In U.S. Midwest states, new COVID-19 infections rise to record highs

By Lisa Shumaker and Maria Caspani

CHICAGO (Reuters) – Wisconsin and other states in the U.S. Midwest are battling a surge in COVID-19 cases, with new infections and hospitalizations rising to record levels in an ominous sign of a nationwide resurgence as temperatures get colder.

More than 22,000 new cases of the novel coronavirus were reported on Wednesday across the Midwest, compared with a previous record of more than 20,000 on Oct. 9. Hospitalizations in those states reached a record high for a 10th day in a row as some hospitals began feeling the strain.

More than 86% of the beds in Wisconsin’s intensive care units were in use as of Wednesday, and a field hospital opened in a Milwaukee suburb in case medical facilities become overwhelmed.

Neat rows of makeshift cubicles enclosing beds and medical supplies occupied the fairgrounds in West Allis, which has been the home of the Wisconsin State Fair since the late 1800s.

Dr. Paul Casey, the medical director of the emergency department at Bellin Hospital in Green Bay, Wisconsin said entire wards full of COVID-19 patients were stretching resources “to the limit.”

“It’s going to get worse,” he told CNN on Thursday. “We predict it will peak mid-Novemeber.”

More than 1,000 people were hospitalized for COVID-19 in Wisconsin on Wednesday, the state’s health department said, and health authorities recorded an almost 25% spike in coronavirus hospitalizations in the past seven days compared to the previous week.

Other Midwestern states were also setting grim records.

Since the start of October, North Dakota and South Dakota have reported more new COVID-19 cases per capita than all but one country in the world, Andorra.

These states are reporting three times as many new cases per capita this month than the United Kingdom, Spain or France, according to a Reuters analysis.

“It’s quite concerning,” Dr. Anthony Fauci, the nation’s top infectious disease expert, said in an interview with ABC television on Thursday. “We really got to double down on the fundamental public health measures that we talk about every single day because they can make a difference.”

Fauci also warned about the risks of holding crowded rallies as President Donald Trump returned to the campaign trail after recovering from the coronavirus.

Trump, making a push in the weeks before the Nov. 3 presidential election after being hospitalized with COVID-19, has continued to minimize the threat to public health posed by the virus that has killed more than 216,000 Americans.

New York, once the U.S. epicenter of the virus, is now dealing with a spike in infections in several “clusters.” Governor Andrew Cuomo said he expected flare-ups to continue for at least a year.

“The way of the world going forward is going to be that the virus will constantly flare up in certain locations,” Cuomo told reporters on Wednesday. “The art form is going to be identify these small sites where it flares up and be able to stop it before it spreads.”

(Reporting by Lisa Shumaker in Chicago and Maria Caspani in New York; Additional reporting by Gabriella Borter in New York; Editing by David Gregorio)

U.S. CDC reports 215,194 deaths from coronavirus

(Reuters) – The U.S. Centers for Disease Control and Prevention (CDC) on Wednesday reported 7.8 million cases of the new coronavirus, an increase of 47,459 from its previous count, and said the number of deaths had risen by 748 to 215,194.

The CDC reported its tally of cases of the respiratory illness known as COVID-19, caused by the new coronavirus, as of 4 pm ET on Oct. 13 versus its previous report a day earlier.

The CDC figures do not necessarily reflect cases reported by individual states.

(Reporting by Vishwadha Chander in Bengaluru; Editing by Anil D’Silva)

Countries turn to rapid antigen tests to contain second wave of COVID-19

By John Miller, Caroline Copley and Bart H. Meijer

ZURICH/BERLIN (Reuters) – Countries straining to contain a second wave of COVID-19 are turning to faster, cheaper but less accurate tests to avoid the delays and shortages that have plagued efforts to diagnose and trace those infected quickly.

Germany, where infections jumped by 4,122 on Tuesday to 329,453 total, has secured 9 million so-called antigen tests per month that can deliver a result in minutes and cost about 5 euros ($5.90) each. That would, in theory, cover more than 10% of the population.

The United States and Canada are also buying millions of tests, as is Italy, whose recent tender for 5 million tests attracted offers from 35 companies. Switzerland, where new COVID-19 cases are at record levels, is considering adding the tests to its nationwide screening strategy.

