Exclusive: Oxford study indicates AstraZeneca effective against Brazil variant, source says

By Rodrigo Viga Gaier

RIO DE JANEIRO (Reuters) – Preliminary data from a study conducted at the University of Oxford indicates that the COVID-19 vaccine developed by AstraZeneca PLC is effective against the P1, or Brazilian, variant, a source with knowledge of the study told Reuters on Friday.

The data indicates that the vaccine will not need to be modified in order to protect against the variant, which is believed to have originated in the Amazonian city of Manaus, said the source, who requested anonymity as the results have not yet been made public.

The source did not provide the exact efficacy of the vaccine against the variant. They said the full results of the study should be released soon, possibly in March.

Early results indicated the AstraZeneca vaccine was less effective against the South African variant, which is similar to P1. South Africa subsequently paused the use of the vaccine in the country.

The information comes as a small-sample study suggested the COVID-19 vaccine developed by China’s Sinovac may not work effectively against the Brazilian variant.

Responding to a request for comment, Fiocruz, which sent the samples that formed the basis of the study, told Reuters it did not have any information on the study, as it was being led by AstraZeneca and the University of Oxford.

Representatives for AstraZeneca and the University of Oxford did not immediately respond to requests for comment.

Brazil is currently confronting a brutal and long-lasting second wave of the coronavirus, hitting a daily record of 1,910 deaths on Wednesday.

The P1 variant is among the factors that epidemiologists believe is contributing to a rise in cases and deaths, and there has been concern in the scientific community about the variant’s resistance to vaccines.

(Reporting by Rodrigo Viga Gaier; Writing by Gram Slattery; Editing by Hugh Lawson)

WHO investigators to scrap interim report on probe of COVID-19 origins: WSJ

(Reuters) – A World Health Organization team investigating the origins of COVID-19 is planning to scrap an interim report on its recent mission to China amid mounting tensions between Beijing and Washington over the investigation and an appeal from one international group of scientists for a new probe, the Wall Street Journal reported on Thursday.

In Geneva, WHO spokesman Tarik Jasarevic said in an email reply: “The full report is expected in coming weeks”.

No further information was immediately available about the reasons for the delay in publishing the findings of the WHO-led mission to the central Chinese city of Wuhan, where the first human cases of COVID-19 were detected in late 2019.China refused to give raw data on early COVID-19 cases to a WHO-led team probing the origins of the pandemic, Dominic Dwyer, one of the team’s investigators said last month, potentially complicating efforts to understand how the outbreak began.

The probe had been plagued by delays, concern over access and bickering between Beijing and Washington, which accused China of hiding the extent of the initial outbreak and criticized the terms of the visit, under which Chinese experts conducted the first phase of research.

The team, which arrived in China in January and spent four weeks looking into the origins of the outbreak, was limited to visits organized by their Chinese hosts and prevented from contact with community members, due to health restrictions. The first two weeks were spent in hotel quarantine.

(Reporting by Aishwarya Nair in Bengaluru and Stephanie Nebehay in Geneva; Editing by Chizu Nomiyama and Bernadette Baum)

Coronavirus crisis in Latin America made worse by poverty, inequality, U.N. agency says

By Fabian Cambero

SANTIAGO (Reuters) – Latin America and the Caribbean countries in the throes of the coronavirus crisis will only see their problems made worse by festering inequality, poverty and an ailing social safety net, a United Nations agency said on Thursday.

The Economic Commission for Latin America and the Caribbean (ECLAC) said social unrest was on the rise across the region, a sign that immediate action was necessary to aid hard-hit countries struggling long before the pandemic hit.

“The effects of the coronavirus pandemic have spread to all areas of human life, altering the way we interact, paralyzing economies and generating profound changes in societies,” the report said.

Persistently high levels of inequality, the agency said, combined with a sprawling informal labor market that leaves workers without protection and a lack of effective health care coverage have made those problems worse.

Urban slums on the fringes of many of the region’s cities often lack access to basic services, mean many citizens found themselves unable to access food, water and healthcare necessary to confront the crisis.

Poverty meanwhile, has crept upward, while advances in reducing inequality have stagnated, exacerbating trends seen in the five years prior to the crisis.

