Second year of pandemic ‘could even be tougher’: WHO’s Ryan

GENEVA (Reuters) – The second year of the COVID-19 pandemic may be tougher than the first given how the new coronavirus is spreading, especially in the northern hemisphere as more infectious variants circulate, the World Health Organization (WHO) said on Wednesday.

“We are going into a second year of this, it could even be tougher given the transmission dynamics and some of the issues that we are seeing,” Mike Ryan, the WHO’s top emergencies official, said during an event on social media.

The worldwide death toll is approaching 2 million people since the pandemic began, with 91.5 million people infected.

The WHO, in its latest epidemiological update issued overnight, said after two weeks of fewer cases being reported, some five million new cases were reported last week, the likely result of a letdown of defenses during the holiday season in which people – and the virus – came together.

“Certainly in the northern hemisphere, particularly in Europe and North America we have seen that sort of perfect storm of the season – coldness, people going inside, increased social mixing and a combination of factors that have driven increased transmission in many, many countries,” Ryan said.

Maria Van Kerkhove, WHO’s technical lead for COVID-19, warned: “After the holidays, in some countries the situation will get a lot worse before it gets better.”

Amid growing fears of the more contagious coronavirus variant first detected in Britain but now entrenched worldwide, governments across Europe on Wednesday announced tighter, longer coronavirus restrictions.

That includes home-office requirements and store closures in Switzerland, an extended Italian COVID-19 state of emergency, and German efforts to further reduce contacts between people blamed for failed efforts, so far, to get the coronavirus under control.

“I worry that we will remain in this pattern of peak and trough and peak and trough, and we can do better,” Van Kerkhove said.

She called for maintaining physical distancing, adding: “The further, the better…but make sure that you keep that distance from people outside your immediate household.”

(Reporting by Stephanie Nebehay in Geneva and John Miller in Zurich; editing by Mark Heinrich)

As coronavirus stalks Brazil’s Amazon, many die untreated at home

By Bruno Kelly and Gabriel Araujo

MANAUS (Reuters) – Shirlene Morais Costa died at her home in the northern Brazilian city of Manaus on Monday, likely the latest victim of a devastating new wave of COVID-19 that has returned to this isolated city deep in the Amazon rainforest.

The 53-year-old went to hospital with a cough and a fever, both symptoms of the coronavirus, but was sent home, according to her stepfather, Esteliano Lopes Filho, 74.

“Her death was swift… We called the ambulance, but it only arrived after she was dead,” he said. “We’re seeing death after death… It really is a terrible calamity.”

Brazil is home to the world’s second deadliest coronavirus outbreak after the United States, and Manaus was one of the first Brazilian cities to creak under a spiraling death and caseload from the first wave of the pandemic last year.

So many were infected that some scientists thought the city of 2 million people might have been approaching herd immunity. But that projection has proved well wide of the mark.

The state of Amazonas, where nearly 6,000 people have died from COVID-19, is now suffering a devastating second wave that is pushing emergency services to breaking point. Many people, like Morais Costa, are dying at home.

Beds for COVID-19 patients in the state reached an occupancy rate of over 98% this week, according to data from the Amazonas state health department. Occupancy in temporary facilities that provide assistance to critical patients for later referral to other points of the health network was at 131%.

There are currently 1,391 patients hospitalized with COVID-19 in the state, in addition to a further 603 people hospitalized with suspected cases, the data shows.

Last week, refrigerated containers were placed outside the main hospitals in Manaus for the first time since the pandemic’s April peak. The containers are used to store bodies as the city’s healthcare and burial services again become overwhelmed.

(Editing by Gabriel Stargardter and Rosalba O’Brien)

Europe extends and tightens lockdowns, with fingers crossed for vaccines

By Claudia Cristoferi and John Revill

ROME/ZURICH (Reuters) – Governments across Europe announced tighter and longer coronavirus lockdowns and curbs on Wednesday amid fears of a fast-spreading variant first detected in Britain, with vaccinations not expected to help much until the spring.

Vaccines are being rolled out across the continent, but not as quickly as many countries had wished, and the effects are not expected until inoculations are widespread among the population.

Italy will extend its COVID-19 state of emergency to the end of April, Health Minister Roberto Speranza said as infections show no sign of abating.

Switzerland announced tighter measures to tackle new variants of the COVID-19 virus and extended the closure of restaurants, cultural and sport sites by five weeks to run until the end of February.

