WHO says all hypotheses still open in probe into virus origins

By Reuters Staff

GENEVA (Reuters) – – All hypotheses are still open in the World Health Organization’s search for the origins of COVID-19, WHO Director-General Tedros Adhanom Ghebreyesus told a briefing on Friday.

A WHO-led mission in China said this week that it was not looking further into the question of whether the virus escaped from a lab, which it considered highly unlikely. The United States has said it will review the mission’s findings.

“Some questions have been raised as to whether some hypotheses have been discarded. Having spoken with some members of the team, I wish to confirm that all hypotheses remain open and require further analysis and study,” Tedros said.

“Some of that work may lie outside the remit and scope of this mission. We have always said that this mission would not find all the answers, but it has added important information that takes us closer to understanding the origins of the COVID-19 virus,” he said.

The mission has said its main hypotheses are that the virus originated in a bat, although there are several possible scenarios for how it passed to humans, possibly first by infecting another species of animal.

The former administration of U.S. President Donald Trump said it believed the virus may have escaped from a lab in the Chinese city of Wuhan. China has strongly denied this, and says the Wuhan Institute of Virology was not studying related viruses.

COVID may have taken ‘convoluted path’ to Wuhan, WHO team leader says

By Josh Horwitz and David Stanway

WUHAN, China (Reuters) – The head of a World Health Organization-led team probing the origins of COVID-19 said bats remain a likely source and that transmission of the virus via frozen food is a possibility that warrants further investigation, but he ruled out a lab leak.

Peter Ben Embarek, who led the team of independent experts in its nearly month-long visit to the Chinese city of Wuhan, where the outbreak first emerged at a seafood market in late 2019, said the team’s work had uncovered new information but had not dramatically changed their picture of the outbreak.

“The possible path from whatever original animal species all the way through to the Huanan market could have taken a very long and convoluted path involving also movements across borders,” Embarek told a nearly three-hour media briefing.

Embarek said work to identify the coronavirus’s origins points to a natural reservoir in bats, but it is unlikely that they were in Wuhan.

Investigators were also looking for Chinese blood samples that could indicate that the virus was circulating earlier than first thought, he said.

“In trying to understand the picture of December 2019 we embarked on a very detailed and profound search for other cases that may have been missed, cases earlier on in 2019,” he said.

“And the conclusion was we did not find evidence of large outbreaks that could be related to cases of COVID-19 prior to December 2019 in Wuhan or elsewhere.”

The possibility the virus leaked from a lab – which has been the subject of conspiracy theories – was extremely unlikely and did not require further study, Embarek said.

Liang Wannian, head of China’s expert panel on the outbreak, said there was evidence of coronavirus infections that could have preceded the first detected case by “several weeks”.

“This suggests that we cannot rule out that it was circulating in other regions and the circulation was unreported,” he told the briefing.

FROZEN ANIMALS?

Embarek said the team had identified market vendors selling frozen animal products including farmed wild animals.

“So there is the potential to continue to follow this lead and further look at the supply chain and animals that were supplied to the market,” he said.

China has pushed the idea that the virus can be transmitted by frozen food and has repeatedly announced findings of coronavirus traces on imported food packaging.

“We know the virus can survive in conditions that are found in these cold, frozen environments, but we don’t really understand if the virus can transmit to humans” or under which conditions, Embarek told the briefing.

The team arrived in Wuhan on Jan. 14 and after two weeks of quarantine, visited key sites including the Huanan seafood market, the location of the first known cluster of infections, as well as the Wuhan Institute of Virology, which has been involved in coronavirus research.

Members of the team sought to rein in expectations for the mission, with infectious disease expert Dominic Dwyer saying it would probably take years to fully understand the origins of COVID-19.

The United States said China needed to be more open when it comes to sharing data and samples as well as allowing access to patients, medical staff and lab workers. Beijing subsequently accused Washington of politicizing a scientific mission.

