As U.S. vaping injuries taper off, new evidence points to vitamin E

As U.S. vaping injuries taper off, new evidence points to vitamin E
By Julie Steenhuysen

CHICAGO (Reuters) – The U.S. Centers for Disease Control and Prevention released a series of reports on Friday indicating that the outbreak of vaping-related lung injuries appears to be waning, as evidence mounts that vitamin E acetate, a cutting agent used in marijuana vape cartridges, is playing a role in the illnesses.

So far, 54 people have died and more than 2,500 have been hospitalized in the outbreak, which started in the summer and spread to all 50 states, the District of Columbia, and two U.S. territories.

In a telephone briefing with reporters, Dr. Anne Schuchat, principal deputy director of the CDC, said evidence now suggests that vitamin E acetate was increasingly being added to cartridges containing THC – the high-producing compound in marijuana – beginning in June, when the outbreak began to ramp up.

Schuchat said THC vaping “largely explains” the big increase in acute cases that spiked over the summer, but the findings do not imply that nicotine vaping is entirely safe.

In one report, published in the New England Journal of Medicine, public health officials found that emergency room visits for the vaping lung injuries rose sharply beginning in June and peaked in September. Since then, emergency room visits have tapered off but still remain higher than when the outbreak started in June.

In a second report in the New England Journal, researchers report that additional testing of lung samples from people who had vaping injuries strengthens earlier studies pointing to vitamin E acetate as a likely culprit in the outbreak.

The study, which looked at lung samples from patients in 16 states, found vitamin E acetate in 94 percent of lung samples taken from patients who vaped THC.

In a separate study in the CDC’s Mortality and Morbidity Weekly Report, of the 2,409 people whose cases were reported to the CDC as of Dec. 10, thirty-one patients who had been discharged got sick again and had to be readmitted to the hospital, and seven people died shortly after discharge.

Patients who got sick after discharge tended to have a history of heart disease, respiratory conditions and diabetes. Those who died after discharge were more likely to be 50 or older.

With these cases, the CDC is now recommending that patients be clinically stable at the time of discharge, and that they follow up with a doctor within two days of discharge. CDC’s earlier guidance called for a two-week follow-up.

(Reporting by Vishwadha Chander; Editing by Shounak Dasgupta and Steve Orlofsksy)

U.S. vaping-related deaths rise to 42, cases of illness to 2,172

U.S. vaping-related deaths rise to 42, cases of illness to 2,172
(Reuters) – U.S. health officials on Thursday reported 2,172 confirmed and probable cases and 3 more deaths from a mysterious respiratory illness tied to vaping, taking the death toll to 42, so far this year.

Last week, the Centers for Disease Control and Prevention reported 2,051 confirmed and probable U.S. lung injury cases and 39 deaths associated with use of e-cigarettes, or vaping products.

As of Nov. 13, 42 deaths have been confirmed in 24 states and the District of Columbia, the agency said. (http://bit.ly/2NrLYXW)

Health officials last week also dubbed the discovery of Vitamin E acetate — believed to be used as a cutting agent in illicit vaping products containing marijuana components — in all lung samples from 29 patients as a breakthrough in their investigation.

Investigators have not linked the cases to any specific product or compound, but have pointed to vaping oils containing THC, the psychoactive ingredient in marijuana, as being especially risky.

(Reporting by Manas Mishra and Saumya Sibi Joseph in Bengaluru; Editing by Shounak Dasgupta)

U.S. vaping-related deaths climb to 39, illnesses to 2,051

U.S. vaping-related deaths climb to 39, illnesses to 2,051
(Reuters) – U.S. health officials on Thursday reported 2,051 confirmed and probable cases and 2 more deaths from a mysterious respiratory illness tied to vaping, taking the total death toll to 39.

Last week, the Centers for Disease Control and Prevention reported 1,888 cases and 37 deaths from the illness.

As of Nov. 5, 39 deaths have been confirmed in 24 states and the District of Columbia, the agency said.

Investigators have not linked the cases to any specific product or compound, but have pointed to vaping oils containing THC, the psychoactive ingredient in marijuana, as being especially risky.

(Reporting by Manojna Maddipatla and Saumya Sibi Joseph in Bengaluru in Bengaluru; Editing by Shailesh Kuber)

U.S. vaping-related deaths rise to 37, cases of illness to 1,888

U.S. vaping-related deaths rise to 37, cases of illness to 1,888
(Reuters) – U.S. health officials on Thursday reported 1,888 confirmed and probable cases and 3 more deaths from a mysterious respiratory illness tied to vaping, taking the total death toll to 37.

Last week, the Centers for Disease Control and Prevention (CDC) reported 1,604 cases and 34 deaths from the illness and said the number of reported cases in the epidemic appears to be leveling off or declining.

However, the CDC said last week it was too early to say whether the outbreak had peaked.

