Belgian university city hopes circles will encourage social distancing

By Bart Biesemans

GHENT, Belgium (Reuters) – The Belgian city of Ghent has struggled to persuade its large student population to stick to social distancing rules during the pandemic, but the authorities hope they have found a solution at least to keep outside gatherings under control.

The city, home to some 80,000 students, has painted 100 large, white circles on the ground in St Peter’s Square at the heart of the student district, and in nearby parks over the past month, an effort reinforced after partying there last week led to clashes with police.

Ghent mayor Mathias De Clercq said the students themselves had come up with the idea, but stressed that, while Belgian COVID rules limit groups meeting outdoors to four people, it was not mandatory for a group to sit in a circle.

“Everyone is free to use them or not,” he told Reuters television. “It’s a nice example of nudging, a gentle push towards good behavior.”

The circles are 6 meters (19 feet 8 inches) in diameter and 4 meters apart.

Students seemed reasonably content with the system as they sat out in the sunshine this week.

“In these harsh times, it’s not very easy to meet people and to socialize with your friends. So I think it’s a good solution. It looks a little bit weird, but it’s effective,” said 20-year-old engineering student Elian Colpaert.

Law student Kato Pion said some had complained the authorities were treating them like infants, but thought the circles were a good idea.

“But I think it is actually good that we are given the freedom to sit on the square, of course according to the rules,” she said.

(Writing by Philip Blenkinsop; Editing by Raissa Kasolowsky)

Immune response may be linked to AstraZeneca vaccine clot issue; death risk rising among young adults in Brazil

By Nancy Lapid

(Reuters) -The following is a roundup of some of the latest scientific studies on the novel coronavirus and efforts to find treatments and vaccines for COVID-19, the illness caused by the virus.

Immune response may explain rare clots after AstraZeneca vaccine

Researchers may have found an explanation for the rare but serious blood clots reported among some people who received AstraZeneca’s COVID-19 vaccine. They believe the phenomenon is similar to one that rarely occurs with a blood thinning drug called heparin, called heparin-induced thrombocytopenia (HIT). In HIT, the drug triggers the immune system to produce antibodies that activate platelets, which cause blood to clot. Drugs other than heparin can cause clotting disorders that strongly resemble HIT, and researchers suspect that in rare cases, the AstraZeneca vaccine may be another such trigger. Four previously healthy individuals who got the AstraZeneca shot and developed life-threatening clots had the same kind of antibodies that activate platelets and initiate clotting in HIT, the researchers reported on Monday in a paper posted on Research Square ahead of peer review. Twenty individuals who received the vaccine but did not develop clots did not have these antibodies. An editorial comment posted with the study noted that drug-induced thrombocytopenia is treatable if identified promptly. Millions of people have received the vaccine without issues and European regulators and the World Health Organization say the benefits of the AstraZeneca shot outweigh its risks.

COVID-19 death risk rising for young adults in Brazil

Southern Brazil is seeing a sudden rise in COVID-19 deaths among young and middle-aged adults after the identification there of a concerning virus variant known as P.1, researchers said. They analyzed data from Parana – the largest state in southern Brazil – on 553,518 cases diagnosed from September 2020 through March 17, 2021. In all age groups, the proportion of patients who died either held steady or declined between September and January. Starting in February, however, fatality rates rose for almost all groups over age 20, according to a report posted on Friday on medRxiv ahead of peer review. From January to February, these rates tripled among patients aged 20 to 29, from 0.04% to 0.13%, and doubled among those aged 30 to 39, 40 to 49, and 50 to 59. “Individuals between 20 and 29 years of age whose diagnosis was made in February 2021 had an over 3-fold higher risk of death compared to those diagnosed in January 2021,” the researchers said. “Taken together, these preliminary findings suggest significant increases in case fatality rates in young and middle-aged adults after identification of a novel SARS-CoV-2 strain circulating in Brazil, and this should raise public health alarms.”