(Reporting by Josh Horwitz in Wuhan and David Stanway in Shanghai; Additional reporting by Stephanie Nebehay in Geneva; Writing by Tony Munroe; Editing by Raju Gopalakrishnan, Gareth Jones and Nick Macfie)

China bat caves need exploring in search for COVID origins, WHO team member says

By David Kirton and David Stanway

WUHAN, China (Reuters) – A member of the World Health Organization-led team searching for clues to the origins of COVID-19 in the central Chinese city of Wuhan said work was needed to try to trace genetic elements of the virus in bat caves.

Peter Daszak, a zoologist and animal disease expert, said the team in Wuhan had been receiving new information about how the virus, first identified in the city in late 2019, led to a pandemic. He did not elaborate but said there was no evidence to suggest it emerged from a lab.

The origin of the coronavirus has become highly politicized following accusations, especially by the United States, that China was not transparent in its early handling of the outbreak. Beijing has pushed the idea that the virus originated elsewhere.

Daszak was involved in research into the origins of Severe Acute Respiratory Syndrome (SARS) in 2002-2003, tracing its roots to bats living in a cave in southwest Yunnan province.

“Similar research needs to be done if we are going to find the true wildlife origin” of COVID-19, said Daszak, president of the New York-based EcoHealth Alliance.

“That sort of work to find the likely bat source is important because if you can find the sources of these lethal viruses you can reduce the contact with those animals,” he told Reuters in an interview.

It is unclear whether China is currently sampling its many bat caves, but viruses similar to SARS-CoV-2 had previously been found in the southwest province of Yunnan.

He said the team in Wuhan had been receiving new information about how the virus led to a pandemic, but did not elaborate.

“I’m seeing a picture coming through of some of the scenarios looking more plausible than before,” he said.

One scenario being scrutinized more closely by the team is the possibility that the virus could have been circulating long before it was first identified in Wuhan.

“That’s something our group is looking at very intensely to see what level of community transmission could have been happening earlier,” Daszak said.

“The real work we are doing here is to trace back from the first cases back to an animal reservoir, and that’s a much more convoluted path, and may have happened over a number of months or even years.”

The investigators have visited hospitals, research facilities and the seafood market where the first outbreak was identified, although their contacts in Wuhan are limited to visits organized by their Chinese hosts.

Daszak said Chinese authorities had not refused any of the team’s requests to visit facilities or meet with key figures.

“It is of course impossible to know what you are not being told, but what I am seeing in China, and what this group is seeing in China, is that what we asked for, we are being allowed to do,” Daszak said.

(Reporting by David Stanway in Shanghai and David Kirton in Wuhan; Editing by Nick Macfie)

WHO team probing COVID-19 visits Wuhan lab, meets ‘Bat Woman’

By Martin Quin Pollard and Thomas Peter

WUHAN, China (Reuters) -A team of investigators led by the World Health Organization visited a virus research laboratory in China’s central city of Wuhan and met with a prominent virologist there in its search for clues to the origins of the COVID-19 pandemic.

The experts spent about 3-1/2 hours at the heavily-guarded Wuhan Institute of Virology, which has been at the center of some conspiracy theories that claim a laboratory leak caused the city’s first coronavirus outbreak at the end of 2019.

“Extremely important meeting today with staff at WIV including Dr. Shi Zhengli. Frank, open discussion. Key questions asked & answered,” team member Peter Daszak said on Twitter.

Shi, a well-known virus hunter who has long focused on bat coronaviruses – earning her the nickname “Bat Woman” – was among the first last year to isolate the novel coronavirus that causes COVID-19.

Most scientists, including Shi, reject the hypothesis of a lab leak. However, some experts speculate that a virus captured from the wild could have figured in lab experiments to test the risks of a human spillover and then escaped via an infected staff member.

“Very interesting. Many questions,” Thea Fischer, a Danish member of the team, called from her car as it sped away from the lab following Wednesday’s visit, in response to a question whether the team had found anything.

