Tag Archives: COVID-19

Delta variant already dominant in U.S., CDC estimates show

By Mrinalika Roy

(Reuters) – The Delta variant is already the dominant strain of COVID-19 in the United States, according to data modeling done by the U.S. Centers for Disease Control and Prevention (CDC).

According to the health agency’s estimates the Delta variant became dominant in the country over the two weeks ended July 3, with 51.7% cases linked to the variant that was first identified in India.

The proportion of cases linked to the Alpha variant which was first identified in Britain and had been dominant in the United States so far, fell to 28.7%.

The data, which shows the estimated biweekly proportions of the most common SARS-CoV-2 lineages circulating in the United States, is based on sequences collected through CDC’s national genomic surveillance since Dec. 20, 2020.

The Delta variant, which is becoming dominant in many countries, is more easily transmitted than earlier versions of the coronavirus and may cause more severe disease, especially among younger people. It has now been found in every U.S. state, health officials have said.

On Tuesday, U.S. President Joe Biden encouraged Americans who have not yet been vaccinated against COVID-19 to get their shots to protect themselves from the widely spreading, highly contagious variant.

So far, preliminary data has shown that vaccines made by Pfizer Inc and BioNTech, AstraZeneca and Moderna are largely protective against Delta, with the concentration of virus-neutralizing antibodies being somewhat reduced.

(Reporting by Mrinalika Roy in Bengaluru; Editing by Sandra Maler)

Vaccines may curb new virus mutations; teens use soft drinks to fake positive COVID-19 tests

By Nancy Lapid

(Reuters) – The following is a roundup of some of the latest scientific studies on the novel coronavirus and efforts to find treatments and vaccines for COVID-19, the illness caused by the virus.

COVID-19 vaccines may be curbing new virus mutations

Along with preventing illness and deaths, COVID-19 vaccines may also be curbing the “rampant evolution” of the new coronavirus by limiting new mutations that allow it to evade antibodies, researchers believe. As part of a larger study, they closely analyzed gene sequences in virus samples obtained from 30 COVID-19 patients who had not been vaccinated and 23 vaccinated individuals with so-called breakthrough cases of COVID-19. In particular, they looked at genes associated with the spike the virus uses to break into cells. The spikes are targeted by the antibodies unleashed by current treatments and vaccines. The more the spike mutates, or changes, the less likely the antibodies will be fully effective. Compared to virus samples from unvaccinated patients, samples from vaccine breakthrough patients showed significantly fewer mutations on the spike, researchers from data analytics company nference reported on Monday on medRxiv ahead of peer review. The more people get infected, the more opportunities the virus has to mutate as it makes copies of itself inside the body. It is possible that by suppressing the number of copies made in vaccinated people, the chances to mutate are reduced as well, the authors suggest. “This study presents the first known evidence that COVID-19 vaccines are fundamentally restricting the … escape pathways accessible to SARS-CoV-2,” they concluded.

Some teens are faking positive COVID-19 tests

Teenagers have figured out how to use soft drinks to fake a positive COVID-19 test, and the authors of a new study warn schools and other groups to be aware. As of July 1, videos uploaded to social media under the search term #fakecovidtest, featuring young people applying various liquids to rapid antigen COVID-19 tests, had been viewed millions of times, according to the British news website inews.co.uk. That report, and others, prompted University of Liverpool researchers to study the effects of applying soft drinks and artificial sweeteners to the test swabs. All four sweeteners tested produced negative results on rapid COVID-19 tests, as did spring water. But 10 of 14 soft drinks produced positive or weakly positive results, with no apparent link between the test results and the soft drinks’ ingredients, the researchers reported on Monday on medRxiv ahead of peer review. Since March, UK schools have asked pupils without symptoms to test twice weekly, the authors note. A positive test can result in an entire class having to isolate at home. Based on their findings, they advise, testing “should be performed first thing in the morning, prior to the consumption of any food or drinks, and supervised where feasible.”