Pfizer, Moderna vaccines limit asymptomatic infections

Vaccines from Pfizer Inc and partner BioNTech SE and from Moderna Inc dramatically reduced the risk of infection by the new coronavirus within weeks after the first of two shots, according to data from a study of nearly 4,000 U.S. healthcare personnel and first responders in six states. Previous trials by the companies evaluated the vaccines’ efficacy in preventing illness from COVID-19, but would have missed infections that did not cause symptoms. In the new study, conducted from mid-December to mid-March, nearly 75% of participants had received at least one dose of vaccine, and everyone had weekly coronavirus testing for 13 consecutive weeks in order to pick up asymptomatic infections. According to a report published on Monday by the U.S. Centers for Disease Control and Prevention (CDC), the risk of infection fell by 80% two weeks or more after the first of two shots and by 90% by two weeks after the second shot. “The authorized mRNA COVID-19 vaccines provided early, substantial real-world protection against infection for our nation’s healthcare personnel, first responders, and other frontline essential workers,” CDC Director Rochelle Walensky said in a statement.

Pandemic has cut parents’ access to hospitalized children

Pediatricians have long endorsed the idea that babies and children in hospitals should not be separated from their families – a practice that in many facilities was restricted or discontinued to limit COVID-19 infections, according to new research. From mid-May through early July, researchers collected survey responses from 96 pediatric care units in 22 countries in Europe, Asia, and North America. The results – mostly from intensive care units for newborns – showed that before the pandemic, 87% of units welcomed families and 92% encouraged skin-to-skin care, according to a report published in Journal of Perinatology. After the onset of the pandemic, more than 83% of the hospital units restricted family presence, with additional restrictions placed on parental participation in their infant’s care, said study coauthor Ita Litmanovitz of Meir Medical Center in Kfar Saba, Israel. Hospitals’ decisions to limit family access did not depend on their previous rules, the availability of single-family rooms, or the virus infection rate in the hospital’s geographical area. “Restrictions during the pandemic increased separation between the infant and family,” the researchers found. These restrictions, Litmanovitz added, “go against psychological and neuroscientific evidence in support of unrestricted parental presence and ability to care for their hospitalized infants.”

(Reporting by Nancy Lapid; Editing by Bill Berkrot)

Philippines sees 10,000 new COVID-19 cases as tight curbs return to capital

By Neil Jerome Morales

MANILA (Reuters) – The Philippines passed the 10,000 mark for new daily coronavirus infections for the first time on Monday and put its capital region back on one of its toughest levels of lockdown, to try to tackle a spike in cases that is testing its healthcare capacity.

Manila and surrounding provinces were put back under enhanced community quarantine (ECQ), the highest tier in its containment protocols, for the first time since May 2020 to try to quell the surge in cases, despite inroads late last year towards controlling its epidemic.

The country recorded 10,016 new infections on Monday, bringing the overall tally to 731,894, with deaths at 13,186, one of the highest caseloads in Asia.

Health experts say the surge in infections underscores the need to expedite a national vaccination drive, with only 656,331 healthcare workers so far given their first of two shots. The government aims to inoculate 70 million people this year.

It has also struggled to secure vaccine supplies, with an inventory of 2.525 million doses, mostly of Sinovac Biotech’s vaccine, one million of which arrived on Monday.

Philippines President Rodrigo Duterte on Monday allowed the private sector to import vaccines to boost supply and help reopen the economy.

“Whatever the cost, whatever the volume they want to bring in, it’s fine with me,” Duterte said in a national address.

Prior to Duterte’s approval, businesses go through the government for supply deals. Previously, half of the purchased doses were required to be given to the government.

Health authorities blame the spike on poor public compliance with prevention measures and the presence of new and more transmissible coronavirus variants in the capital region, which accounts for about a third of economic activity.

“This surge is really challenging while ECQ is painful, particularly for the economic sector,” said Benjamin Co, an infectious disease expert with three Manila hospitals.

The Philippines was the first country in Asia to go under a nationwide lockdown and broad restrictions and movement curbs saw its economy slump 9.5% last year, its worst economic contraction on record.

Hospitals’ intensive care and isolation bed capacity in the capital region have reached critical levels or above 70% usage, government data showed.

