: Health workers carry a newly admitted confirmed Ebola patient into a treatment centre in Butembo in the eastern Democratic Republic of Congo, March 28, 2019. REUTERS/Baz Ratner

By Stephanie Nebehay and Kate Kelland

GENEVA/LONDON (Reuters) – An outbreak of Ebola in the Democratic Republic of Congo (DRC) that has killed more than 700 people and is continuing to spread does not constitute an international emergency, the World Health Organization said on Friday.

Declaring the epidemic a “public health emergency of international concern” would have signaled that greater resources and international coordination are needed.

The WHO’s independent Emergency Committee, which analyzed the latest data, said the disease was entrenched in several epicenters in the northeast and was being transmitted in health care settings.

It had not spread across borders to Uganda, Rwanda or South Sudan, but neighboring countries should shore up their preparedness, the experts said.

“It was an almost unanimous vote that this would not constitute a PHEIC (public health emergency of international concern) because we are moderately optimistic that this outbreak can be brought into control – not immediately, but still within a foreseeable time,” panel chairman Professor Robert Steffen told a news conference.

Dozens of new cases reported this week have been mainly in the epicenters of Butembe, Katwe and Vuhovi, said Mike Ryan, head of the WHO’s health emergencies program.

“It’s quite a focused amplification of disease in a very specific geographic area,” Ryan said.

“But the disease there has risen because of lack of access to that community, we’ve fallen behind in starting vaccination rings,” he said, referring to attacks on health centers by armed groups in February that cut-off hotspot areas.

“Vaccine is proving to be a highly effective way of stopping this virus but if we can’t vaccinate people we cannot protect them,” he added, noting that nearly 100,000 people have been vaccinated.

Experts have declared four emergencies in the past decade: the H1N1 virus that caused an influenza pandemic (2009), a major Ebola outbreak in West Africa (2014), polio (2014) and Zika virus (2016).

Some experts expressed concern that the Emergency Committee was too narrowly interpreting WHO guidelines.

“This is a deeply concerning event, due to the pathogen itself, the total number of cases, the increase in cases just this week, and the difficulty of coordinating the response due to conflict – that needs to receive the appropriate level of attention,” health experts Rebecca Katz and Alexandra Phelan of Georgetown University in Washington D.C. said in a statement.

The Ebola outbreak – by far the biggest Congo has seen, and the world’s second largest in history – was declared by national authorities in August. It is concentrated in Congo’s North Kivu and Ituri provinces.

It has already infected at least 1,206 people, of whom 764 have died – giving a death rate of 63 percent.

They include 20 new cases reported by the health ministry on Thursday, another one-day record after 18 on Wednesday. Two workers at the Butembo airport tested positive, it said.

(Reporting by Stephanie Nebehay and Kate Kelland Additional reporting by Aaron Ross in Dakar; Editing by Hugh Lawson and Frances Kerry)

Uganda makes arrests in kidnap of American tourist and her guide

U.S. tourist Kimberly Sue Endicott poses with her guide, Jean Paul Mirenge in Uganda, April 7, 2019, in this image taken from social media. Wild Frontiers/via REUTERS

By Elias Biryabarema

KAMPALA (Reuters) – Uganda said Tuesday some suspects had been arrested in connection with last week’s kidnap of an American tourist and her tour guide in a national park while a minister told a local TV that a ransom had been paid to free them.

Tourist Kimberley Sue Endecott, 35, and guide Jean Paul Mirenge-Remezo were ambushed and seized by gunmen as they drove in Queen Elizabeth National Park in the country’s southwest near the border with Democratic Republic of Congo on April 2.

It’s one of Uganda’s most visited parks, home to antelopes, lions, elephants, hippos, crocodile and leopards.

The kidnappers later demanded a ransom of $500,000. On Sunday Ugandan security officials said they had rescued the pair unharmed near the border.

In a statement on Tuesday, police said: “The joint security team actively investigating the kidnapping incident … has made some arrests of suspects, on suspicion of being involved.”

Police did not give details about the suspects but said they had been detained during “raids and extensive searches” in Kanungu district, more than 400 km (250 miles) southwest of the capital Kampala.

On Tuesday, junior tourism minister, Godfrey Kiwanda Ssubi, told NBS TV that a ransom was paid to secure the victims.

“Whatever these people (kidnappers) demanded for was paid,” Ssubi said.

“The money had to be taken … everything was done to save the lives of these people.”

Ugandan security officials had earlier refused to acknowledge the payment despite several reports in local and international media.

The United States has maintained it follows a policy of no concessions to kidnappers although the tour firm that arranged the safari told Reuters the captives were released after a “negotiated settlement” with the assistance of the US government.

In a tweet on Monday, U.S. President Donald Trump urged Ugandan authorities to find the perpetrators and bring them to justice “openly and quickly”.

(Reporting by Elias Biryabarema; Editing by Giles Elgood)