Rapid COVID-19 tests are generally reliable

Used properly, “rapid antigen” COVID-19 tests that give fast results are generally reliable, a new study suggests. The tests have “good” sensitivity, or the ability to correctly identify patients who are infected with the coronavirus, and “excellent” specificity, or the ability to correctly identify people who are not infected, UK researchers reported in The Lancet Microbe. Unlike gold-standard PCR tests, which involve complex lab equipment and highly trained staff, rapid antigen tests can be processed on the spot. The researchers evaluated six commercially available tests. Compared to PCR, their accuracy at diagnosing infection varied from 65% to 89% and rose above 90% in patients with high viral loads. The researchers warn that correct use of the tests is essential, which may happen less often with members of the public than when administered by trained healthcare workers. Although PCR-based testing is more accurate, they conclude, the rapid tests’ “versatility in terms of cost and portability,” and their usefulness in disrupting transmission from infected asymptomatic individuals who would otherwise go undetected “could outweigh the risk of missing positive cases.”

(Reporting by Nancy Lapid and Megan Brooks; Editing by Bill Berkrot)

WHO urges countries ‘not to lose gains’ by prematurely lifting COVID-19 measures

ZURICH/BENGALARU (Reuters) -World Health Organization emergencies head Michael Ryan urged countries on Wednesday to use extreme caution when lifting COVID-19 restrictions so as “not to lose the gains you’ve made”.

Ryan’s comments come as England, hosting Europe’s soccer championships, prepares to end many COVID-19 restrictions on July 19, European countries ease travel curbs and Indian states relax their lockdowns, despite accelerating infections with the Delta variant worldwide.

Ryan said that while every nation must decide for itself, individuals including the unvaccinated must take responsibility to protect themselves and others, to keep hospitals from being overwhelmed by another pandemic wave.

“The idea that everyone is protected, and it’s ‘Kumbaya’ and everything goes back to normal, I think right now is a very dangerous assumption anywhere in the world, and it’s still a dangerous assumption in the European environment,” he told reporters during a meeting from Geneva.

“We would ask governments at this moment not to lose the gains you’ve made.”

Ahead of reopening, British Prime Minister Boris Johnson has said the epidemiological situation may be aided by the arrival of summer and school holidays.

Ryan said he believed British scientists were “very aware of the threat represented by variants, especially the Delta variant” and would open cautiously.

The WHO also urged countries including the United States and Switzerland that are vaccinating 12- to 15-year-old children to instead donate doses to the vaccine sharing program COVAX, to improve access for healthcare workers and the elderly in low-income countries.

“It’s not the pediatric population that is suffering the most,” said WHO vaccine expert Ann Lindstrand. “It is the adults, it is the medical risk groups.”

(Reporting by John Miller in Zurich and Manas Mishra in Bengaluru, Editing by Michael Shields and Nick Tattersall)

Israel sees drop in Pfizer vaccine protection against infections, still strong in severe illness

JERUSALEM (Reuters) – Israel reported on Monday a decrease in the effectiveness of the Pfizer/BioNTech COVID-19 vaccine in preventing infections and symptomatic illness but said it remained highly effective in preventing serious illness.

The decline coincided with the spread of the Delta variant and the end of social distancing restrictions in Israel.

Vaccine effectiveness in preventing both infection and symptomatic disease fell to 64% since June 6, the Health Ministry said. At the same time the vaccine was 93% effective in preventing hospitalizations and serious illness from the coronavirus.

The ministry in its statement did not say what the previous level was or provide any further details. However ministry officials published a report in May that two doses of Pfizer’s vaccine provided more than 95% protection against infection, hospitalization and severe illness.

A Pfizer spokesperson declined to comment on the data from Israel, but cited other research showing that antibodies elicited by the vaccine were still able to neutralize all tested variants, including Delta, albeit at reduced strength.