Germany is also likely to have to extend COVID-19 curbs into February, Health Minister Jens Spahn said, stressing the need to further reduce contacts to fend off the more infectious variant first identified in Britain.

The German cabinet approved stricter entry controls to require people arriving from countries with high caseloads or where the more virulent variant is circulating to take coronavirus tests.

Chancellor Angela Merkel told a meeting of lawmakers on Tuesday that the coming 8 to 10 weeks would be very hard if the more infectious variant spread to Germany, according to a participant at the meeting.

Health Minister Spahn told Deutschlandfunk radio it would take another two or three months before the vaccination campaign really started to help.

The Dutch government said late on Tuesday it would extend the lockdown, including the closure of schools and shops, by at least three weeks until Feb. 9.

“This decision does not come as a surprise, but it is an incredible disappointment,” Prime Minister Mark Rutte told a news conference, adding that the threat posed by the new variant was “very, very worrying”.

He said the government was considering imposing a curfew, but was reluctant and had sought outside advice before deciding on such severe restrictions.

In France, President Emmanuel Macron was discussing possible tighter rules with senior ministers. A nationwide curfew could be brought forward to 6 p.m. from 8 p.m., as has already happened in parts of the country, French media reported.

The French government’s top scientific adviser said new restrictions were needed in light of the variant first detected in Britain, adding that if vaccines were more widely accepted the crisis could be over by September.

“The coming three months will be difficult, the situation will slightly improve during the spring but should really get better at the end of the summer,” Jean-François Delfraissy told franceinfo radio.

In Switzerland, officials cancelled the Lauberhorn World Cup downhill race, out of fear that the new variant – brought in by what health authorities said was a single British tourist – was spreading now spreading rapidly among locals.

At least 60 people have tested positive in the Alpine resort of Wengen in the last four weeks.

Switzerland, which has so far taken a lighter touch to restricting business and public life than its neighbors, said it will close shops selling non-essential supplies from Monday.

It also ordered companies to require that employees work from home where possible. The country also eased rules on allowing pandemic-hit businesses to apply for state financial aid in hardship cases.

There was more optimistic news from Poland, where COVID-19 case numbers have stabilized after surging in the autumn.

“I hope that in two to three weeks the restrictions will be a little smaller, the vaccine will work,” Poland’s Finance Minister Tadeusz Koscinski said in an interview for Money.pl.

“Some restrictions will remain for quite a long time, but I think that 80% of these restrictions will start to disappear at the turn of the first and second quarter.”

(Reporting by Anthony Deutsch and Bart Meijer in Amsterdam, John Miller in Zurich, Benoit Van Overstraeten in Paris, Sabine Siebold and Hans-Edzard Busemann in Berlin, Pawel Florkiewicz in Warsaw, writing by Emma Thomasson; editing by Philippa Fletcher and Nick Macfie)

Oil hits 11-month high near $57 on tight supply expectations

By Laura Sanicola

NEW YORK (Reuters) – Oil hit an 11-month high just below $57 a barrel on Tuesday, bolstered by Saudi Arabia’s plans to limit supply, offsetting worries that rising coronavirus cases globally would curtail fuel demand.

Brent crude was up 90 cents, or 1.6%, at $56.56 a barrel by 1118 EST (1618 GMT) after touching its highest since last February at $56.75. U.S. West Texas Intermediate (WTI) gained 82 cents, or 1.6%, to $53.07.

Saudi Arabia plans to cut output by an extra 1 million barrels per day (bpd) in February and March to keep inventories in check.

The Saudi cut is part of an OPEC-led deal in which most producers will hold output steady in February. Last year’s record cuts from OPEC and its allies helped oil recover from historic lows reached in April. Some analysts believe the oil complex is underestimating supply levels.

“Storage at Cushing is only 10.2 million barrels below the all-time record high, so there is no problem with supply here in the U.S., but the complex is responding positively to this chatter about undersupply,” said Bob Yawger, director of energy futures at Mizuho.

Oil also gained on expectations for a drop in U.S. crude stockpiles. Analysts expect crude inventories to fall by 2.7 million barrels for a fifth straight week of declines.

The first of this week’s two supply reports, from the American Petroleum Institute, is due at 4:30 p.m. EST (2130 GMT).