Germany’s Robert Koch Institute (RKI) now recommends antigen tests to complement existing molecular PCR tests, which have become the standard for assessing active infections but which have also suffered shortages as the pandemic overwhelmed laboratories and outstripped manufacturers’ production capacity.

PCR tests detect genetic material in the virus while antigen tests detect proteins on the virus’s surface, though both are meant to pick up active infections. Another type of test, for antibodies the body produces in response to an infection, can help tell if somebody has had COVID-19 in the past.

Like PCR (polymerase chain reaction) tests, antigen tests require an uncomfortable nasal swab. They can also produce more “false negatives,” prompting some experts to recommend they only be used in a pinch.

Still, the alarming rise in new infections globally has health officials desperately pursuing more options as the winter influenza season looms.

The World Health Organization reported more than 2 million new cases last week, bringing the total worldwide to 37 million, with more than 1 million deaths from COVID-19.

“These point-of-care tests could make a big difference,” said Gerard Krause, epidemiology department director at Germany’s Helmholtz Centre for Infection Research.

NO TEST NO FLIGHT

Krause said low-priority patients – those without symptoms – could initially be screened with antigen tests, leaving the more accurate PCR tests for those showing signs of the disease.

Antigen tests have already gained traction in the travel industry. Italian airline Alitalia offers Rome-Milan flights exclusively for passengers with negative tests and Germany’s Lufthansa has announced similar testing plans.

But the pandemic’s vast scale has strained the ability of countries to test all of their citizens, making it difficult to track the twisting paths of infection comprehensively and prevent a resurgence.

In the United States, for example, reliance on automated PCR machinery over the summer left many patients frustrated as they waited for a week or more for results.

Testing in Europe has also suffered glitches.

France does over a million tests a week but its free-for-all testing policy has led to long queues and delays in results, prompting French researchers to come up with a test they say can produce results in 40 minutes, without using a swab.

Italy does between 800,000 and 840,000 tests a week, more than double April’s levels, according to the Ministry of Health. But a government adviser, University of Padua microbiology professor Andrea Crisanti, said the country needs 2 million tests a week to really get on top of the virus.

In the Netherlands, where infection rates are among Europe’s highest, the government has been scrambling to expand weekly testing and lab capacity to 385,000 by next week from 280,000 now. The target is nearly half a million tests a week by December and just under 600,000 by February.

But people have been waiting days for a test. The authorities blame the overwhelming demand from those without clear symptoms for clogging up the system.

In response, the authorities have restricted rapid antigen tests to health workers and teachers, while others go on a waiting list.

‘GOLD STANDARD’

The various hitches highlight a conundrum for governments: how to get people back to work while tracing the virus within the population quickly – without running out of supplies.

Siemens Healthineers, which on Wednesday announced the launch of a rapid antigen test kit in Europe that can deliver a result in 15 minutes, said the volumes of such diagnostic tests being circulated globally now are “at the limits” of what manufacturers can supply.

Rivals including Abbott Laboratories and Becton Dickinson also offer numerous COVID-19 diagnostic tests, with more and more companies jumping in.

Swiss diagnostics maker Roche, announced plans on Tuesday to launch a new antigen test by the end of the year. Its fully automated systems can provide a test result in 18 minutes and a single lab machine can process 300 tests an hour.

By early 2021, the Basel-based company said it could make some 50 million of the new tests a month, on top of the rapid point-of-care tests it already sells.

Roche said the test could be deployed in places such as nursing homes or hospitals, where speedy results could thwart a potentially lethal outbreak.

“The primary use case is the testing of symptomatic patients,” a Roche spokeswoman said. “The secondary use case is the testing of individuals suspected of infection … which could also include asymptomatic patients.”

Expert opinion, however, on just how to use antigen tests is evolving and remains the subject of debate.

Switzerland, where reported new infections spiked to 2,823 cases on Wednesday from as low as three per day in June, is only now validating the accuracy of the rapid tests.

“Deployment of the rapid tests – where it makes sense – will be integrated into our testing strategy,” a spokesman for the Swiss federal health ministry said. “We’ll update our testing recommendations in November.”

Sandra Ciesek, director of the Institute of Medical Virology at the University Clinic in Frankfurt, Germany said rapid antigen tests could be an option for asymptomatic patients planning to visit elderly patients at nursing homes.

But people should refrain from using them as a definitive substitute to judge their infection status.