About 60% of Israel’s 9.3 million population have received at least one shot of Pfizer’s vaccine in a campaign that saw daily cases drop from more than 10,000 in January to single digits last month.

This spurred Israel to drop nearly all social distancing as well as the requirement to wear masks, though the latter was partially reimposed in recent days. At the same time Delta, which has become a globally dominant variant of the coronavirus, began to spread.

Since then daily cases have gradually risen, reaching 343 on Sunday. The number of seriously ill rose to 35 from 21.

Data scientist Eran Segal of Israel’s Weizmann Institute of Science said the country was unlikely to experience the high levels of hospitalizations seen earlier in the year since there were much fewer critically ill.

He said it was fine to “continue with life back to normal and without restrictions” while stepping up measures like vaccination outreach and ensuring testing for Israelis returning home from abroad.

(Reporting by Ari Rabinovitch and Maayan Lubell, Editing by William Maclean)

Russia reports record 737 COVID-19 deaths, changes entry rules

MOSCOW (Reuters) – Russia on Tuesday reported a record 737 deaths from coronavirus-linked causes in the past 24 hours as the country stepped up efforts to vaccinate its population of more than 144 million people.

A new surge in COVID-19 cases in June was blamed on the new, highly infectious, Delta variant. Moscow responded with mandatory vaccination for a wide group of citizens, a model adopted by other regions, sparking wide public discontent ahead of September parliamentary elections.

Health minister Mikhail Murashko said up to 850,000 people were being vaccinated against COVID-19 in Russia every day, and that building immunity across the population was key, the TASS new agency reported.

Murashko said foreign producers of COVID-19 vaccines had applied to register in Russia, without disclosing their names.

Russia has so far offered its own vaccines against the novel coronavirus, launching a mass vaccination campaign in late 2020.

From Wednesday, Russia will change the rules for citizens returning from abroad, scrapping the obligation to undergo two PCR tests upon arrival, a decree published on Tuesday and signed by Anna Popova, head of the consumer health watchdog, showed.

From July 7, all those vaccinated or officially recovered from COVID-19 do not need to take a PCR test. Those who do not fall into these two categories when they enter Russia, will need to self-isolate before receiving results of one PCR test.

In the past day, Russia has confirmed 23,378 new COVID-19 cases, including 5,498 in Moscow, taking the official national tally since the pandemic began to 5,658,672.

The Kremlin said it would not support the idea of closing borders between Russia’s regions to stop the virus from spreading, although some regions may take swift and harsh measures to withstand the pandemic.

The recent surge in COVID-19 cases, along with the need to raise interest rates to combat inflation, are seen challenging economic growth in Russia this year.

(Reporting by Andrey Ostroukh and Gleb Stolyarov; additional reporting by Olzhas Auyezov; Editing by Catherine Evans, William Maclean)

Lack of side effects doesn’t mean mRNA vaccine not working; mRNA shots limit breakthrough infection severity

By Nancy Lapid

(Reuters) – The following is a roundup of some of the latest scientific studies on the novel coronavirus and efforts to find treatments and vaccines for COVID-19, the illness caused by the virus.

Lack of vaccine side effects no cause for concern

While a variety of side effects after receiving an mRNA COVID-19 vaccine may be a sign of the immune system kicking into high gear, a lack of such reactions does not mean it has failed to respond, researchers have found. They tested 206 hospital employees for antibodies against the coronavirus before and after receipt of the vaccine from Pfizer and BioNTech and surveyed them about vaccine-related reactions. As in clinical trials, arm pain was the most common symptom, reported by 91% after the first shot and 82% after the second. Systemic symptoms, such as feeling weak or tired, or having body aches or pains, were reported by 42% and 28%, respectively, after the first shot and by 62% and 52% after the second shot. But there was no correlation between vaccine symptom severity and antibody levels one month after vaccination, the researchers reported on Friday in a paper posted on medRxiv ahead of peer review. The researchers said the findings should reassure people that a lack of side effects after getting the mRNA shots does not mean the vaccine is not working as intended. The Moderna shot also uses mRNA technology.

