Tag Archives: diphtheria

Delta variant doubles risk of hospitalization; Novavax vaccine highly effective in large trial

By Nancy Lapid

(Reuters) – The following is a roundup of some of the latest scientific studies on the novel coronavirus and efforts to find treatments and vaccines for COVID-19, the illness caused by the virus.

Delta variant doubles risk of COVID-19 hospitalization

The delta variant of the coronavirus first identified in India may double the risk of hospitalization among COVID-19 patients, compared with the alpha variant first discovered in the UK, a study from Scotland suggests. Researchers looked at 19,543 COVID-19 cases and 377 hospitalizations among 5.4 million people, including 7,723 cases and 134 hospitalizations in patients with the delta variant, who tended to be younger and more affluent. The risk of COVID-19 hospital admission was about double with the delta variant compared to the alpha variant, with the risk particularly increased in those with five or more medical conditions known to contribute to more severe disease, the researchers reported on Monday in The Lancet. They found that two doses of the vaccines from Pfizer and BioNTech and from AstraZeneca still provide strong protection, although not as strong as the protection provided against the alpha variant. Two weeks after the second dose, the Pfizer/BioNTech vaccine was found to provide 79% protection against infection from the delta variant, compared to 92% against the alpha variant. With AstraZeneca’s vaccine, there was 60% protection against delta compared with 73% for alpha. Because this was an observational study, more research is needed to confirm the findings, the research team said.

Novavax vaccine highly effective in North American trial

Novavax Inc on Monday said its COVID-19 vaccine was more than 90% effective, including against a variety of concerning coronavirus variants, in a large, late-stage clinical trial, providing another potential weapon against the disease once approved for use. In the trial involving nearly 30,000 volunteers in the United States and Mexico, the two-shot vaccine was 100% effective in preventing infection by the original version of the coronavirus, the company said. It was more than 93% effective against the predominant variants of the virus that have been of concern among scientists and public health officials. The alpha variant first identified in the UK was the predominant variant in the United States while the trial was being conducted, the company said. The vaccine was 91% effective among volunteers at high risk of severe infection and 100% effective in preventing moderate and severe cases of COVID-19. Novavax said the vaccine was generally well tolerated, with side effects similar to those seen with existing COVID-19 vaccines. The Novavax COVID-19 shot is a more conventional type of vaccine than those currently available. It contains an actual version of the virus’ spike protein that cannot cause disease but can trigger the immune system directly. The company said the results put it on track to file for emergency authorization in the United States and elsewhere in the third quarter of 2021.

Tetanus, diphtheria boosters tied to less severe COVID-19

Older individuals who have gotten a diphtheria or tetanus vaccine booster shot in the last 10 years may be at lower risk for severe COVID-19, a new study suggests. Using a large UK registry, researchers looked back at 10 years of immunization records from 103,409 participants with an average age of 71. They saw a trend toward a lower risk of a positive COVID-19 test in people who had gotten a tetanus or diphtheria booster shot during the study period, although the difference was small and might have been due to chance. There was, however, a statistically significant association between the booster shots and the odds of severe COVID-19. After accounting for age, sex, underlying respiratory diseases, and socioeconomic status, the odds of developing severe COVID-19 were 64% lower in people who had gotten a diphtheria booster and 50% lower in recipients of tetanus booster, according to a report posted on medRxiv on Saturday ahead of peer review. The study does not prove cause and effect. If there is some effect of the boosters, it might be that they protect against severe COVID-19 symptoms by stimulating the immune system, the authors suggest. “The possibility that these vaccinations may influence the severity of COVID-19 warrants follow-up investigations,” they conclude.

(Reporting by Nancy Lapid, Carl O’Donnell and Alistair Smout; Editing by Bill Berkrot)

Yemen’s cholera epidemic likely to intensify in coming months: WHO

FILE PHOTO: A nurse walks by women being treated at a cholera treatment center in the Red Sea port city of Hodeidah, Yemen October 8, 2017. REUTERS/Abduljabbar Zeyad

RIYADH (Reuters) – The World Health Organization warned on Monday that a cholera epidemic in Yemen that killed more than 2,000 people could flare up again in the rainy season.

WHO Deputy Director General for Emergency Preparedness and Response Peter Salama said the number of cholera infections had been in decline in Yemen over the past 20 weeks after it hit the 1 million mark of suspected cases.

“However, the real problem is we’re entering another phase of rainy seasons,” Salama told Reuters on the sidelines of an international aid conference in Riyadh.

“Usually cholera cases increase corresponding to those rainy seasons. So we expect one surge in April, and another potential surge in August.”

A proxy war between Iran-aligned Houthis and the internationally recognized government of President Abd-Rabbu Mansour Hadi, which is backed by a Saudi-led alliance, has killed more than 10,000 people since 2015, displaced more than 2 million and destroyed much of the country’s infrastructure, including the health system.

Yemen relies heavily on food imports and is on the brink of famine. The United Nations says more than 22 million of Yemen’s 25 million population need humanitarian assistance, including 11.3 million who are in acute need.

Salama said the country had also had an outbreak of diphtheria, a vaccine-preventable disease that usually affects children and which has largely been eliminated in developed countries.