“The PCR test remains the gold standard,” Ciesek said. “An antigen test should only be used as an alternative if PCR is not possible in a timely manner.”

(Reporting by John Miller in Zurich, Caroline Copley in Berlin, Emilio Parodi and Giselda Vagnoni in Milan, Josephine Mason in London, Bart Meijer in Amsterdam and Matthias Blamont in Paris; Editing by David Clarke)

U.S. CDC reports 214,446 deaths from coronavirus

(Reuters) – The U.S. Centers for Disease Control and Prevention (CDC) on Tuesday reported 7,787,548 cases of the new coronavirus, an increase of 46,614 from its previous count, and said that the number of deaths had risen by 338 to 214,446.

The CDC reported its tally of cases of the respiratory illness known as COVID-19, caused by a new coronavirus, as of 4 pm ET on Oct. 12 versus its previous report a day earlier.

The CDC figures do not necessarily reflect cases reported by individual states.

(Reporting by Dania Nadeem in Bengaluru; Editing by Devika Syamnath)

New U.S. COVID-19 cases rise 11% last week, Midwest hard hit

(Reuters) – The number of new COVID-19 cases rose 11% in the United States last week compared to the previous seven days, with infections spreading rapidly in the Midwest, which reported some of the highest positive test rates, according to a Reuters analysis.

Deaths fell 3% to about 4,800 people for the week ended Oct. 11, according to the analysis of state and county reports. Since the pandemic started, nearly 215,000 people have died in the United States and over 7.7 million have become infected with the novel coronavirus.

Twenty-nine out of 50 states have seen cases rise for at least two weeks in a row, up from 21 states in the prior week. They include the entire Midwest except Illinois and Missouri, as well as new hot spots in the Northeast, South and West.

In Idaho, 23.5% of more than 17,000 tests came back positive for COVID-19 last week, the highest positive test rate in the country, according to data from The COVID Tracking Project, a volunteer-run effort to track the outbreak. South Dakota, Iowa and Wisconsin also reported positive test rates above 20% last week.

For a third week in a row, testing set a record high in the country, with on average 976,000 tests conducted each day last week. The percentage of tests that came back positive for the virus rose to 5.0% from 4.6% the prior week.

The World Health Organization considers rates above 5% concerning because it suggests there are more cases in the community that have not yet been uncovered.

(Writing by Lisa Shumaker; Graphic by Chris Canipe; Editing by Tiffany Wu)

COVID-19 antibodies last at least three months; so do symptoms for many

By Nancy Lapid

(Reuters) – The following is a roundup of some of the latest scientific studies on the novel coronavirus and efforts to find treatments and vaccines for COVID-19, the illness caused by the virus.

COVID-19 antibodies last at least three months

People infected with COVID-19 develop antibodies targeting the new coronavirus that last for at least three months, according to two reports published on Thursday in Science Immunology. The two studies, together involving nearly 750 patients, both point to immunoglobulin G (IgG) antibodies, which start showing up well after an infection begins, as the longest-lasting. Researchers found IgG antibodies with two targets – a spike protein on the virus that helps it infect cells, and a part of the spike called the receptor binding domain (RBD) – lasted more than 100 days. While the protective effect of COVID-19 antibodies is not completely clear, Jen Gommerman of the University of Toronto, coauthor of the study, said her team also found levels of so-called neutralizing antibodies, which inactivate the virus, “appeared to be very stable.” The other study, from Harvard Medical School, reported similar findings. This means that a properly designed vaccine “should elicit a durable antibody response that has the potential to neutralize the virus,” Gommerman said. Her group also found that antibodies in saliva correlated with antibodies in blood, but at this point the saliva tests are not sensitive enough to replace blood tests.

COVID-19 symptoms linger for months for many

Three months after becoming ill, many COVID-19 patients still have symptoms, two studies confirm, and the more severe the initial infections, the higher the odds of persistent problems. In Spain, doctors checked back with 108 patients, including 44 who had been severely ill. At 12 weeks after diagnosis, 76% still reported after-effects, with 40% reporting three or more coronavirus-related health issues, doctors said in a paper posted on Thursday on medRxiv ahead of peer review. The most common complaints were shortness of breath, physical weakness, cough, chest pain, palpitations, and psychological and cognitive disorders. In a similar study of 233 U.S. COVID-19 patients – eight of whom had been severely ill – one in four still had symptoms 90 days after first feeling ill. Rates were higher for patients who had been sicker: 59.4% at 30 days and 40.6% at 90 days. “But even for very mild and initially asymptomatic cases, 14.3% have complications persist for 30 days or longer,” the authors reported on Sunday on medRxiv. In the U.S. study, the most common persistent symptoms were impaired smell and taste, difficulty concentrating, shortness of breath, memory loss, confusion, headache, heart palpitations, chest pain, pain with deep breaths, dizziness, and rapid heartbeat.