mRNA vaccines limit severity of rare breakthrough infections

In the rare cases of COVID-19 that occur after vaccination, patients are likely to be sick for less time and have milder symptoms than if they were unvaccinated, according to a U.S. study of nearly 4,000 healthcare personnel, first responders, and other frontline workers. In participants who were tested weekly since mid-December, COVID-19 has been diagnosed in five who were fully vaccinated with an mRNA vaccine from either Pfizer and BioNTech or Moderna, 11 who were partially protected, having received either one shot or were less than 14 days out from their second, and 156 who were unvaccinated. Most unvaccinated patients were sick for at least two weeks, compared with only one week for vaccinated patients, the researchers reported on Wednesday in The New England Journal of Medicine. Patients who were fully or partially vaccinated had 58% lower odds of fever and spent an average of 2.3 fewer days in bed than unvaccinated patients. Their viral loads also averaged 40% lower. “If you get vaccinated, about 90% of the time you’re not going to get COVID-19,” coauthor Dr. Jeff Burgess of the University of Arizona said in a statement. “Even if you do get it, there will be less of the virus in you and your illness is likely to be much milder.”

J&J vaccine shows promise against Delta variant in lab test

The single-shot COVID-19 vaccine from Johnson & Johnson showed promise against the highly contagious Delta coronavirus variant in a laboratory study posted on Thursday on bioRxiv ahead of peer review. Analyses of blood from eight recipients of the vaccine showed that its neutralizing antibody activity against the Delta variant, first identified in India, was reduced by 1.6-fold compared to an earlier version of the virus but is still higher than against the Beta variant, first identified in South Africa. In trials last year while the Beta variant was circulating in South Africa, the J&J vaccine showed 66% efficacy against moderate and severe disease. “We believe that our vaccine offers durable protection against COVID-19 and elicits neutralizing activity against the Delta variant,” J&J Chief Scientific Officer Paul Stoffels said. So far, preliminary data has shown that vaccines made by Pfizer and BioNTech, AstraZeneca and Moderna are largely protective against Delta, with the concentration of virus-neutralizing antibodies being somewhat reduced. Delta has become the variant of most concern around the world as it is more easily transmitted, may lead to more severe disease even in younger people, and is becoming the dominant virus version in many countries.

High COVID-19 rate seen in patients’ pets

In 20% of households where humans had COVID-19 or had recovered from it, cats and dogs also had antibodies to the virus, researchers from The Netherlands found. They visited 196 households where humans had tested positive within the previous 200 days, to test pet cats and dogs for the coronavirus and for antibodies that would indicate past infection. Thirteen animals – six cats and seven dogs – or 4.2%, had COVID-19, and 54 – 31 cats and 23 dogs (17.4%) – had coronavirus antibodies. There was no evidence that pets were passing the infection to each other. Owners reported no or mild symptoms in the infected animals. “If you have COVID-19, you should avoid contact with your cat or dog,” Dr. Els Broens of Utrecht University, whose team presented the data on Wednesday at the European Congress of Clinical Microbiology & Infectious Diseases, said in a statement. “The main concern, however, is not the animals’ health … but the potential risk that pets could act as a reservoir of the virus and reintroduce it into the human population.” To date, however, no pet-to-human transmission has been reported, he added. “It seems unlikely that pets play a role in the pandemic.”

(Reporting by Nancy Lapid, Aakriti Bhalla and Manas Mishra; Editing by Bill Berkrot)

Without ICUs, doctor in Jakarta hospital battles to help COVID-19 patients

By Yuddy Cahya Budiman

JAKARTA (Reuters) – Indonesian doctor Cheras Sjarfi says the small public hospital where she works in south Jakarta was not ready for the influx of COVID-19 patients who arrived after a surge of new infections in the world’s fourth-most-populous country.