During that period, Latin America and Caribbean economies grew an average of just 0.3% per year overall, while extreme poverty increased from 7.8% to 11.3% of the population and poverty, from 27.8% to 30.5%.

The report also said the prolonged closure of schools in the region could constitute a “generational catastrophe” that will only deepen inequality.

The pandemic has also brought a rise in mortality that could push down life expectancy in the region depending how long the crisis endures, the agency said.

There have been at least 21,699,000 reported infections and 687,000 reported deaths caused by the novel coronavirus in Latin America and the Caribbean so far.

​ Of every 100 infections last reported around the world, about 24 were reported from countries in Latin America and the Caribbean.

(Reporting by Fabian Cambero; Writing by Dave Sherwood; Editing by Angus MacSwan)

U.S. weekly jobless claims rise moderately; labor market regaining footing

WASHINGTON (Reuters) – The number of Americans filing new claims for unemployment benefits rose last week, likely boosted by brutal winter storms in the densely populated South in mid-February, though the labor market outlook is improving amid declining new COVID-19 cases.

Initial claims for state unemployment benefits totaled a seasonally adjusted 745,000 for the week ended Feb. 27, compared to 736,000 in the prior week, the Labor Department said on Thursday. Economists polled by Reuters had forecast 750,000 applications in the latest week.

Stormy weather in the South left large parts of Texas without power or water for days. The deep freeze shut oil production and refineries in Texas, the biggest producer of natural gas and oil in the United States.

The labor market has lagged the acceleration in overall economic activity, which has been driven by nearly $900 billion in additional pandemic relief provided by the government in late December. Consumer spending rebounded strongly in January as daily coronavirus cases and hospitalizations dropped sharply.

Though the pace of decline in infections has stalled, economists believe the labor market will accelerate in the spring and through summer, noting that vaccinations were increasing daily. A boost to hiring is also expected from President Joe Biden’s $1.9 trillion recovery plan, under consideration by Congress.

Weekly jobless claims have dropped from a record 6.867 million in March 2020 when the pandemic hit the United States a little more than a year ago. They, however, remain above their 665,000 peak during the 2007-09 Great Recession. In a well functioning labor market, claims are normally in a 200,000 to 250,000 range.

Last week’s claims data has no bearing on February’s employment report as it falls outside the period during which the government surveyed establishments and households. According to a Reuters poll of economists, the government will likely report on Friday that nonfarm payrolls increased by 180,000 jobs in February after rising only 49,000 in January.

Hopes for a pick-up in hiring last month were supported by a survey last week showing consumers’ perceptions of the labor market improved in February after deteriorating in January and December. In addition, a measure of manufacturing employment increased to a two-year high in February.

But those expectations were tempered by reports on Wednesday showing private employers hiring fewer-than-expected workers in February. Employment growth in the services industry retreated last month, with businesses reporting they were “unable to fill vacant positions with qualified applicants.”

The year-long COVID-19 pandemic is keeping some workers at home, fearful of accepting or returning to jobs that could expose them to the virus. These workers are now allowed to apply for government-funded unemployment benefits.

The Federal Reserve’s Beige Book report noted “continued difficulties attracting and retaining qualified workers” reported by many of the U.S. central bank’s contacts last month, with labor shortages “most acute among low-skill occupations and skilled trade positions.”

The Fed’s contacts cited the coronavirus, childcare, and unemployment benefits as factors behind the labor supply problem.

(Reporting By Lucia Mutikani; Editing by Chizu Nomiyama)

COVID safety measures still essential even as U.S. boosts vaccine supply: White House

By Carl O’Donnell and Jarrett Renshaw

NEW YORK (Reuters) – U.S. states need to “rally together” to maintain safety measures like social distancing and mask-wearing even as the federal government helps ramp up the production and delivery of vaccines, the White House said on Wednesday.

White House senior adviser Andy Slavitt said the federal government is planning to spend $100 million to help the joint partnership between Merck & Co and rival Johnson & Johnson accelerate vaccine production.

The infusion will help Johnson & Johnson ramp up its production of vaccines, Slavitt said. The company was contracted to deliver 200 million doses to the federal government by the end of May and roughly a billion doses globally by end-2021.

“Over time we believe Merck will be able to double the capacity of Johnson & Johnson,” Slavitt said.