“I can give you beds, I can give you rooms. The problem is I cannot give you additional manpower capacity, like nurses and doctors to take care of you,” Co added.

(Reporting by Neil Jerome Morales; Editing by Ed Davies and Marguerita Choy)

More under-30 Americans report anxiety, depression during pandemic – CDC

By Vishwadha Chander

(Reuters) – More young adults in the United States reported feeling anxious or depressed during the past six months of the COVID-19 pandemic, and fewer people reported getting the help they needed, according to a U.S. government study released on Friday.

The percentage of adults under age 30 with recent symptoms of an anxiety or a depressive disorder rose significantly about five months after the U.S. imposed COVID-19 related lockdowns, and reported rising deaths from the fast-spreading virus.

Between August 2020 and February 2021, this number went up to 41.5% from 36.4%, as did the percentage of such people reporting that they needed, but did not receive, mental health counseling.

The study suggests that the rise in anxiety or depressive disorder symptoms reported correspond with the weekly number of reported COVID-19 cases.

The findings are based on a Household Pulse Survey conducted by the U.S. Centers for Disease Control and Prevention (CDC) and the Census Bureau to monitor changes in mental health status and access to care during the pandemic.

“Trends in mental health can be used to evaluate the impact of strategies addressing adult mental health status and care during the pandemic, “the authors of the study wrote in the CDC’s Morbidity and Mortality Weekly Report released on Friday.

The study also found those with less than a high school education were more at risk, though it did not provide an explanation for it.

Even with more vaccines gaining authorization beginning late 2020, the effects of the pandemic on mental health continued into 2021.

During Jan. 20, 2021 through Feb. 1, 2021, about two in five adults aged over 18 years experienced recent symptoms of an anxiety or a depressive disorder, the survey found.

Demand for mental health and meditation apps, and investments in tech startups building these apps have also risen during this period.

(Reporting by Vishwadha Chander in Bengaluru; Editing by Caroline Humer and Shailesh Kuber)

Dying in line: Brazil’s crunch for COVID-19 intensive care beds

By Stephen Eisenhammer

PIRATININGA, Brazil (Reuters) – José Roberto Inácio spent much of his life ferrying the sick and injured to the hospital in this quiet Brazilian town.

On Wednesday, March 10, the retired ambulance driver took the familiar route once more – as a passenger gasping for breath.

By the weekend, the 63-year-old’s kidneys were failing. He needed dialysis. He needed intensive care.

But at the small hospital where he was being treated even basic medical supplies, like a catheter, were lacking. He joined the list for a bed in an intensive care unit (ICU), but doctors told his family there were 70 people in this part of Sao Paulo state already in line.

Bauru, the nearest major town, only has 50 intensive care beds – and all were full.

Inácio died waiting.

“All his life he worked to save people, but in the hour that he needed help, there was nothing for him,” Inácio’s son Roberto, 41, told Reuters, eyes still blank with shock. “You watch a person dying, and you can’t do anything about it.”

Inácio was one of 3,251 people in Brazil killed by COVID-19 on March 23, then the highest daily death toll since the pandemic began. Around the world, nearly one in three COVID-19 deaths were Brazilian. Inácio was one.

“He’s become a statistic,” his son said.

As much of the world appears to be emerging from the worst of the pandemic, Brazil’s health system is buckling.

Across the country there are over 6,000 people waiting for an ICU bed, according to government data. In 15 of Brazil’s 26 states, ICU capacity is at or above 90% full, as the country’s P1 variant fuels a second wave far deadlier than the first.

Even in Sao Paulo, Brazil’s wealthiest state with a sophisticated public hospital network, scores are dying in line for intensive care.

Despite the crisis, President Jair Bolsonaro continues to ridicule stay-at-home measures. He rarely wears a mask and has said he does not plan to get vaccinated. He told Brazilians to “stop whining” about the number of dead, now over 300,000 – the world’s second-highest toll behind the United States.

Brazil, a major global economy once lauded for its public health victories, has also been slow to secure vaccines for its 210 million inhabitants. Less than 10% of adults have received a first dose and only 3% are fully vaccinated.