Only equipped for basic health care, her facility has had to treat COVID-19 patients even though it lacks the life-saving ventilators and intensive care units they sometimes require.

“We weren’t prepared for this situation,” she said, adding that the situation at smaller hospitals like hers showed how severe things had become.

The 28-year-old general practitioner said she knew it was getting bad when all the patients classified as suspected coronavirus cases tested positive within a week.

Grappling with the worst outbreak in Southeast Asia, Indonesia has reported record daily cases in seven of the past 11 days, including on Thursday, with 24,836 new infections and 504 deaths, both new highs.

The spike has made it harder to transfer severely ill patients, and city hospitals were at 93% capacity this week. Hospitals across Java are also nearly full.

“We… receive the incoming patients as best as we can. Give them oxygen, check their blood pressure, and observe them,” she said, adding that if a patient’s condition worsens it is unlikely that other hospitals can take them.

“The worst case is they die here. I definitely feel sad even if I have seen… people dying many times,” said Cheras.

She is working 12-hour shifts, double the normal length, after she said some of her colleagues were infected despite being fully vaccinated.

Indonesian authorities have announced new curbs starting Saturday, including tighter restrictions on movement and air travel, a ban on restaurant dining and closing non-essential offices.

Still, despite the huge strain and concerns she could be re-infected with COVID-19, Cheras tries to remains positive.

“Although we are exhausted and wonder when will this end… I think it still manageable,” she said.

(Writing by Ed Davies. Editing by Gerry Doyle)

White House sending special teams to COVID-19 hot spots to combat Delta variant

By Andrea Shalal and Carl O’Donnell

WASHINGTON (Reuters) – The White House on Thursday said it would send out special teams to hot spots around the United States to combat the highly contagious Delta coronavirus variant, and urgently called on Americans who have not been vaccinated to get shots.

White House COVID-19 senior adviser Jeffrey Zients told reporters the “surge response” teams would be ready to speed additional testing supplies and therapeutics to communities that were experiencing increases in COVID-19 cases.

The seven-day-average number of COVID-19 cases in the United States has risen 10% since last week, U.S. Centers for Disease Control and Prevention Director (CDC) Rochelle Walensky said on a Tuesday press call.

The more easily transmitted Delta variant, which was first detected in India, is thought to have become the second most prevalent coronavirus variant in the United States, she added.

“It is clear that communities where people remain unvaccinated are communities that remain vulnerable,” Walensky said, adding that 1,000 counties in the United States have vaccination rates below 30%.

Zients said federal personnel will assist communities with public health staffing and the CDC will provide assistance in containing potential outbreaks.

The United States remains a world leader in COVID-19 vaccinations, with more than 180 million Americans having received at least one shot.

(Reporting by Lisa Lambert, Carl O’Donnell and Andrea Shalal; Editing by Jonathan Oatis and Bill Berkrot)

Factbox: Latest on the worldwide spread of the coronavirus

(Reuters) – The Euro 2020 soccer tournament was blamed for a surge in cases as fans have flocked to stadiums, bars and spectator zones across Europe to watch the action while the pandemic still raged.

DEATHS AND INFECTIONS

EUROPE

* Europe’s drug regulator said the vaccines approved in the European Union offered protection against all coronavirus variants, including Delta, but called for active monitoring by vaccine manufacturers to stay alert.

* Prime Minister Boris Johnson said he was confident Britons fully vaccinated against COVID-19 would be able to travel abroad this year.

* A 10-week decline in new infections across Europe has come to an end and a new wave of infections is inevitable if citizens and lawmakers do not remain disciplined, the head of WHO in Europe, Hans Kluge, told a news briefing.

ASIA-PACIFIC

* President Joko Widodo said that Indonesia will impose emergency measures until July 20 to contain an exponential spike in cases that has strained the medical system.