Some scientists have called for China to release details of all coronavirus samples studied at the lab, to see which most closely resembles SARS-CoV-2, the virus that causes the respiratory disease.

The WHO, which has sought to manage expectations for the Wuhan mission, has said its members would be limited to visits organized by their Chinese hosts and have no contact with community members, because of health restrictions.

While the novel coronavirus that sparked the pandemic was first identified in Wuhan, Beijing has sought to cast doubt on the notion that it originated in China, pointing to imported frozen food as a possible conduit.

The team will spend two weeks conducting field work after having completed two weeks in hotel quarantine after arrival in Wuhan.

(Reporting by Thomas Peter and Martin Quin in Wuhan; Writing by David Stanway and Tony Munroe; Editing by Clarence Fernandez and Pravin Char)

WHO team in China’s Wuhan visits provincial CDC

WUHAN, China (Reuters) – A World Health Organization-led team investigating the origins of the COVID-19 pandemic on Monday visited the Center for Disease Control and Prevention in China’s central region of Hubei, where the outbreak emerged in late 2019.

The group of independent experts spent about 4-1/2 hours on its longest site visit since completing two weeks of quarantine on Thursday, and did not speak to waiting journalists.

The WHO, which has sought to manage expectations for the mission, has said its members would be limited to visits organized by their Chinese hosts and have no contact with community members, because of health curbs.

The group has so far also visited hospitals where early cases were detected, markets, and an exhibition on the battle with the outbreak in the provincial capital of Wuhan.

No full itinerary for the group’s field work has been announced, and journalists covering the tightly controlled visit have been kept at a distance from team members.

Yanzhong Huang, senior fellow with the Council of Foreign Relations in Washington, said two weeks in the field was not much time for the experts.

“I don’t think they have the time to get any conclusive results. It is more like communication and information exchange,” Huang told Reuters by phone from Washington.

“It depends how diligent they are in digging new information but also about how cooperative and accommodating the Chinese side will be.”

Beijing has sought to cast doubt on the notion that the coronavirus originated in China, pointing to imported frozen food as a conduit.

That hypothesis figured again on Sunday in the Global Times tabloid run by the ruling Communist Party’s People’s Daily.

On Sunday, the experts visited the Huanan seafood market linked to initial infections, and the Baishazhou wholesale food market, where a loudspeaker repeatedly announced that the sale of imported cold chain products was banned at the market.

(Reporting by Martin Quin Pollard and Thomas Peter in Wuhan; Additional reporting by David Stanway in Shanghai; Writing by Tony Munroe; Editing by Gerry Doyle and Clarence Fernandez)

WHO team in Wuhan visits hospital that treated early COVID cases

By Gabriel Crossley

WUHAN, China (Reuters) – A World Health Organization-led team of experts investigating the origins of COVID-19 on Friday visited a hospital in the Chinese city of Wuhan that was one of the first to treat patients in the early days of the outbreak.

The hospital visit was the team’s first in the field after two weeks in quarantine, and a WHO spokeswoman said the group’s contacts in Wuhan will be limited to visits organized by their Chinese hosts due to health restrictions.

“The team will go out but they will be bussed to wherever, so they won’t have any contact with the community. They will only have contact with various individuals that are being organized as part of the study,” WHO spokeswoman Margaret Harris told a briefing in Geneva on Friday.

After meeting with Chinese scientists earlier in the day, the team went to the Hubei Provincial Hospital of Integrated Chinese and Western Medicine.

Zhang Jixian, director of the hospital’s department of respiratory and critical care, has been cited by state media as the first to report the novel coronavirus, after treating an elderly couple in late 2019 whose CT scans showed differences from typical pneumonia.

“Extremely important 1st site visit. We are in the hospital that treated some of the first known cases of COVID-19, meeting with the actual clinicians & staff who did this work, having open discussion about the details of their work,” Peter Daszak, a member of the WHO-led team, wrote on Twitter.