The market is also being supported by the prospect of increased economic stimulus in the United States. President-elect Joe Biden, who takes office on Jan. 20, has promised “trillions” in extra pandemic-relief spending.

However, oil price gains were capped by demand concerns as coronavirus cases rise around the world.

Chinese authorities introduced new curbs in areas surrounding Beijing on Tuesday and Japan is to widen a state of emergency beyond Tokyo.

(Additional reporting by Alex Lawler and Jessica Jaganathan; Editing by Kirsten Donovan, David Goodman and David Gregorio)

Two gorillas at San Diego Zoo test positive for COVID-19

By Steve Gorman

LOS ANGELES (Reuters) – Two gorillas at the San Diego Zoo have tested positive for COVID-19 after exhibiting symptoms of the disease, California’s governor said on Monday, in what is believed to be the first known transmission of the virus to apes.

Governor Gavin Newsom, in his latest coronavirus update for the state, said the source of the gorillas’ infection was still under investigation to determine whether the virus was transmitted between animals or from humans to the apes.

A statement posted on the San Diego Zoo Safari Park website said the gorillas were suspected of having contracted infection “from an asymptomatic staff member,” despite following all COVID-19 safety precautions recommended by the U.S. Centers for Disease Control and Prevention.

Zoo authorities initiated testing of fecal samples of the park’s gorillas after two of the apes began coughing last Wednesday, and preliminary results two days later found the presence of the virus “in the gorilla troop,” the statement said.

The U.S. Department of Agriculture National Veterinary Services Laboratories confirmed the positive results on Monday.

“The test results confirm the presence of SARS-CoV-2 in some of the gorillas and does not definitively rule out the presence of the virus in other members of the troop,” it said.

“Aside from some congestion and coughing, the gorillas are doing well,” Lisa Peterson, executive director of the San Diego Zoo Safari Park, said in the statement. “The troop remains quarantined together and are eating and drinking. We are hopeful for a full recovery.”

Gorillas are members of the family of primates known as the great apes, or hominids, that also include orangutans, chimpanzees and humans.

The coronavirus has also been found in a number of other wild-animal species in captivity, including several lions and tigers at the Bronx Zoo in New York and four lions at the Barcelona Zoo in Spain.

But the gorillas in San Diego are believed to mark the first known case of infections confirmed in apes. The virus also has shown up in a number of household dogs and cats.

Last month, the USDA said it had confirmed the first known case of the coronavirus in an animal in the wild, a mink, following an outbreak among farmed minks that killed 15,000 of the animals.

(Reporting by Steve Gorman in Los Angeles; Editing by Leslie Adler and Peter Cooney)

COVID-19 patients still have symptoms 6 months later; interferon may be helpful treatment after all

By Nancy Lapid

(Reuters) – The following is a roundup of some of the latest scientific studies on the novel coronavirus and efforts to find treatments and vaccines for COVID-19, the illness caused by the virus.

Half a year later, COVID-19 patients still have symptoms

Most patients hospitalized with COVID-19 have at least one symptom six months after falling ill, according to findings from a study in Wuhan, China, where the novel coronavirus first emerged in late 2019. Doctors there tracked 1,733 patients who were diagnosed and hospitalized between January, 2020 and May. Six months later, 76% had at least one symptom including fatigue or muscle weakness (seen in 63%), sleep difficulties and anxiety or depression. Most of those who had been severely ill had ongoing lung problems and chest abnormalities that could indicate organ damage, while 13% of patients whose kidneys functioned normally in the hospital went on to develop kidney problems later, researchers reported on Friday in The Lancet. “We are only beginning to understand” some of the long-term effects of COVID-19, study coauthor Bin Cao from the China-Japan Friendship Hospital in Beijing said in a statement. “Our analysis indicates that most patients continue to live with at least some of the effects of the virus after leaving hospital,” highlighting the need for post-discharge care.

Interferon boosts proteins that deny entry to coronavirus

An experimental inhaled form of interferon being tested for treating hospitalized COVID-19 patients may not have a limitation researchers had feared. A potential problem with interferon is that it increases levels of a protein called ACE2, which the new coronavirus uses as a gateway into cells. In test tube experiments, researchers looked at cells that line the path from the nose into the lungs and discovered there are actually two forms of ACE2 – the well known one and a short form that lacks the entryway used by the virus. Interferon increases the short form of ACE2 but not the longer form, they found, which means it does not appear to boost entry points for the virus. “We were excited to discover a new form of ACE2,” Dr. Jane Lucas of the University of Southampton, who co-led the study reported on Monday in Nature Genetics, said in a statement. “We believe this may have important implications for managing COVID-19 infection.” An inhaled interferon from Synairgen Plc is being tested in late-stage trials.

