‘My second life’: California nurse walks out of hospital after 8-month COVID-19 ordeal

By Steve Gorman

LONG BEACH, Calif. (Reuters) – As a veteran ICU nurse whose job is to care for the most critically ill patients at her hospital in Long Beach, California, Merlin Pambuan was well aware of the deadly ravages COVID-19 can inflict on the human body.

Last spring in a tragic role reversal, Pambuan became one of those patients – admitted to the intensive care unit of St. Mary Medical Center, her workplace for the past 40 years, where she was rendered unconscious by paralysis-inducing sedation and placed on a ventilator to breathe. A feeding tube was later added.

She came close to death on several occasions, her doctors later revealed. So dire was her condition at one point that end-of-life options were discussed with her family.

By the time she awoke and could breathe on her own again, she was too weak to stand. But she fought back and struggled through weeks of painful therapy to regain her strength and mobility, celebrating her 66th birthday in St. Mary’s acute rehabilitation ward in late October.

On Monday Pambuan beat the odds of her eight-month ordeal by walking out the front door of the hospital, drawing cheers, applause and exhilaration from colleagues lining the lobby to rejoice in her discharge.

“This is my second life,” Pambuan said moments earlier, as she prepared to leave her hospital room, accompanied by her husband, Daniel, 63, and their daughter, Shantell, 33, an aspiring social worker who spent months at her mother’s bedside as her patient advocate and personal cheerleader.

The spectacle of Pambuan striding slowly but confidently through the hospital lobby – she had insisted on making her exit without assistance of a wheelchair or walker, although was still connected to supplementary oxygen – marked a transformative victory for the diminutive but tough ICU nurse.

‘WHAT WE LIVE FOR’

The outpouring of affection she received from colleagues – including many of the physicians, fellow nurses and therapists who took part in her care – also reflected a rare moment of communal triumph for the pandemic-weary hospital staff.

“This is what we live for … seeing our patients going home alive and in good condition,” said Dr. Maged Tanios, a pulmonary and critical care specialist at St. Mary. He said Pambuan’s recovery was especially rewarding since she is part of the hospital’s extended “family.”

Tanios said he was not aware of other St. Mary medical staff being admitted to the ICU for COVID. However, studies show frontline healthcare workers’ frequent, close contact with coronavirus patients puts them at higher risk of contracting the disease, hence the decision to give them top priority in getting immunized.

Pambuan’s discharge, ironically, coincided with the recent rollout of COVID-19 vaccines to medical workers, as well as a crushing surge in coronavirus infections that have overwhelmed hospitals, and ICUs in particular, across California.

Pambuan said she has no recollection of the four months she spent hooked to a breathing machine – from early May to early September – but recalls first waking up from deep sedation unable to move her extremities.

With encouragement from nursing staff and her daughter Pambuan said she grew determined to regain her mobility and her life.

“I said, ‘No, I’m going to fight this COVID,'” she recounted. “I start moving my hand (and) a physical therapist come and say, ‘Oh, you’re moving your hands,’ and I said, ‘Oh, I’m going to fight, I’m going to fight. I’m trying to wiggle my toes. I’m going to fight it.'”

Pambuan spent the last few months of her hospital stay undergoing physical and respiratory rehabilitation and will continue recuperation from home, while making peace, she said, with a change in pace.

“It’s going to be very difficult for me,” she said. “But I have to accept it, that I’m going to be on oxygen for a while and slow down a little bit.”

When or if she will return to work in the ICU remains an open question, she said.

In the meantime, Pambuan said she feels indebted to her co-workers for their “really professional” care, grateful for the support of loved ones and newly convinced of the power of optimism.

Her message to others in her shoes – “Don’t lose hope. Just fight. Fight, because look at me, you know. I’m going home and I’m walking.”

(Reporting by Steve Gorman in Long Beach, California; Editing by Lisa Shumaker)

We may soon have a COVID-19 vaccine. But will enough people take it?

By John Miller and Kate Kelland

ZURICH/LONDON (Reuters) – With COVID-19 vaccine trial results looking positive, governments and pharmaceutical firms face their next daunting challenge: convincing the world to get inoculated.