(Reporting by Manojna Maddipatla and Saumya Sibi Joseph in Bengaluru; Editing by Shinjini Ganguli)

U.S. vaping-related deaths rise to 12, illnesses climb to 805

FILE PHOTO: A man uses a vaping product in the Manhattan borough of New York, New York, U.S., September 17, 2019. REUTERS/Carlo Allegri

(Reuters) – U.S. health officials on Thursday reported 805 confirmed and probable cases and 12 deaths so far from a mysterious respiratory illness tied to vaping, with the outbreak showing no signs of losing steam.

Last week, the U.S. Centers for Disease Control and Prevention (CDC) reported 530 cases and seven deaths due to severe lung illnesses.

U.S. public health officials have been investigating these illnesses, but have not linked it to any specific e-cigarette product.

As of Sept. 24, the confirmed deaths were reported in California, Florida, Georgia, Illinois, Indiana, Kansas, Minnesota, Mississippi, Missouri, and Oregon, the CDC said.

The House of Representatives began public hearings about the illness this week while Massachusetts imposed a four-month ban on sales of all vaping products, including those used for tobacco and marijuana, which is legal in the state.

Investigators have, however, pointed to vaping oils containing marijuana ingredient tetrahydrocannabinol (THC) or vitamin E acetate, a substance used in some THC products, as a possible cause of these illnesses.

The increased scrutiny also prompted leading e-cigarette maker Juul Labs to suspend all broadcast, print and digital product advertising in the United States and bring in a longtime Altria Group Inc executive as its CEO.

Altria owns a 35% stake in Juul.

Public health officials have advised consumers to quit vaping and urged those who continue using the devices to avoid buying such products on the street, using marijuana-derived oil with the products or modifying a store-bought vape product.

(Reporting by Saumya Sibi Joseph in Bengaluru; Editing by Saumyadeb Chakrabarty and Shounak Dasgupta)

U.S. cases of vaping-related illness rise to 530 as outbreak widens

By Julie Steenhuysen

CHICAGO (Reuters) – U.S. health officials said on Thursday there are now 530 confirmed and probable cases and seven deaths from severe lung-related illnesses tied to vaping, and there are no signs that the outbreak is easing.

That’s up from 380 cases reported a week ago.

The U.S. Food and Drug Administration is now investigating 150 products and substances and said it has activated its criminal investigations arm to explore the supply chain of vaping products and identify the cause of the outbreak. No individual vapers will be targeted, Mitch Zeller, director of the FDA’s Center for Tobacco Products.

Zeller said no single substance or compound, including THC or Vitamin E acetate, has been linked to all of the cases so far.

Seven people have died from vaping-related illness, the Centers for Disease Control and Prevention (CDC) said. The deaths were reported in California (2), Illinois, Indiana, Kansas, Minnesota, and Oregon.

Illinois has reported an 8th death related to the outbreak, state epidemiologist Dr. Jennifer Layden said on a conference call with reporters. The CDC has not yet confirmed that death.

Layden said Illinois has now reported 69 cases, up from 52 a week ago, and the state continues to get reports of new cases daily.

(Reporting by Julie Steenhuysen; Editing by Sonya Hepinstall)

‘It is time to stop vaping’: Kansas reports sixth U.S. death linked to mystery illness

By Matthew Lavietes

(Reuters) – A Kansas resident was the sixth person to die in the United States of a mysterious respiratory illness related to vaping, state officials said on Tuesday, as public health officials scrambled to understand a nationwide health problem.

“It is time to stop vaping,” Kansas State Health Officer Dr. Lee Norman Norman said in a statement. “If you or a loved one is vaping, please stop.”

U.S. public health officials are investigating 450 cases of vaping-related lung illness across 33 states and one U.S. territory. The nationwide investigation led by the U.S. Centers for Disease Control and Prevention and the U.S. Food and Drug Administration has not linked the illnesses to any specific e-cigarette product.

Many of the reported illnesses involved vaping products, including cannabis products, containing vitamin E acetate, an oil derived from vitamin E that can be dangerous if inhaled. The vaping industry has blamed the surge in the contagion on black market products, but health officials have yet to rule out any vaping devices as a potential cause.

“We agree with the FDA — if you don’t want to die or end up in a hospital, stop vaping illegal THC oils immediately,” said a spokesman from the American Vaping Association. “If you’re an adult smoker or ex-smoker who vapes store-bought nicotine products, don’t listen to the activists who would rather you inhale deadly smoke than vape.”

Symptoms among the reported cases included shortness of breath, fever, cough and vomiting. Additional indicators have included headache, dizziness and chest pain.

To date, Kansas has six cases associated with the outbreak. Health officials disclosed that the individual who died was over the age of 50 and had a history of underlying health issues, according to the statement. No other information was provided to protect patient confidentiality.

“Our sympathies go out to the family of the person who died,” Governor Laura Kelly said in the statement. “I urge Kansans to be careful. Don’t put yourself in harm’s way, and please follow the recommendations of public health officials.”

The American Medical Association on Monday urged Americans to stop using electronic cigarettes of any sort until scientists have a better handle on the illnesses.

(Reporting by Matthew Lavietes in New York; Editing by Scott Malone and David Gregorio)