Epidemiologists fear the worst is yet to come.

“This is going to be devastating,” said Albert Ko, a professor at Yale School of Public Health with decades of experience in Brazil. “Unless there’s a change in federal and state government policies, towards implementing effective lockdowns, we’re looking at a real humanitarian crisis.”

SILENT BURIAL

A giant billboard of Bolsonaro greets visitors to Bauru, a town of 400,000 about a four-hour drive from Sao Paulo.

The mayor, Suéllen Rosim, has railed against lockdown measures and aligned herself with the far-right leader. Last month, she defied a state government order to close nonessential businesses, allowing many to remain open despite surging COVID-19 cases.

A court ruling finally forced her to comply, but she continues to argue lockdowns are ineffective despite overwhelming evidence they have worked across the globe.

“There’s no science that shows that if I lock everyone up at home, everything will get better,” she told Reuters. “Bars and restaurants have been shut for weeks and the numbers haven’t stopped going up.”

She blamed the state for a lack of ICU capacity.

In response, the Sao Paulo government said it was working to increase the number of hospital beds in Bauru and across the region. The state criticized the municipality, which it said did not fund a single intensive care bed.

“The town is also responsible for the increase of intensive care and should do its part,” the state said in a note to Reuters.

On Bauru’s front line, doctors are exhausted; understaffed and under-resourced against the relentless tide of infections.

“People have been talking for months about the risk of the public health system collapsing,” said Fred Nicácio, a doctor treating COVID-19 patients in Bauru. “Sadly, that moment has come.”

Ambulances dart across town carrying patients connected to green oxygen canisters, their belongings in black trash bags by their feet.

One patient in his 40’s, between concentrated breaths, said he now understood the virus was no joke, as medics wheeled him into the hospital.

Beds are so scarce in Bauru that desperate relatives are turning to the courts, hiring lawyers to secure injunctions that would force hospitals – public or private – to take in patients.

But lawyers cannot create ICU beds where there are none. Even private hospitals are struggling, sometimes begging the public sector to take patients needing intensive care off their waitlists.

Inácio’s son is haunted by the belief that his father’s death could have been avoided. If a vaccine had reached him in time, if his hospital had an extra catheter, if an ICU bed had become available.

Last Wednesday, one week after entering the hospital he knew so well, Inácio was buried.

Four men in white hazmat suits drove his body in a minivan the two blocks to the cemetery. They carted the wooden coffin between the rows of dead to a break in the red dirt.

No words were spoken. The only sound was the scratching of mortar and brick as the tomb was sealed.

From a distance, his son watched.

(Reporting by Stephen Eisenhammer; Additional reporting by Leonardo Benassatto; Editing by Brad Haynes and Jonathan Oatis)

WHO says COVID-19 probably passed from bats to humans through another animal: AP

(Reuters) – A joint WHO-China study on the origins of COVID-19 says that the virus was probably transmitted from bats to humans through another animal, and that a lab leak was “extremely unlikely” as a cause, the Associated Press reported on Monday.

The reported findings match what WHO officials have said in the past about their conclusions following a Jan-Feb visit to China.

Many questions remain unanswered, and the team proposed further research in every area except the lab leak hypothesis, the Associated Press reported, citing a draft copy it had obtained.

WHO director-general Tedros Adhanom Ghebreysus acknowledged receipt of the report from the independent experts but declined to give details, telling a Geneva news briefing: “All hypotheses are on the table and warrant complete and further studies.”

The 400-page report, drawn up by the team which carried out a mission to the central Chinese city of Wuhan where the virus was first encountered in late 2019, is to be issued on Tuesday after diplomats from WHO’s 194 member states are briefed on its findings, Tedros said.

Germany’s international development minister Gerd Mueller, speaking to the same briefing after holding talks with Tedros, welcomed China’s cooperation with the probe.

The United States expects the WHO-led investigation to require further study of the SARS-CoV-2 virus, perhaps including a return visit to China, a senior U.S. official told reporters last week. He hoped it would be “based on science”.