Public resistance to vaccines has been much discussed this year, but the issue became very real on Monday when Pfizer and BioNTech announced their candidate was more than 90% effective in large trials – hoisting an actual shot onto the horizon.

Numerous opinion polls carried out before and during the pandemic showed confidence is volatile, and that political polarization and online misinformation threatens uptake. Many people have concerns about the accelerated speed of COVID-19 vaccine development.

The World Health Organization estimates about 70% of people must be inoculated to break transmission of the virus. Since it is unlikely a vaccine, once approved, will be immediately available for the masses, experts said getting medical workers on board will be critical.

“We should have really targeted discussions and engagement with healthcare providers,” Heidi Larson, director of the global Vaccine Confidence Project, told Reuters.

“Not only are they going to be the first ones expected to get a vaccine – if not required to – they’re also going to be the ones on the frontlines facing the onslaught of questions from the public.”

FIRST IN LINE?

While about 200 COVID-19 vaccine candidates are in development globally, with dozens in human clinical trials, no shot has actually crossed the finish line and been approved, though the one from Pfizer-BioNTech appears to be on track.

The high rate of efficacy in the Pfizer-BioNTech interim results could help boost confidence, Cornell University government Professors Douglas Kriner and Sarah Kreps said.

Their recently published research showed that if an initial COVID-19 vaccine was about as effective as a flu shot, uptake by the American public may fall far short of the 70% level needed to achieve “herd immunity.”

“However, if the vaccine was 90% effective it would significantly increase Americans’ willingness to vaccinate by more than 10%, critical to ensuring enough public acceptance to help the U.S. eventually get closer to herd immunity,” said Kreps.

Experts are also cautioning any conversation over a vaccine’s risks and rewards must be frank. A return to normal life will still take time, with no one shot likely to be a silver bullet. And many questions are likely to remain, including how long a vaccine will provide protection.

The Reagan-Udall Foundation for the FDA, a non-profit that supports the U.S. Food and Drug Administration, has been holding focus groups to gauge the public mood and is now crafting campaign messages to help tackle concerns.

Its chief executive, Susan Winckler, said more than a dozen focus groups of 150 people in total held since August – some in person, some by video – had unearthed numerous concerns.

“We heard distrust of both government and the healthcare system,” Winckler said. “Many didn’t want to be first in line for the shot.”

It’s a global phenomenon; a survey from early November, carried out by the World Economic Forum and covering 18,526 people in 15 countries, showed 73% of people willing to get a COVID-19 vaccine, a four-point fall since August.

EARLY BATTLE

Regulators and the drug industry have taken pains to reassure the public they won’t cut corners on safety, with a top U.S. drug agency official saying he would quit if an unproven vaccine were rubber stamped.

The International Federation of Pharmaceutical Manufacturers & Associations, a drug industry group, also plans a campaign by 2021, while the U.S. Council for International Business, with 300 multinational corporations as members, is also getting behind a campaign pushing for workforce take-up of eventual COVID-19 vaccines.

Some studies show government and employer recommendations will help convince people to get vaccinated.

Scott Ratzan, co-leader with Larson of ‘CONVINCE’, an initiative supporting communication and engagement for vaccine uptake globally, stressed the importance of medical workers getting inoculated, saying others would then be more likely to follow suit.

“If we don’t have the medical folks signed on … we’ll lose the early battle,” he added. “The only way to get back to normal is if we can get enough workers or employees covered.”

(Reporting by John Miller in Zurich and Kate Kelland in London; Additional reporting by Martinne Geller in London, Doug Busvine in Frankfurt and Julie Steenhuysen in Chicago; Editing by Josephine Mason and Pravin Char)

China’s Li pledges medical reinforcements as virus toll hits 81

China’s Li pledges medical reinforcements as virus toll hits 81
By Winni Zhou and Josh Horwitz

SHANGHAI (Reuters) – Chinese Premier Li Keqiang will “inspect and direct” efforts to control a virus outbreak in the central city of Wuhan and promised reinforcements, as provincial authorities faced accusations from the public of a failure to respond in time.

World shares slipped to their lowest in two weeks as worries grew about the economic impact of the coronavirus after China, the world’s second-biggest economy, ramped up travel bans and extended the Lunar New Year holidays.