Slavitt said while the increased production is good news, he urged states like Texas to reconsider recent decisions to lift mask mandates and allow businesses to fully open without restrictions.

There are health officials in every state who feel “now is the wrong time to lift the mask mandate,” Slavitt said. “Hopefully, the country will continue to rally together on this front.”

(Reporting By Jarrett Renshaw and Carl O’Donnell; Editing by Sonya Hepinstall)

G20 to show united front on support for global economic recovery, cash for IMF

By Michael Nienaber and Andrea Shalal

BERLIN/WASHINGTON/ROME (Reuters) – The world’s financial leaders are expected on Friday to agree to continue supportive measures for the global economy and look to boost the International Monetary Fund’s resources so it can help poorer countries fight off the effects of the pandemic.

Finance ministers and central bank governors of the world’s top 20 economies, called the G20, held a video-conference on Friday. The global response to the economic havoc wreaked by the coronavirus was at top of the agenda.

In the first comments by a participating policymaker, the European Union’s economics commissioner Paolo Gentiloni said the meeting had been “good,” with consensus on the need for a common effort on global COVID vaccinations.

“Avoid premature withdrawal of supportive fiscal policy” and “progress towards agreement on digital and minimal taxation” he said in a Tweet, signaling other areas of apparent accord.

A news conference by Italy, which holds the annual G20 presidency, is scheduled for 17.15  (1615 GMT).

The meeting comes as the United States is readying $1.9 trillion in fiscal stimulus and the European Union has already put together more than 3 trillion euros ($3.63 trillion) to keep its economies going despite COVID-19 lockdowns.

But despite the large sums, problems with the global rollout of vaccines and the emergence of new variants of the coronavirus mean the future of the recovery remains uncertain.

German Finance Minister Olaf Scholz warned earlier on Friday that recovery was taking longer than expected and it was too early to roll back support.

“Contrary to what had been hoped for, we cannot speak of a full recovery yet. For us in the G20 talks, the central task remains to lead our countries through the severe crisis,” Scholz told reporters ahead of the virtual meeting.

“We must not scale back the support programs too early and too quickly. That’s what I’m also going to campaign for among my G20 colleagues today,” he said.

BIDEN DEBUT

Hopes for constructive discussions at the meeting are high among G20 countries because it is the first since Joe Biden, who vowed to rebuild cooperation in international bodies, became U.S. president.

While the IMF sees the U.S. economy returning to pre-crisis levels at the end of this year, it may take Europe until the middle of 2022 to reach that point.

The recovery is fragile elsewhere too – factory activity in China grew at the slowest pace in five months in January, hit by a wave of domestic coronavirus infections, and in Japan fourth quarter growth slowed from the previous quarter with new lockdowns clouding the outlook.

“The initially hoped-for V-shaped recovery is now increasingly looking rather more like a long U-shaped recovery. That is why the stabilization measures in almost all G20 states have to be maintained in order to continue supporting the economy,” a G20 official said.

But while the richest economies can afford to stimulate an economic recovery by borrowing more on the market, poorer ones would benefit from being able to tap credit lines from the IMF — the global lender of last resort.

To give itself more firepower, the Fund proposed last year to increase its war chest by $500 billion in the IMF’s own currency called the Special Drawing Rights (SDR), but the idea was blocked by then U.S. President Donald Trump.

Scholz said the change of administration in Washington on Jan. 20 improved the prospects for more IMF resources. He pointed to a letter sent by U.S. Treasury Secretary Janet Yellen to G20 colleagues on Thursday, which he described as a positive sign also for efforts to reform global tax rules.

Civil society groups, religious leaders and some Democratic lawmakers in the U.S. Congress have called for a much larger allocation of IMF resources, of $3 trillion, but sources familiar with the matter said they viewed such a large move as unlikely for now.

The G20 may also agree to extend a suspension of debt servicing for poorest countries by another six months.

($1 = 0.8254 euros)

(Reporting by Michael Nienaber in Berlin, Jan Strupczewski in Brussels and Gavin Jones in Rome; Andrea Shalal and David Lawder in Washington; Editing by Daniel Wallis, Susan Fenton and Crispian Balmer)

U.S. urban office market, stung by pandemic, hopes tech firms drive comeback

By Herbert Lash

NEW YORK (Reuters) – The growing footprint in New York of major tech companies like Amazon.com Inc, Facebook Inc and Alphabet Inc’s Google has given property owners and brokers hope that once the coronavirus has been conquered demand for office space will quickly return to pre-pandemic levels.