* Japan is considering an extension of two weeks to a month for coronavirus prevention measures in Tokyo and other areas, Japanese media said.

AMERICAS

* Bolivia’s government is looking to stabilize the country’s economy, which last year plunged the most in over half a century, with a mix of fiscal spending, vaccines and gold.

* Dominican health authorities will on Thursday begin distributing a third dose of vaccine in an effort to protect against more contagious new variants.

MIDDLE EAST AND AFRICA

* The United States will begin shipping the first batch of vaccines it has donated to Africa from this weekend, a special envoy of the African Union said, as the continent sees a surge in cases fueled by variants.

* The South African Medical Association threatened to take the government to court because scores of new junior doctors cannot find work placements despite staff shortages during the pandemic.

* Police in Uganda have arrested two nurses and were hunting for a man who had posed as a doctor to sell and administer fake vaccines to hundreds of people, authorities said, amid a rising second wave of infections.

MEDICAL DEVELOPMENTS

* Indian drugmaker Zydus Cadila said it has applied for emergency use approval of its three-dose vaccine that showed efficacy of 66.6% in an interim study and could become the second home-grown shot if regulators consent.

* CureVac said its COVID-19 vaccine was 48% effective in the final analysis of its pivotal mass trial, only marginally better than the 47% reported after an initial read-out two weeks ago.

ECONOMIC IMPACT

* Global stock markets rose on strong European and U.S. shares on Thursday, with stocks brushing off a rapid re-acceleration in coronavirus cases and oil and the dollar extending their first-half rallies.

* Mexico’s factories deteriorated for a 16th straight month in June amid the ongoing COVID-19 crisis and local restrictions, though the pace of contraction was the slowest since the effects of the pandemic first hit Mexico, a survey showed.

* Turkey’s pandemic-era ban on layoffs and a government wage support system, both adopted in early 2020, expired as most remaining restrictions were also lifted, setting the stage for a rise in unemployment.

* The IMF’s executive board approved the second review of Jordan’s four-year reform program and commended it for meeting its fiscal targets despite the fallout from the coronavirus, the finance ministry said.

(Compiled by Federico Maccioni, Amy Caren Daniel and Jagoda Darlak; Edited William Maclean)

COVID-19 cases worsen in Latin America, no end in sight – health agency

By Anthony Boadle

BRASILIA (Reuters) -Cases of COVID-19 may be declining in North America but in most of Latin America and the Caribbean the end to the coronavirus pandemic “remains a distant future,” the Pan American Health Organization (PAHO) said on Wednesday.

While infections in the United States, Canada and Mexico are falling, in Latin America and the Caribbean cases are rising and vaccination is lagging badly. Only one in ten people have been fully vaccinated, which PAHO director Carissa Etienne called “an unacceptable situation.”

“While we are seeing some reprieve from the virus in countries in the Northern Hemisphere, for most countries in our region, the end remains a distant future,” she said.

Noting that the hurricane season in the Caribbean is arriving at a time when outbreaks are worsening, Etienne urged countries to outfit hospitals and expand shelters to reduce the potential for transmission. Social distancing and proper ventilation become difficult during storms, she said.

The highly transmissible Delta variant has already been detected in a dozen countries in the Americas, but so far community transmission has been limited, said PAHO viral disease advisor Jairo Mendez.

However, it has been found in Argentina, Brazil, Canada, Chile, Peru, the United States and Mexico, where it has spread in Mexico City, according to PAHO.

Given the presence of such variants, countries in the region should step up vigilance and consider the need to limit travel or even close borders, PAHO health emergencies director Ciro Ugarte said.

According to a Reuters tally, there have been at least 37,441,000 reported infections and 1,272,000 confirmed deaths caused by COVID-19 in Latin America and the Caribbean so far, one third more than in Asia and Africa combined.

(Reporting by Anthony BoadleEditing by Sonya Hepinstall)