Saliva viral load improves prediction of COVID-19 severity

The amount of the new coronavirus in saliva might help guide doctors’ care of patients because it is a better predictor of disease course than viral load in swab samples obtained from the nose and the back of the throat, researchers said. They studied 26 mildly ill COVID-19 patients, 154 hospitalized patients – including 63 who became critically ill and 23 who eventually died – and 108 uninfected individuals. Saliva viral load, but not nasopharyngeal viral load, was linked with COVID-19 risk factors like age and gender, and with immune system responses. Saliva viral load was also superior to nasopharyngeal viral load at predicting critical illness and death, the researchers reported on Wednesday on medRxiv ahead of peer review. Saliva contains inhaled germs that are cleared from the lungs by the body’s protective mechanisms, coauthor Akiko Iwasaki of Yale University explained in a tweet on Sunday. The saliva viral load therefore reflects how well the virus is making copies of itself all the way through the respiratory tract, from the nose to the lungs, and not just in the nose and back of the throat, Iwasaki said.

(Reporting by Nancy Lapid; Editing by Bill Berkrot)

U.S. sets COVID-19 death record for second week, cases surge

(Reuters) – The United States lost more than 22,000 lives to COVID-19 last week, setting a record for the second week in a row, as new cases also hit a weekly high.

California was the state with the most deaths at 3,315 in the week ended Jan. 10, or about eight out of every 100,000 people, up 44% from the prior week, according to a Reuters analysis of state and county reports.

Arizona had the highest death rate per capita at 15 per 100,000 residents, followed by Rhode Island at 13 and West Virginia at 12 deaths per 100,000 people.

On average, COVID-19 killed 3,239 people per day in the United States last week, more than the number killed by the Sept. 11 attacks in 2001.

Cumulatively, nearly 375,000 people in the country have died from the novel coronavirus, or one in every 873 residents. The total could rise to more than 567,000 by April 1, according to a forecast from the Institute for Health Metrics and Evaluation (IHME).

The United States reported more than 1.7 million new cases of COVID-19 last week, up 17% from the prior seven days. Former U.S. Food and Drug Administration chief Scott Gottleib said new cases could start declining in February.

“By the end of this month, we’ll have infected probably about 30% of the American public and maybe vaccinated another 10%, notwithstanding the very difficult rollout of the vaccine,” Gottleib told CNBC on Friday. “You’re starting to get to levels of prior exposure in the population where the virus isn’t going to spread as readily.”

Across the United States, 13.4% of tests came back positive for the virus, down from 13.6% the prior week, according to data from the volunteer-run COVID Tracking Project. The highest rates were in Iowa at 59%, Idaho at 54% and Alabama at 45%.

(Graphic by Chris Canipe, writing by Lisa Shumaker, editing by Tiffany Wu)

Global coronavirus cases surpass 90 million in battle on new variant

By Roshan Abraham and Anurag Maan

(Reuters) – Worldwide coronavirus cases surpassed 90 million on Monday, according to Reuters tally, as nations around the globe scramble to procure vaccines and continue to extend or reinstate lockdowns to fight new coronavirus variants.

The new COVID-19 variants discovered initially in the United Kingdom and South Africa are rapidly spreading globally.

The novel coronavirus has picked up pace in the past few months with about one-third of total cases registered in the last 48 days, according to a Reuters tally.

Europe, which became the first region to report 25 million cases last week, remains the worst-affected area in the world, followed by North and Latin Americas with 22.4 million and 16.3 million cases respectively.

Europe has reported around 31% of about 1.93 million coronavirus-related deaths globally.

The United Kingdom, the worst-affected European country, crossed 3 million cases last Friday.

The nation is on course to have immunized its most vulnerable people against COVID-19 by mid-February and plans to offer a shot to every adult by autumn.

To control the spread of new coronavirus variant, countries across the globe have started to extend movement and business restrictions.