But the popularity of working from home and the exodus of people from expensive coastal cities will likely weigh on demand and change workspace requirements, leaving office buildings that do not adjust less valuable.

Big Tech’s expanding real estate clout already hides declining values for lower-quality properties.

Prices for premier workspace in U.S. gateway cities have held or even risen during the pandemic in a flight to quality. But leasing volumes and number of buildings sold have plummeted, with valuations at the lower end falling, data shows.

The pandemic has left a massive question mark hanging over the office sector, said Joe Gorin, head of U.S. real estate management and value-added investing at Barings in New York.

“I know how people are going to use the hotel coming out of the pandemic. How are people going to use office buildings?” he asked. “There’s going to be some pain because we’re going to have to go through a restructuring of how people use space.”

Companies need to make the office more compelling and allow busy work to be done at home, which means workspace demand might not grow, Gorin said. Buildings that cannot provide a great environment will become obsolete.

“If you can own or create the right stuff, it’s going to be valuable,” he said. “Office can become more important and shrink as much as it can expand.”

Limited data suggests buildings classified below the top Class A industry designation already have suffered a drop in value during the pandemic and could be poised for a further slide if a decline in demand persists.

The amount of available office space has soared as tech companies have dumped excessive workspace, a sign of uncertainty among management about a company’s future workspace needs.

Institutional investors have put transaction decisions on hold, with the sale of buildings in Manhattan valued at more than $100 million falling more than half to just 32 last year, research by brokerage Newmark Group Inc shows, using Real Capital Analytics data.

Leasing activity has picked up after the New Year but is still far below pre-pandemic levels.

The office sector is the hardest in commercial real estate to assess because leases generally are long-term commitments, said Sam Isaacson, president of Walker & Dunlop Investment Partners in Denver.

“Eventually the cash flow streams have to match up with the asset value appreciation and when that doesn’t occur, that’s when we’re going to see some real pain,” Isaacson said.

WAITING TO MEET THE BOSS

The number of virtual tours brokers conducted with clients fell 61% in December from a year earlier in seven U.S. gateway cities, according to data from View The Space Inc. Tours declined 74% in New York, the biggest drop outside of an 80% plunge in Seattle, the property technology firm said.

A reversal of Seattle’s early recovery from the pandemic may suggest a significant embrace of more remote work in the city over the long-term, VTS said in the report.

“Our data is pointing to the fact tech companies are still really comfortable working from home and they’re probably going to be the last ones to return to the office,” said Ryan Masiello, co-founder and chief strategy officer at VTS.

Of the 115 people VTS has hired since March, Masiello has met none of them because they are all working remotely, he said.

Tech companies led other industries for the second straight year in Manhattan leasing activity, brokerage CBRE Group Inc said in January. A decline in the technology sector’s real estate footprint would be significant for a property market looking to ride the growing digital economy.

Brokers point to Amazon’s $978 million purchase of the Lord & Taylor building on Fifth Avenue last year and Facebook’s leasing of the Farley Building across from Madison Square Garden, as prime examples for Manhattan’s real estate prospects.

The Amazon deal was valued at $1,466 a square foot, more than 10% above last year’s top-quartile average price, while Google’s billion-dollar deals in Chelsea and Hudson Square have redefined swaths of the city’s Far West Side.

Scott Rechler, chief executive and chairman of closely held RXR Realty, one of the largest office building owners in New York, sees a growing disparity between high- and lower-quality properties.

Companies need to re-imagine the workspace and how they engage with employees who expect properties to be well-located, energetic and have health and wellness centers, he said.

“For buildings that can’t do that – they’re not in the right location, they’re older, they’re obsolete – it could be a meaningful free-fall in value,” Rechler said.

(Reporting by Herbert Lash in New York; Editing by Alden Bentley and Matthew Lewis)

U.S. CDC says trend of decline in COVID-19 cases may be stalling

WASHINGTON (Reuters) – The head of the U.S. Centers for Disease Control and Prevention said on Friday that a recent decline in COVID-19 cases may be stalling, a development she described as concerning while urging that restrictions to fight the virus remain in place.