The team plans to visit labs, markets and hospitals during its remaining two weeks in Wuhan, where the coronavirus was first identified in late 2019.

While an exact itinerary has not been announced, the WHO has said the team plans to visit the seafood market at the center of the early outbreak as well as the Wuhan Institute of Virology. One hypothesis, rejected by China, is that the outbreak was caused by a leak at the government lab.

The WHO-led probe in Wuhan has been plagued by delays, concern over access and bickering between China and the United States, which accused China of hiding the extent of the initial outbreak and criticized the terms of the visit, under which Chinese experts conducted the first phase of research.

The WHO has sought to manage expectations. “There are no guarantees of answers,” its emergency chief, Mike Ryan, said this month.

The investigating team had been set to arrive in Wuhan earlier in January, and China’s delay of their visit drew rare public criticism from the head of the WHO, which former U.S. President Donald Trump accused of being “China-centric”.

A Chinese foreign ministry spokesman, Zhao Lijian, said on Friday that WHO and Chinese experts were working together to trace the origin of the virus, but stressed that the mission was not a probe.

“It is part of a global research, not an investigation,” Zhao told a regular news conference in Beijing.

China has pushed the idea that the virus existed abroad before it was discovered in Wuhan, with state media citing the presence of the virus on imported frozen food packaging and scientific papers saying it had been circulating in Europe in 2019.

China’s foreign ministry has also hinted that the sudden closure of a U.S. army laboratory at Fort Detrick in Maryland in July 2019 was linked to the pandemic.

“At the early stage in China, it was a burden particularly for Wuhan people when everyone was calling it a Wuhan virus, which was humiliating,” said Yang You, a 30-year-old Wuhan resident. “If it could be traced to the source clearly, in my opinion, it could clear either China’s or Wuhan’s name.”

(Reporting by Gabriel Crossley and Martin Quin Pollard; Additional reporting by Yew Lun Tian in Beijing and Stepahnie Nebehay in Geneva; Writing by Tony Munroe; Editing by Michael Perry, Nick Macfie & Simon Cameron-Moore)

WHO team in Wuhan probing COVID-19 origins moves out of quarantine

By Gabriel Crossley

WUHAN, China (Reuters) – A World Health Organization-led team investigating the origins of the COVID-19 pandemic left its quarantine hotel in Wuhan on Thursday to begin field work, two weeks after arriving in the Chinese city where the virus emerged in late 2019.

The mission has been plagued by delays, concern over access and bickering between China and the United States, which has accused China of hiding the extent of the initial outbreak and criticized the terms of the visit, under which Chinese experts conducted the first phase of research.

“Thanks, Chinese Health Minister Ma Xiaowei, for a frank discussion on the #COVID19 virus origins mission,” WHO Director-General Tedros Adhanom Ghebreyesus tweeted.

“I asked that the international scientists get the support, access & data needed, and the chance to engage fully with their Chinese counterparts.”

The WHO has not provided details of the mission’s itinerary, although team leader Peter Ben Embarek said in November that the group would likely go to the Huanan Seafood Wholesale Market, where the first known cluster of cases was traced.

The team, made up of independent experts, is due to remain for two more weeks in China, which has used stringent measures, including drastically curtailing international arrivals, to curb the spread of the coronavirus. China has been battling a series of local outbreaks over the past month.

“During the second 14 days, the team will be able to go out under strict medical supervision, continuous testing and the restrictive measures,” Hans Kluge, the WHO’s European regional director, told a news conference from Copenhagen on Thursday.

He said the first two weeks had been productive.

“The team members have been prepared by counterparts in China in different fields, there have been, every day, many, many hours of presentations and exchange of data,” he said.

After leaving their quarantine hotel shortly after 3 p.m. (0700 GMT) without speaking to journalists, team members boarded a bus to a lakeside hotel, where a portion of the building and grounds were cordoned off.

Several team members described long work days during their quarantine, and relief at being able to leave their rooms.

