Novavax begins mid-stage study of COVID-19 vaccine in South Africa

(Reuters) – U.S. drug developer Novavax Inc said on Monday it started a mid-stage study of its experimental COVID-19 vaccine in South Africa, as the country experiences a surge in coronavirus cases.

South Africa is the fifth worst affected country with 583,653 coronavirus cases and 11,677 deaths, according to a Reuters tally.

“Because South Africa is experiencing a winter surge of COVID-19 disease, this important Phase 2b clinical trial has the potential to provide an early indication of efficacy,” Novavax research chief Gregory Glenn said.

The trial of Novavax’s NVX-CoV2373, backed by a $15 million grant from Bill & Melinda Gates Foundation, was being conducted in two separate groups, one comprising 2,665 healthy volunteers and the other, 240 HIV-positive adults.

Novavax expects its vaccine, once approved, would be supplied to South Africa through a deal signed earlier this year with the Serum Institute of India to develop and commercialize NVX-CoV2373.

The vaccine candidate is one of nearly 30 globally being tested in human clinical trials.

Early-stage data from a small clinical trial of the vaccine has shown that it produced high levels of virus-fighting antibodies, and the company aims to begin larger studies to obtain regulatory approvals as early as December.

Novavax intends to begin Phase 2 of the small clinical trial in the United States and Australia in the near future and said it would include about 1,500 candidates. It also aims to begin Phase III as soon as late September.

The U.S. government in July awarded Novavax $1.6 billion to cover testing its potential coronavirus vaccine in the United States and manufacturing with the aim of delivering a 100 million doses by January.

(Reporting by Sabahatjahan Contractor and Manas Mishra in Bengaluru; Editing by Amy Caren Daniel and Shinjini Ganguli)

Trump approves emergency aid for Iowa after storm

(Reuters) – U.S. President Donald Trump on Monday said he approved federal disaster aid for Iowa after a hurricane-force storm hit last week, causing widespread damage in towns and farms and leaving thousands without power.

Iowa Governor Kim Reynolds said on Sunday she requested about $4 billion in emergency funds following the Aug. 10 storm.

The destruction compounded troubles for a U.S. agricultural economy already battered by extreme weather, the U.S.-China trade war and disruptions to labor and food consumption from the COVID-19 pandemic.

“I just approved an emergency declaration for Iowa,” Trump told reporters at the White House before departing on a trip to the Midwest. “It really did a lot of damage,” he said of the storm.

Trump, who is scheduled to speak on Monday in Minnesota and Wisconsin, said he aimed to visit Iowa.

“I’ll be going very soon and maybe today,” he said.

Media reports said the storm caused at least three deaths in Iowa. Winds as high as 100 miles per hour (160 kph) hit eastern Nebraska, Iowa, Wisconsin and parts of Illinois.

The storm impacted 37.7 million acres of farmland across the Midwest, including 14 million in Iowa, the Iowa Soybean Association said on Friday, citing estimates from the U.S. Department of Agriculture.

“I’ve never seen the corn flattened as much as it has from this terrific windstorm,” U.S. Senator Charles Grassley of Iowa told reporters on Monday. “The number of grain bins flattened is humongous.”

The storm affected 58,000 holders of crop-insurance policies with a liability of around $6 billion in Iowa, according to the Iowa Soybean Association.

Grassley said crop insurance covers about 90% of Iowa farmland. It is too early to determine whether there will be enough storage space for the autumn harvest, he said.

(Reporting by Kanishka Singh in Bengaluru; Steve Holland; in Washington; and Tom Polansek in Chicago; Editing by Nick Macfie and Dan Grebler)

What you need to know about the coronavirus right now

(Reuters) – Here’s what you need to know about the coronavirus right now:

Concern over U.S. autumn resurgence

The United States surpassed 170,000 coronavirus deaths on Sunday, according to a Reuters tally.

U.S. public health officials and authorities are concerned about a possible resurgence in cases in the autumn at the start of the flu season, which will likely exacerbate efforts to treat the coronavirus.