Remdesivir cut COVID-19 recovery time by 5 days

Final data from a large study of Gilead Sciences Inc’s antiviral drug remdesivir showed the treatment cut COVID-19 recovery time by five days among hospitalized patients, one day faster than preliminary data had indicated, researchers reported on Thursday in The New England Journal of Medicine. The 1,062-patient study compared up to up to 10 days of therapy with remdesivir – now sold in some markets as Veklury – to a placebo. The average recovery time was 10 days among those who got the Gilead drug versus 15 days in the placebo group. Among patients requiring oxygen at the start, those taking remdesivir continued to need oxygen for an average of 13 days, compared to 21 days for patients who got a placebo. In a separate analysis looking just at patients who received oxygen, the drug appeared to reduce the risk of death over the next month by 70%. “We now have data suggesting that giving remdesivir to patients on oxygen may significantly reduce their chances of death compared to other subgroups,” Dr. Andre Kalil, an infectious disease expert at the University of Nebraska Medical Center and the study’s lead investigator, said in a news release.

Coronavirus rarely travels from mother to newborn

Transmission of the new coronavirus from mothers to newborns is rare, doctors from New York-Presbyterian/Columbia University Irving Medical Center reported on Monday in JAMA Pediatrics. They studied 101 babies born to 100 mothers with COVID-19, including 10 whose mothers had been severely ill. Almost all of the babies tested negative for the virus, while tests in two newborns had indeterminate results. If these two indeterminate results are considered positive, the overall incidence of transmission was 2.0%. Even with a 2% transmission rate, “none of our babies exhibited clinical symptoms of COVID-19, either during their newborn nursery stay or during … the first few weeks of life,” coauthor Dr. Dani Dumitriu told Reuters Health by email. Roughly 90% of the newborns were breastfed at least partially. “As the country heads into what looks like a second wave of the COVID-19 pandemic, it is important to know that separation of affected mothers from their newborns may not be warranted, and direct breastfeeding appears to be safe,” study coauthor Dr. Melissa Stockwell said.

(Reporting by Nancy Lapid, Julie Steenhuysen and Will Boggs; Editing by Bill Berkrot)

U.S. CDC reports 214,108 deaths from coronavirus

(Reuters) – The U.S. Centers for Disease Control and Prevention (CDC) on Monday reported 7,740,934 cases of the new coronavirus, an increase of 46,069 from its previous count, and said that the number of deaths had risen by 494 to 214,108.

The CDC reported its tally of cases of the respiratory illness known as COVID-19, caused by a new coronavirus, as of 4 pm ET on Oct. 11 versus its previous report a day earlier.

The CDC figures do not necessarily reflect cases reported by individual states.

(Reporting by Dania Nadeem in Bengaluru; Editing by Devika Syamnath)

U.S. CDC reports 210,232 deaths from coronavirus

(Reuters) – The U.S. Centers for Disease Control and Prevention (CDC) on Wednesday reported 7,475,262 cases of the new coronavirus, an increase of 38,984 from its previous count, and said that the number of deaths had risen by 672 to 210,232.

The CDC reported its tally of cases of the respiratory illness known as COVID-19, caused by a new coronavirus, as of 4 pm ET on Oct. 6 versus its previous report a day earlier.

The CDC figures do not necessarily reflect cases reported by individual states.

(Reporting by Dania Nadeem in Bengaluru; Editing by Devika Syamnath)

U.S. CDC reports 209,560 deaths from coronavirus

(Reuters) – The U.S. Centers for Disease Control and Prevention (CDC) on Tuesday reported 7,436,278 cases of the new coronavirus, an increase of 39,548 from its previous count, and said that the number of deaths had risen by 361 to 209,560.