Dr. Rochelle Walensky told reporters the CDC was watching the concerning data closely.

The White House on Friday also urged companies to join efforts to help fight the pandemic by requiring mask wearing by employees and educating customers.

Andy Slavitt, a senior adviser on the White House’s COVID-19 response team, listed a number of companies that were taking measures to help with the pandemic fight and urged more to join.

Ford and the Gap were producing and donating millions of masks, he said, while Best Buy, Target and Dollar General were giving workers paid time off to get vaccines.

The White House is working on a broad campaign to educate Americans about the vaccine as it seeks to bring the pandemic that has killed more than 500,000 people in the United States under control.

President Joe Biden on Thursday noted concerns that later this spring supply of the vaccines would outstrip demand because of vaccine hesitancy.

(Reporting by Jeff Mason, Carl O’Donnell and Lisa Lambert; Editing by Chizu Nomiyama)

Debilitating ‘long-COVID’ may have severe health, social impacts: WHO

By Kate Kelland

LONDON (Reuters) – Thousands of COVID-19 patients continue to suffer serious, debilitating and lingering symptoms many months after their initial bout of infection, with major social, health and economic consequences, European health experts said on Thursday.

Publishing a World Health Organization-led guidance report on the condition, often referred to as “long COVID” or “post-COVID syndrome,” experts said around one in 10 COVID-19 patients are still unwell 12 weeks after their acute infection, and many suffer symptoms for far longer.

“This is a condition that can be extremely debilitating. Those suffering from it describe a varying combination of overlapping symptoms… (including) chest and muscle pain, fatigue, shortness of breath … brain fog (and) many others,” said Martin McKee, a professor at the European Observatory on Health Systems and Policies who led the report.

Hans Kluge, the WHO’s European regional director, said long-COVID could have “severe social, economic, health and occupational consequences.”

“The burden is real and it is significant,” he said.

He urged health authorities to listen to patients’ concerns, take them seriously, and establish services to help them.

Growing evidence from around the world points to many thousands of people experiencing long-COVID. The condition appears not to be linked to whether a patient had a severe or mild infection.

An initial report by Britain’s National Institute for Health Research last year suggested long-COVID may be not one condition, but multiple syndromes causing a rollercoaster of symptoms affecting the body and mind.

Kluge noted that as with any new disease, much remains unknown about COVID-19.

“We need to listen and … understand. The sufferers of post-COVID conditions need to be heard if we are to understand the long-term consequences and recovery from COVID-19,” he said. “This is a clear priority for WHO (and) it should be for every health authority.”

New coronavirus variant identified in New York: researchers

By Deena Beasley

(Reuters) – A new coronavirus variant that shares some similarities with a more transmissible and intractable variant discovered in South Africa is on the rise in New York City, researchers said on Wednesday.

The new variant, known as B.1.526, was first identified in samples collected in New York in November, and by mid-February represented about 12% of cases, researchers at Columbia University Vagelos College of Physicians and Surgeons, said on Wednesday.

The variant was also described in research originally published online February 15 by California Institute of Technology scientists. Neither study has been reviewed by outside experts.

The Columbia researchers said an analysis of publicly available databases did not show a high prevalence of coronavirus variants recently identified in South Africa and Brazil in case samples from New York City and surrounding areas.

“Instead we found high numbers of this home-grown lineage,” Dr. Anne-Catrin Uhlemann, assistant professor in the division of infectious diseases at Columbia University’s College of Physicians and Surgeons, said in a statement.

The Columbia study was designed to search genomes from patient samples for mutations associated with worrisome British, South African and Brazilian virus variants. One mutation, E484K, in a genome region encoding the virus receptor binding domain, has been shown to be an escape mutation that greatly reduces the effectiveness of monoclonal and vaccine-induced antibodies.

Of the 65 virus samples containing the E484K mutation Ho’s team identified, a handful represented cases involving the known concerning variants, but 49 of the 65 belonged to the new New York B.1.526 lineage.

Studies have shown that recently launched coronavirus vaccines are still likely to neutralize the virus and protect against severe illness, even for infections with new variants. Vaccine makers are also working to develop booster shots to combat mutated versions of the virus.