The United States has at least 5.4 million confirmed cases of the coronavirus, the highest in the world and likely an under count as the country still has not ramped up testing to the recommended levels. Cases are falling in most states except for Hawaii, South Dakota and Illinois.

Pandemic spreads in India

India’s COVID-19 death toll surpassed 50,000 on Monday and the total number of recorded cases neared 2.65 million as the outbreak spread further into smaller towns and rural areas, government data showed.

The world’s second-most populous country recorded 57,981 new infections in the last 24 hours, raising the total to 2,647,663, while an additional 941 deaths raised the overall death toll to 50,921.

India is only the third country, behind the United States and Brazil, to record more than 2 million infections. Experts have said India’s testing rates are far too low.

South Korea battles worst outbreak in months

South Korea warned of a looming coronavirus crisis as new outbreaks flared, including one linked to a church where more than 300 members of the congregation have been infected but hundreds more are reluctant to get tested.

The outbreak linked to the Sarang Jeil Church in Seoul is the country’s biggest in nearly six months and led to a tightening of social distancing rules on Sunday.

The Korea Centers for Disease Control and Prevention (KCDC) reported 197 new cases as of midnight on Saturday, most in the Seoul metropolitan area, marking the fourth day of a three-digit tally. “We’re seeing the current situation as an initial stage of a large-scale transmission,” KCDC director Jeong Eun-kyeong told a briefing.

New Zealand postpones election

New Zealand Prime Minister Jacinda Ardern postponed the general election by a month to Oct. 17, bowing to pressure after some parties complained they could not campaign with nearly a third of New Zealand’s 5 million people under lockdown in Auckland.

Ardern’s opponents accuse her of using the pandemic to shore up support as she appears on television nearly every day to reassure New Zealanders, while other party leaders struggle to get attention. Her rivals are hoping Ardern loses some of her appeal once economic hardships caused by the lockdown begin to bite.

“Shocking” rise in Lebanon

Lebanon must shut down for two weeks after a surge in infections, the caretaker health minister said on Monday, as the country reels from the massive Beirut port blast.

“We are all facing a real challenge and the numbers that were recorded in the last period are shocking,” Hamad Hassan said. “The matter requires decisive measures.” Intensive care beds at state and private hospitals were now full, he added.

Lebanon on Sunday registered a record 439 new infections and six more deaths from the virus in 24 hours.

The country, already deep in financial crisis, was struggling with a COVID-19 spike before the Aug. 4 blast that killed at least 178 people, wrecked swathes of the capital and pushed the government to resign.

(Compiled by Linda Noakes and Karishma Singh; Editing by Nick Macfie)

U.S. coronavirus death toll hits 170,000 ahead of fall flu season

(Reuters) – The United States surpassed 170,000 coronavirus deaths on Sunday, according to a Reuters tally, as health officials express concerns over COVID-19 complicating the fall flu season.

Deaths rose by 483 on Sunday, with Florida, Texas and Louisiana, leading the rise in fatalities.

The United States has at least 5.4 million confirmed cases in total of the novel coronavirus, the highest in the world and likely an under count as the country still has not ramped up testing to the recommended levels. Cases are falling in most states except for Hawaii, South Dakota and Illinois.

Public health officials and authorities are concerned about a possible fall resurgence in cases amid the start of the flu season, which will likely exacerbate efforts to treat the coronavirus.

Centers for Disease Control Director Robert Redfield warned the United States may be in for its “worst fall” if the public does not follow health guidelines in an interview with Web MD.

Months into the pandemic, the U.S. economic recovery from the recession triggered by the outbreak is still staggered, with some hot spots slowing their re-openings and others shutting down businesses.

The Institute for Health Metrics and Evaluation is anticipating an uptick in COVID-19 cases in the coming months, resulting in around 300,000 total deaths by December, and a nearly 75% increase in hospitalizations.

Worldwide there are at least 21.5 million coronavirus cases and over 765,000 confirmed deaths. The United States remains the global epicenter of the virus, with around a quarter of the cases and deaths.

