New Year, New Virus: This is concerning new Coronavirus that causes brain infection

bioRXiv

Important Takeaways:

  • Lethal Infection of Human ACE2-Transgenic Mice Caused by SARS-CoV-2- related Pangolin Coronavirus
  • SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR) can cause 100% mortality in human ACE2-transgenic mice, potentially attributable to late-stage brain infection. This underscores a spillover risk of GX_P2V into humans and provides a unique model for understanding the pathogenic mechanisms of SARS-CoV-2-related viruses.

Read the original article by clicking here.

U.S. denounces terms for WHO-led inquiry into COVID origins

By Stephanie Nebehay

GENEVA (Reuters) – The United States, which has accused China of having hidden the extent of its coronavirus outbreak, called on Tuesday for a “transparent and inclusive” WHO-led international investigation into the origin of the pandemic, criticizing its current terms.

The Trump administration has accused the World Health Organization of being “China-centric” and of being its puppet, which WHO director-general Tedros Adhanom Ghebreyesus has denied.

The virus, known as SARS-CoV-2, is believed to have emerged in the Chinese central city of Wuhan late last year, possibly from bats at a market with live animals.

Chinese scientists are carrying out research into its origins and how it jumped the species barrier. A WHO-led international team formed in September is to develop plans for longer-term studies building on China’s findings, according to the WHO’s published terms of reference.

Garrett Grigsby, head of the global affairs office at the U.S. Department of Health and Human Services, told the WHO’s ministerial assembly that member states had been informed of the investigation’s terms of reference only a few days ago.

The terms were “not negotiated in a transparent way with all WHO member states” and “the investigation itself appears to be inconsistent” with its mandate, he said, without elaborating.

“Understanding the origins of COVID-19 through a transparent and inclusive investigation is what must be done to meet the mandate,” Grigsby said.

Britain called for prioritizing the probe, adding: “We expect the investigation and its outcomes to be grounded in robust science.”

Sun Yang, of China’s National Health Commission, did not mention the investigation in his speech on Tuesday, but said that China supports “WHO’s continued leadership role”.

German Health Minister Jens Spahn, speaking for the European Union on Monday, called for “full transparency and cooperation” during all phases of the investigation.

WHO’s top emergency expert Mike Ryan said on Oct. 30 that the WHO-led team and its Chinese counterparts had held a first virtual meeting regarding joint investigations and would deploy on the ground in time.

A separate independent panel said on Tuesday it was working to establish “an accurate and authoritative chronology” behind the first outbreaks and responses. Former New Zealand Prime Minister Helen Clark and former Liberian President Ellen Johnson Sirleaf were named in July to co-lead the WHO panel.

Trump announced a temporary halt to U.S. funding to the WHO in April, prompting condemnation from many world leaders. The United Nations said in July it had received formal notification of the U.S. decision to leave the body next year.

(Reporting by Stephanie Nebehay; Editing by Catherine Evans and Nick Macfie)

Mutation in new coronavirus increases chance of infection: study

(Reuters) – A specific mutation in the new coronavirus can significantly increase its ability to infect cells, according to a study by U.S. researchers.

The research may explain why early outbreaks in some parts of the world did not end up overwhelming health systems as much as other outbreaks in New York and Italy, according to experts at Scripps Research.

The mutation, named D614G, increased the number of “spikes” on the coronavirus – which is the part that gives it its distinctive shape. Those spikes are what allow the virus to bind to and infect cells.

“The number—or density—of functional spikes on the virus is 4 or 5 times greater due to this mutation,” said Hyeryun Choe, one of the senior authors of the study.

The researchers say that it is still unknown whether this small mutation affects the severity of symptoms of infected people, or increases mortality.

The researchers conducting lab experiments say that more research, including controlled studies – widely considered a gold standard for clinical trials, needs to be done to confirm their findings from test tube experiments.

Older research has showed that the new coronavirus SARS-CoV-2 is mutating and evolving as it adapts to its human hosts. The D614G mutation in particular has been flagged as an urgent concern because it appeared to be emerging as a dominant mutation.

The Scripps Research study is currently undergoing peer review and was released on Friday amid reports of its findings.

(Reporting by Manas Mishra in Bengaluru: Editing by Bernard Orr)