“Slightly sad to say goodbye to my ‘gym’ & my ‘office’ where I’ve been holed up for last 2 wks!!,” team member Peter Daszak said on Twitter, along with photos of exercise equipment and a desk in his hotel room.

The team members’ luggage, loaded onto the bus by workers in protective suits, included yoga mats and what appeared to be a guitar case.

SCIENCE AND POLITICS

The WHO has sought to manage expectations for the investigation.

“There are no guarantees of answers,” WHO emergencies chief Mike Ryan told reporters this month. “It is a difficult task to fully establish the origins and sometimes it can take two or three or four attempts to be able to do that in different settings.”

China’s foreign ministry said the team would participate in seminars, visits and field trips.

“All these activities must be in accordance with the principle of tracking the origin scientifically and with the ultimate goal of preventing future risks and protecting the safety and health of the people,” ministry spokesman Zhao Lijian told a regular briefing on Thursday.

The origin of COVID-19 has been highly politicized.

The investigating team had been set to arrive in Wuhan earlier in January, and China’s delay of their visit drew rare public criticism from the head of the WHO, which former U.S. President Donald Trump accused of being “China-centric” early in the outbreak.

China has been pushing a narrative that the virus existed abroad before it was discovered in Wuhan, with state media citing the presence of the virus on imported frozen food packaging and scientific papers saying it had been circulating in Europe in 2019.

China’s foreign ministry has also hinted on several occasions that the sudden closure of a U.S. army laboratory at Fort Detrick in Maryland in July 2019 was linked to the pandemic.

Wuhan resident Tu Zhengwang, 28, said it was not certain that the virus had originated in the city.

“It could be other places,” he said. “But if you find the origin, whether it is in Wuhan or other places, you could prevent similar incidents from happening.”

(Reporting by Gabriel Crossley in Wuhan; Additional reporting by Yew Lun Tian in Beijing and Stephanie Nebehay in Geneva; Writing by Tony Munroe; Editing by Simon Cameron-Moore, Raju Gopalakrishnan and Alex Richardson)

Africa secures 400 million more COVID-19 vaccine doses

By George Obulutsa

NAIROBI (Reuters) – The African Union (AU) has secured another 400 million doses of the AstraZeneca COVID-19 vaccine, a regional health leader said on Thursday, in a push to immunize 60% of the continent’s population over three years.

As richer nations race ahead with mass immunization campaigns, Africa is scrambling to obtain supplies for its 1.3 billion people. Only a handful of African nations have begun giving doses.

John Nkengasong, director of the AU’s disease control and prevention body, told an online briefing that in addition to 270 million doses previously secured, the bloc would get 400 million shots from the Serum Institute of India (SII) – all AstraZeneca/Oxford University shots.

A spokesman for the SII declined comment.

The AstraZeneca vaccine is the cheapest option and one of the best-suited to African health systems as it does not require storage at ultra-low temperatures like the vaccine from Pfizer and German partner BioNTech.

Separately from the AU’s efforts, Africa is to receive about 600 million vaccine doses this year via the COVAX facility co-led by the World Health Organization (WHO).

Health authorities hope to vaccinate about 30-35% of Africans this year, rising to 60% in two to three years. The AU has said vaccines secured by its vaccine task team will be allocated according to population.

Though COVID-19 has not hit Africa as badly as some experts had feared it would, wealth disparities, logistical difficulties and “vaccine nationalism” by developed nations may put the world’s poorest continent at a disadvantage.

Africa has reported 3.5 million infections and 88,000 deaths, according to a Reuters tally. That is fewer fatalities than individual nations the United States, Brazil, India, Mexico and Britain.

OUTLIER TANZANIA

In an implicit rebuke to Tanzanian President John Magufuli, who has discouraged mask-wearing and social distancing, discontinued data publication and called vaccines a malign foreign plot, WHO Africa director Matshidiso Moeti urged Tanzania to implement such measures, prepare vaccinations and share data. “Africa is at a crossroads and all Africans must double down on preventive measures,” she told an online news conference on Thursday, saying WHO officials were in touch with Tanzanian officials. “Science shows that vaccines work.”