(Reporting by Aurora Ellis; editing by Diane Craft)

U.S. CDC reports 5,228,817 coronavirus cases

(Reuters) – The U.S. Centers for Disease Control and Prevention (CDC) on Friday reported 5,228,817 cases of the new coronavirus, an increase of 52,799 cases from its previous count, and said that the number of deaths had risen by 1,169 to 166,317.

The CDC reported its tally of cases of the respiratory illness known as COVID-19, caused by a new coronavirus, as of 4 pm ET on Aug. 13 versus its previous report a day earlier.

The CDC figures do not necessarily reflect cases reported by individual states.

(Reporting by Trisha Roy in Bengaluru; Editing by Devika Syamnath)

Beirut blast halts American-Lebanese woman’s final journey home

By Callaghan O’Hare and Maria Caspani

HOUSTON (Reuters) – Rami Basbous was on the phone with his uncle in Beirut on August 4, making arrangements to return his mother’s remains from the United States to her birthplace, when he heard the blast that reduced large parts of the Lebanese capital to rubble.

The explosion, the biggest in Beirut’s history, killed at least 172 people, injured some 6,000 and triggered protests against Lebanon’s political elite. It also put an end to the Basbous family’s plan to bury a beloved wife and mother alongside her relatives.

“Before the blast and riots we had a very large set of hurdles to get through but it was doable,” said Rami, 21, after his mother’s funeral on Wednesday in Houston, Texas. “After the blast and now the riots we have a very slim chance at getting her there safely.”

Rita Basbous died earlier this month at age 53 in Houston, weeks after undergoing heart surgery. Rita, whose health was already compromised by a decades-long struggle with diabetes and related kidney problems, contracted the coronavirus in April and fought it through May.

She eventually recovered, her son said, although the illness left her weak.

“She loved the world,” Rami said of his mother, who was born in Lebanon, spoke five languages and lived in Mauritania and the United States, following her father to his postings as a civil engineer.

After the Basbous family settled in Houston, Rita worked as a teacher and dedicated much of her time to volunteering and helping fellow immigrants, her son said.

Mask-clad mourners occupied every other row of pews at her funeral service at Our Lady of the Cedars Maronite Church in Houston. Pink and white roses adorned her casket.

In a time of pandemic, the family said they were grateful to be able to hold an in-person funeral at all.

The son, Rami, said restrictions imposed by the pandemic forced them to get creative and live stream the funeral for family and friends unable to attend.

For now, Rita has been buried at a Houston area cemetery. The family still hopes to return her remains to Lebanon but the unrest in Beirut, coupled with the health issues raised by coronavirus, have put those plans on hold for now.

“We joke that that was her telling us ‘no’,” Rami said.

(Reporting by Callaghan O’Hare in Houston, Texas; Writing by Maria Caspani; Editing by Diane Craft)

U.S. CDC reports 5,176,018 coronavirus cases

(Reuters) – The U.S. Centers for Disease Control and Prevention (CDC) on Thursday reported 5,176,018 cases of the new coronavirus, an increase of 56,307 cases from its previous count, and said that the number of deaths had risen by 1,497 to 165,148.

The CDC reported its tally of cases of the respiratory illness known as COVID-19, caused by a new coronavirus, as of 4 pm ET on Aug. 12 versus its previous report a day earlier.

The CDC figures do not necessarily reflect cases reported by individual states.

(Reporting by Trisha Roy in Bengaluru; Editing by Shailesh Kuber)

U.S. CDC reports 5,064,171 coronavirus cases

(Reuters) – The U.S. Centers for Disease Control and Prevention (CDC) on Tuesday reported 5,064,171 cases of the novel coronavirus, an increase of 40,522 cases from its previous count, and said that the number of deaths had risen by 565 to 162,407.

The CDC reported its tally of cases of the respiratory illness known as COVID-19, caused by the new coronavirus, as of 4 p.m. ET on Aug. 10 versus its previous report a day earlier.