Li, clad in a blue protective suit and mask, thanked medical workers in Wuhan, the capital of Hubei province and the epicenter of the outbreak, as the death toll rose to 81.

“Li … thanked frontline medical workers for their all-out efforts in treating patients and urged them to pay attention to their own protection,” Xinhua news agency said.

“He required efforts to guarantee medical resources supply, race against time to treat patients and ensure adequate market supply and stable prices.”

He said 2,500 more medical workers would arrive in the next two days.

Li is the most senior leader to visit Wuhan since the outbreak began. He inspected efforts to contain the epidemic and was shown on state television leading medical workers in chants of “Wuhan jiayou!” – an exhortation to keep their strength up.

He also visited the construction site of a new hospital due to be built in days.

On China’s heavily censored social media, where dissent is typically suppressed, local officials have borne the brunt of mounting public anger about the handling of the virus.

Some lashed out at the Hubei governor, who had to correct himself twice during a news conference over the number of face masks being produced in the province.

“If he can mess up the data multiple times, no wonder the disease has spread so severely,” one Weibo user said.

Wuhan Mayor Zhou Xianwang told state broadcaster CCTV the city’s management of the crisis was “not good enough” – rare public self-criticism for a Chinese official – and said he was willing to resign.

The city of 11 million people is in virtual lockdown and much of Hubei, home to nearly 60 million people, is under some kind of travel curb.

People from Hubei have come under scrutiny within mainland China as well, with many facing suspicion from officials about their recent travels.

“Hubei people are getting discriminated against,” a Wuhan resident complained on the Weibo social media platform.

SHARES TUMBLE

A small number of cases linked to people who traveled from Wuhan have been confirmed in more than 10 countries, including Thailand, France, Japan and the United States, but no deaths have been reported outside China.

Investors are worried about the impact on travel, tourism and broader economic activity. The consensus is that in the short term, economic output will be hit as Chinese authorities impose travel restrictions and extend the week-long Lunar New Year holiday, when millions traditionally travel by rail, road and plane, by three days to limit the spread of the virus.

Asian and European shares tumbled, with Japan’s Nikkei average sliding 2%, its biggest one-day fall in five months. Demand spiked for safe-haven assets such as the Japanese yen and Treasury notes. European stocks fell more than 2%.

During the 2002-2003 outbreak of Severe Acute Respiratory Syndrome (SARS), a coronavirus that originated in China and killed nearly 800 people globally, air passenger demand in Asia plunged 45%. The travel industry is more reliant on Chinese travelers now than it was then.

The total number of confirmed cases in China rose to 2,835, with about half in the central province of Hubei. But some experts suspect the number of infected people is much higher.

Chinese-ruled Hong Kong, which has had eight confirmed cases, banned entry to people who had visited Hubei in the past 14 days.

The number of deaths from the virus in Hubei climbed to 76 from 56, officials said, with five deaths elsewhere in China.

WHO DIRECTOR ARRIVES IN CHINA

The newly identified coronavirus is believed to have originated late last year in a Wuhan market illegally selling wildlife. Much is not known, including how easily it spreads and just how deadly it is.

National Health Commission Minister Ma Xiaowei said on Sunday the incubation period could range from one to 14 days, and the virus was infectious during incubation, unlike SARS.

The World Health Organization (WHO) estimated an incubation period of two to 10 days.

WHO Director-General Tedros Adhanom Ghebreyesus had arrived in China and would meet officials working on the response, his agency said.

Some of China’s biggest companies have been affected, with hotpot restaurant chain Haidilao International Holding shutting branches nationwide from Sunday until Friday.

Gaming giant Tencent Holdings Ltd advised staff to work from home until Feb. 7, and e-commerce firm Alibaba removed vendors’ offers of overpriced face masks from its online Taobao marketplace as prices surged.

(Reporting by Winni Zhou, Wu Huizhong, Sun Yilei and Josh Horwitz; Additional reporting by Hideyuki Sano in Tokyo, Lidia Kelly in Sydney, Stephanie Ulmer-Nebehay in Geneva, Kate Kelland in London; Writing by Robert Birsel, Tony Munroe and Nick Macfie; Editing by Clarence Fernandez and Alison Williams)