In Germany, Chancellor Angela Merkel and state premiers last week agreed to restrict non-essential travel for residents of hard-hit areas all over Germany for the first time, after a lockdown decreed in December failed to significantly reduce infection numbers.

French authorities imposed a stricter evening curfew in Marseille after authorities said the new variant of the COVID-19 virus initially found in the UK had been discovered in the Mediterranean city.

The United States, world’s worst affected country, reported its highest death toll on Wednesday, with over 4,000 fatalities in a single day.

The nation has recorded more than 22 million cases since the pandemic started, reporting on average 245,000 new infections a day over the last seven days, according to a Reuters analysis.

In Asia, India crossed 150,000 deaths last Tuesday, becoming the third nation to reach the grim milestone.

The south Asian nation has approved two COVID-19 vaccines and will start its vaccination drive from Jan. 16 with priority given to about 30 million healthcare and frontline workers.

(Reporting by Roshan Abraham and Anurag Maan in Bengaluru; Editing by Lisa Shumaker and Michael Perry)

17 million doses of COVID-19 vaccines distributed, 4.8 million administered: U.S. CDC

(Reuters) – The U.S. Centers for Disease Control and Prevention said it had administered 4,836,469 first doses of COVID-19 vaccines in the country as of Tuesday morning and distributed 17,020,575 doses.

The tally of vaccine doses distributed and the number of people who received the first dose are for both Moderna and Pfizer/BioNTech, vaccines as of 9:00 a.m. ET on Tuesday, the agency said.

According to the tally posted on Jan. 4, the agency had administered 4,563,260 first doses of the vaccines and distributed 15,418,500 doses.

A total of 3,260,775 vaccine doses were distributed for use in long-term care facilities and 429,066 people in the facilities got their first dose, the agency said.

The agency also reported 20,732,404 cases of the new coronavirus, an increase of 173,915 cases from its previous count, and said that the number of deaths had risen by 1,800 to 352,464.

The CDC reported its tally of cases of the respiratory illness known as COVID-19, caused by a new coronavirus, as of 4 pm ET on Jan. 4 versus its previous report a day earlier.

The CDC figures do not necessarily reflect cases reported by individual states.

(Reporting by Dania Nadeem in Bengaluru; Editing by Devika Syamnath)

Germany introduces tougher restrictions in pandemic battle

By Andreas Rinke and Holger Hansen

BERLIN (Reuters) – Germany is extending its nationwide lockdown until the end of the month and introducing tougher new restrictions in an effort to curb surging coronavirus infections, Chancellor Angela Merkel said on Tuesday.

“We need to restrict contact more strictly… We ask all citizens to restrict contact to the absolute minimum,” Merkel told reporters after a meeting with the leaders of Germany’s 16 federal states.

The new rules restrict for the first time non-essential travel for residents of hard-hit areas all over Germany.

They limit movement to a 15-kilometre (nine-mile) radius in towns and districts where the number of new coronavirus cases is above 200 per 100,000 residents over seven days.

Members of any one household will be allowed to meet only one other person in public. That compares with a current rule under which public gatherings are limited to five people from two households.

Like many other European countries, Germany is struggling to contain a second wave of the virus. Britain began its third COVID-19 lockdown on Tuesday with citizens under orders to stay at home.

Concern is growing that hospitals in Germany will struggle to cope, and Merkel said a new mutation of the coronavirus first detected in Britain increased the need to be more cautious.

SHOPS, SCHOOLS TO STAY SHUT

Shops and restaurants will remain shut until the end of January. Schools are also to remain closed, with classes to be held online, until at least the end of the month.

“We believe these measures are justified, even if they are hard,” Merkel said.

The chancellor said she and the state leaders would review the new measures on Jan. 25.

The number of confirmed coronavirus cases in Germany rose by 11,897 to 1.787 million in the last day, the Robert Koch Institute for infectious diseases said on Tuesday. The death toll rose by 944 to 35,518.

Germany had imposed a partial lockdown in November but was forced to close schools, shops and restaurants in mid-December after the initial steps failed to have the desired impact.

Germany is rolling out a vaccine against COVID-19 but the media and some officials have criticized the government for a slow start and for ordering too few doses. By Tuesday, around 317,000 people had received a shot.

(Additional reporting by Madeline Chambers, Joseph Nasr and Sabine Siebold; writing by Madeline Chambers and Maria Sheahan, Editing by Alexandra Hudson and Gareth Jones)