The CDC figures do not necessarily reflect cases reported by individual states.

(Reporting By Mrinalika Roy in Bengaluru; Editing by Maju Samuel)

Mexico to conduct late-stage trials for China, US COVID-19 vaccines

MEXICO CITY (Reuters) – Mexico will conduct late-stage clinical trials for COVID-19 vaccines in development by Johnson & Johnson and two Chinese companies, the foreign ministry said on Tuesday.

Large-scale, phase three human testing for the J&J unit Janssen Pharmaceuticals’ candidate could start in the second half of September, the company has previously said.

Mexico will also help test candidates for Chinese companies CanSino Biologics Inc and Walvax Biotechnology Co Ltd, the ministry said in a presentation at a news conference.

More than 150 vaccines are being developed and tested around the world to stop the COVID-19 pandemic, with 25 in human clinical trials, according to the World Health Organization.

Russia is the first country to approve a COVID-19 vaccine, which it named ‘Sputnik V’ for foreign markets, an official said on Tuesday.

Johnson & Johnson kicked off U.S. human safety trials in July for its COVID-19 vaccine after releasing details of a study in monkeys that showed its best-performing vaccine candidate offered strong protection in a single dose.

Walvax’s experimental vaccine is currently under early testing at a Chinese military research institute.

CanSino Biologics’ vaccine candidate is already in clinical trials. The company is also collaborating with Canada’s National Research Council to “pave the way” for future trials in Canada, the research council in May.

Mexico has lobbied in world forums including at the G20 group of nations and the United Nations to secure equitable access for an eventual vaccine.

Latin America’s second largest economy has suffered more than 50,000 deaths from COVID-19, according to official data, making it the third country with most deaths globally.

It ranks 13th adjusted for deaths per capita, according to Johns Hopkins University School of Medicine.

(Reporting by Frank Jack Daniel; Editing by Chizu Nomiyama and Alistair Bell)

Global coronavirus cases hit 20 million: Reuters tally

By Gayle Issa

(Reuters) – Global coronavirus cases pushed past 20 million on Monday, according to a Reuters tally, with the United States, Brazil and India accounting for more than half of all known infections.

The respiratory disease has infected at least four times the average number of people struck down with severe influenza illnesses annually, according to the World Health Organization.

The death toll from COVID-19, meanwhile, at more than 728,000 has outpaced the upper range of annual deaths from the flu.

The Reuters tally, which is based on government reports, shows the disease is accelerating. It took almost six months to reach 10 million cases after the first infection was reported in Wuhan, China, in early January. It took just 43 days to double that tally to 20 million.

Experts believe the official data likely under counts both infections and deaths, particularly in countries with limited testing capacity.

The United States is responsible for around 5 million cases, Brazil 3 million and India 2 million. Russia and South Africa round out the top ten.

The pandemic is accelerating fastest in Latin America which accounts for almost 28% of the world’s cases and more than 30% of deaths, according to the Reuters tally.

With the first wave of the virus yet to peak in some countries and a resurgence of cases in others, governments are still divided in their responses. Some countries are reintroducing strict public health measures, while others continue to relax restrictions.

Health experts expect dilemmas about how to proceed with school, work and social life to last – and restrictions to fluctuate – until a vaccine is available.

The vaccine race has more than 150 candidates being developed and tested around the world with 25 in human clinical trials, according to the World Health Organization.

In the United States, children began returning to their classrooms last week, even as controversy over school safety swirled.

Britain has added both Spain and Belgium to a list of countries from which returning travelers must quarantine at home for 14 days because of fresh upticks in some European locations.

In Asia, China continues to squash surges using strict, local lockdowns, bringing its daily numbers down into the low double digits on the mainland.

Australia has introduced a strict lockdown and night curfew in the city of Melbourne, aiming to stifle an outbreak there. Neighboring New Zealand, where life has largely returned to normal, on the weekend recorded 100 days with no new cases of local transmission.

(Reporting by Gayle Issa; editing by Jane Wardell)