Magufuli’s government has published no coronavirus data since May 8, when the country had 509 cases and 21 deaths.

On Wednesday, he said, without evidence, that vaccines were a foreign plot to spread illness and steal Africa’s wealth. He urged Tanzanians instead to trust God and use alternative remedies such as steam inhalation.

“We in Tanzania managed to stay for a year without corona. Even here, no one has put on a mask. Our God is beyond Satan and Satan will always fail using different diseases,” he said in a speech in his western home area.

Nkengasong said the Africa CDC was exploring obtaining more vaccines from China, Russia and Cuba, and would work with any partner whose vaccine was safe and effective.

(Reporting by George Obulutsa, Nairobi newsroom and Alexander Winning; Writing by Andrew Cawthorne; Editing by Alex Richardson and Frances Kerry)

WHO issues new clinical advice on treating COVID-19 patients

GENEVA (Reuters) – The World Health Organization (WHO) issued fresh clinical advice on Tuesday for treating COVID-19 patients, including those displaying persistent symptoms after recovery, and also said it advised using low-dose anti-coagulants to prevent blood clots.

“The other things in the guidance that are new are that COVID-19 patients at home should have the use of pulse oximetry, that’s measuring the oxygen levels, so you can identify whether someone at home is deteriorating and would be better off having hospital care,” WHO spokeswoman Margaret Harris told a U.N. briefing in Geneva.

The WHO advised clinicians to put patients into the awake prone position, on their front, shown to improve the oxygen flow, she said.

“Also we recommend, we suggest, the use of low-dose anti-coagulants to prevent blood clots forming in blood vessels. We suggest the use of lower doses rather than higher doses because higher doses may lead to other problems,” Harris said.

She added that a WHO-led team of independent experts, currently in the central Chinese city of Wuhan where the first human cases were detected in December 2019, is due to leave quarantine in the next two days to pursue its work with Chinese researchers on the virus origins.

She declined to comment on reports of delays in roll-out of vaccines in the European Union. She said she had no specific data and the WHO’s priority was for health workers in all countries to be vaccinated in the first 100 days of the year.

AstraZeneca, which developed its shot with Oxford University, told the EU on Friday it could not meet agreed supply targets up to the end of March.

(Reporting by Stephanie Nebehay and Emma Farge)

Biden to hit reset on nation’s fight against COVID-19 on his first day as president

By Susan Heavey and Patricia Zengerle

WASHINGTON (Reuters) – President Joe Biden on Wednesday will immediately reset the nation’s response to the COVID-19 crisis when he heads to the Oval Office after being sworn in to lead a country reeling from its worst public health crisis in more than a century.

As part of a first sweep of executive actions, Biden will order that all federal employees wear masks and make face coverings mandatory on federal property. He will establish a new White House office to coordinate the coronavirus response and halt the withdrawal of the United States from the World Health Organization, a process initiated by former President Donald Trump.

Biden was also poised to nominate an acting U.S. surgeon general as soon as Wednesday, a person familiar with the decision told MSNBC, following the resignation of Trump appointee Jerome Adams.

Biden’s executive actions, particularly the mask mandate, are intended to set an example for state and local officials to rein in the virus, which has hobbled the U.S. economy. The United States has reported nearly 200,000 new COVID-19 cases and 3,000 deaths per day on a seven-day rolling average, according to Reuters data. More than 123,000 Americans were hospitalized with COVID-19 as of Wednesday.

Scientists and public health experts have said face masks can help prevent the spread of the highly contagious novel coronavirus, but the coverings have become a flashpoint in American life reflecting the nation’s larger political divide.

(Reporting by Susan Heavey, Patricia Zengerle and Trevor Hunnicutt in Washington, Anurag Maan in Bengaluru, Gabriella Borter in Florida; Editing by Lisa Shumaker)