The CDC reported its tally of cases of the respiratory illness known as COVID-19, caused by a new coronavirus, as of 4 pm ET on Oct. 5 versus its previous report a day earlier.

The CDC figures do not necessarily reflect cases reported by individual states.

(Reporting by Dania Nadeem in Bengaluru; Editing by Shounak Dasgupta)

In face of COVID-19 spike, New York Orthodox Jews take holiday prayers outside

By Gabriella Borter

MONSEY, N.Y. (Reuters) – Standing at least six feet apart and wearing skullcaps, prayer shawls and face masks, about two dozen Orthodox Jewish men pored over texts this week on a lawn in New York’s Monsey suburb, filling a quiet morning with the soft hum of Hebrew prayer.

Rather than crowd into a synagogue, the group has congregated outside a neighbor’s house each day to observe the week-long festival of Sukkot, one of many Jewish holidays this time of year coinciding with a sharp rise in coronavirus cases among members of this insular religious community.

Rockland County, encompassing Monsey and lying about 40 miles (64 km) north of New York City, is one of the state’s most troubled hotspots. Since March, nearly 700 of its people have died from COVID-19, more than in 15 individual U.S. states, according to a Reuters tally.

A recent spike in infections after a summer lull has been a somber reminder that the virus is still spreading, especially in places where large groups gather for religious or other reasons without adhering to public health guidance.

“The community had such terrible losses in the early days, and the last thing we need is to have such things happen again,” said Rabbi Asher Bush of Congregation Ahavat Yisrael in the Rockland village of Wesley Hills. “That would be utter, utter catastrophe.”

The open-air service is one of many adjustments that Orthodox Jews throughout the world have had to make in their traditions. The High Holiday season that includes the Jewish New Year and Yom Kippur, the Day of Atonement, is typically marked by mass prayer services, big family meals and travel. The celebrations traditionally feature group dancing. All of that now is forbidden because of the virus.

Two Rockland zip codes had positive coronavirus test rates top 15% over the weekend, compared to the state average of just over 1%, according to New York Governor Andrew Cuomo.

The viral spread has been especially acute in the Orthodox Jewish enclaves of Rockland County, as well as in New York’s Orange County and Brooklyn, areas where the governor says social distancing and mask-wearing have not been adequately enforced.

A drop in infection rates prompted some people – including, but not limited to, Orthodox Jews – to become more lax about mask-wearing and social distancing, several members of the Orthodox Jewish community told Reuters.

“It’s critically important for everybody to buy into this,” said Aaron Glatt, an associate rabbi at an Orthodox congregation in Woodmere, New York, and chief of infectious diseases at Mount Sinai South Nassau.

Tuvia Rotberg, a bookstore owner, hosted the outdoor Sukkot services in a white, open-air tent. He launched outdoor services for daily and Sabbath prayers just as the pandemic gripped New York in March and has kept them up, even though synagogues now are open with limited capacity.

‘PEOPLE ARE TRYING’

On Tuesday, Cuomo planned to meet with Orthodox Jewish leaders in Rockland and Orange counties and Brooklyn, after announcing the state would enforce mask mandates and social-distancing laws in those areas.

This week he ordered that schools be closed in 11 New York City neighborhoods where a high concentration of Orthodox Jews live. He also said he might enforce a new round of business and school shutdowns in Rockland County.

“I have to say to the Orthodox community tomorrow, if you’re not willing to live with these rules, then I’m going to close the synagogues,” Cuomo told reporters on Monday.

Health officials in Orange County on Tuesday shut down schools in the Village of Kiryas Joel and the Town of Palm Tree, which have large Orthodox Jewish populations, because of a burgeoning outbreak, News 12 Hudson Valley reported.

Rabbi Bush of Wesley Hills said his synagogue has been diligent about enforcing social distancing and masks, although he recently attended a service at another synagogue where other worshipers gathered in a tent outdoors without masks.

“There is a very large gamut of how different congregations are conducting themselves,” he said.

But if there was nonchalance at the end of the summer, recent hospitalizations of friends and family have forced many Orthodox Jews to acknowledge the severity of the situation, community members told Reuters.

“People are trying,” said Shoshana Bernstein, a communications professional in Monsey whose family has been attending outdoor services during Sukkot. “And if they weren’t doing the right thing last week, then more people are doing the right thing this week.”

(Reporting by Gabriella Borter; Editing by Howard Goller)