Both cholera and diphtheria outbreaks are a product of the damage to the health system in the country, he said, adding that less than half of Yemen’s health facilities are fully functioning.

“We’re very concerned we’re going to go from a failing health system to a failed one that’s going to spawn more infectious diseases and more suffering,” Salama said.

However, Salama said that despite more than 2,000 deaths from cholera, the fatality rate has been low, at around 0.2 to 0.3 percent.

The WHO has approval from the government for vaccination campaigns and is working on ensuring all parties to the conflict implement the plan, he added.

(Reporting by Sarah Dadouch; Editing by Alison Williams)

United Nations hopes imports will help stave off famine in Yemen as diphtheria spreads

A nurse holds a premature baby in an incubator at the child care unit of a hospital in Sanaa, Yemen January 16, 2018.

By Stephanie Nebehay

GENEVA (Reuters) – United Nations aid agencies called on Tuesday for the Yemeni port of Hodeidah to remain open beyond Friday, the date set by a Saudi-led military coalition, to permit continued delivery of life-saving goods.

Yemen is the world’s worst humanitarian crisis, where 8.3 million people are entirely dependent on external food aid and 400,000 children suffer from severe acute malnutrition, a potentially lethal condition, they said.

The Arab coalition, under international pressure, eased a three-week blockade which was imposed on Yemeni ports and airports in November in response to a ballistic missile fired by the Houthi movement toward the Saudi capital Riyadh.

Four mobile cranes arrived in the important Houthi-controlled Hodeidah port, the U.N. said on Monday, after the coalition agreed to let them into Yemen, where nearly three years of war have pushed it to the verge of famine.

“The port in theory is going be open to the 19th of this month. Then we don’t know if the coalition will close or (leave) it open,” Meritxell Relano, U.N. Children’s Fund (UNICEF) Representative in Yemen, told a news briefing in Geneva.

“Obviously the feeling is that they extend this period so that the commercial goods can come in, but especially the fuel,” she said, speaking from the capital Sanaa.

Before the conflict, Hodeidah port handled around 70 percent of Yemen’s imports, including food and humanitarian supplies.

Fuel is vital to power water and sanitation stations to provide clean water and help avoid diseases, she said.

More than 11 million Yemeni children – virtually all – need humanitarian assistance, Relano said. UNICEF figures show 25,000 Yemeni babies die at birth or before the age of one month.

A child lies in a bed at a hospital in Sanaa, Yemen January 16, 2018

A child lies in a bed at a hospital in Sanaa, Yemen January 16, 2018. REUTERS/Khaled Abdullah

“Yemen is in the grips of the world’s biggest hunger crisis,” World Food Programme (WFP) spokeswoman Bettina Luescher said. “This is a nightmare that is happening right now.”

“We appeal to parties on (the) ground in order to stave off famine that we can continue regularly to get food in, to get medicines in, to get fuel in, be it from the humanitarian or the commercial side,” she said.

Luescher, asked about prospects for the Hodeidah port lifeline to remain open, replied: “Obviously since the cranes were imported and are operational, we are hopeful and optimistic that our work can continue.”

A diphtheria outbreak in Yemen is “spreading quickly”, with 678 cases and 48 associated deaths in four months, Fadela Chaib of the World Health Organisation said.

The number of cases has doubled since Dec 22, when the WHO reported 333 people affected by the highly-contagious disease, with 35 deaths. Ibb and Hodeidah are the worst-hit of the 19 affected governorates, Chaib said.

“We can stop the outbreak by providing antibiotics and also vaccinating,” she said. Some 2.5 million doses have been imported for a planned immunization campaign, she said.

(Reporting by Stephanie Nebehay; Editing by Larry King, William Maclean)

Yemen set to run out of fuel and vaccine in a month: UNICEF

A boy is being treated at a malnutrition treatment center in Sanaa, Yemen November 4, 2017.

GENEVA (Reuters) – Yemen’s stocks of fuel and vaccines will run out in a month unless a Saudi-led military coalition allows aid into the blockaded port of Hodeidah and Sanaa airport, UNICEF’s representative in the country said on Friday.

Meritxell Relano, speaking by phone to reporters in Geneva, said fuel prices had risen 60 percent and there were urgent concerns about a diphtheria outbreak, as well as food shortages because of the port closure.

“The situation that was already catastrophic is just getting worse,” she said. “The impact of this is unimaginable in terms of health and diseases.”

After two years of civil war, Yemen has 7 million people on the brink of famine and has had 900,000 suspected cholera cases in the past six months.

The number of new cases has fallen consistently for the past eight weeks, according to data from the World Health Organization.

But progress against cholera, which has killed 2,196 people, could be reversed by the blockade, WHO spokeswoman Fadela Chaib told a regular U.N. briefing in Geneva.

“If the closure is not stopped in the coming days, we may see that the progress is stopped,” Chaib said. “We can see even more cases and more deaths as a result of not being able to get access to people.”

The closure of Hodeidah port prevented a ship setting sail from Djibouti with 250 tonnes of WHO medical supplies on Wednesday. Trauma kits in particular are running short.

“If the hostilities continue and the ports remain closed, we will not be able to perform life-saving surgeries or provide basic healthcare,” Chaib said.

 

(Reporting by Tom Miles; Editing by Andrew Roche)