The probe was plagued by delays, concern over access and bickering between Beijing and Washington, which under former U.S. President Donald Trump’s administration accused China of hiding the extent of the initial outbreak.

(Reporting by Nandakumar D in Bengaluru and Stephanie Nebehay and Emma Farge in Geneva; Editing by Himani Sarkar and Peter Graff)

Mourners make Prague’s Old Town Square into somber memorial for coronavirus victims

By Jiri Skacel

PRAGUE (Reuters) – Prague residents laying flowers, scribbling names or mourning quietly have turned the Czech capital’s medieval Old Town Square into an improvised memorial to the thousands of lives lost to the COVID-19 pandemic in the past year.

A civic group called “Million Moments for Democracy” sprayed 25,000 white crosses overnight on Monday on the cobble-stoned square, surrounded by gothic and baroque churches and Prague’s famed Astronomical Clock, to commemorate victims of the pandemic in the past year — and blame the government for missteps.

The plan was to wash the crosses off that day, but Prague’s city hall said it would let them stay until rain washes them off.

Then people spontaneously started chalking names, dates of deaths and notes to individual crosses, turning the original act into personal commemorations.

Anna Vojtechova brought a flower and a small bottle of the Czech herbal liqueur Becherovka for her brother, who died aged 75 on March 1, the same day he registered for vaccination.

“He was supposed to be vaccinated and did not live to see it. He was healthy, not obese, no illness. It chewed him up. People must be hugely careful,” she said while fighting tears.

Another mourner, Petr Popov, came to remember a friend from Prague’s Bulgarian community. “I want to write his name down with chalk to pay respects,” he said.

Others, who have not been personally hit, also visit.

Monika Mudranincova said she wanted to pay her respects.

“We feel so sorry and it would be amazing if we saw a light at the end of the tunnel, but it seems there is none yet,” she said.

During the first wave of the pandemic, a year ago, the Czech government quickly shut borders, schools and retail outlets, leading the country through with minimum losses. But it was also quick to relax restrictions after the first wave and slow to build up testing and tracing capacities over the summer.

The government reacted slowly to a new surge in infections in the autumn. Another relaxation before Christmas and the spread of the more infectious British variant of the virus packed hospitals again in January and then March.

Now the central European country of 10.7 million has become one of the world’s worst-hit in the pandemic, reporting over 1.5 million coronavirus infections and 25,639 deaths, and thousands more excess deaths above normal rates.

The death toll is the highest per capita in the world apart from San Marino, according to Our World in Data website.

(Reporting by Jiri Skacel, writing by Jan Lopatka, editing by Larry King)

‘No light at the end of the tunnel’ – The COVID-19 battle in one French hospital

By Pascal ROSSIGNOL

CAMBRAI, France (Reuters) – Anesthetist Caroline Tesse cannot say whether the third wave of COVID-19 infections sweeping across France will peak in three weeks or three months. But she does know that it is too late to prevent the virus from overwhelming her intensive care unit.

All bar one of the ward’s 22 beds is occupied by a COVID-19 patient. The moment a bed is freed, another gravely ill patient is wheeled in – and as the B.1.1.7 variant, first detected in Britain, tightens its grip, they are arriving younger and sicker.

“What’s difficult is not having any light at the end of the tunnel,” said Tesse, a 35-year-old mother-of-three for whom the intensity of the latest surge in coronavirus infections is taking a toll at home and in the workplace.

Cambrai in northern France lies in one of the hardest hit areas of the country. Some 450 in every 100,000 people are testing positive and the rate is climbing.

On the ICU ward, the pace is relentless. Adryen Bisiau, a doctor on Tesse’s unit, described the latest spike as “the toughest wave we’ve endured so far”.

President Emmanuel Macron tightened COVID-19 restrictions in much of northern France and the Paris region a week ago, but he stopped short of a full lockdown that many hospitals had been calling for.

Strict confinements and school closures should be an act of last resort, Macron and his government say. But on the front line in the battle to save lives, that moment has for many passed.

“I don’t think the latest measures can stem the spread,” Tesse said after a delicate procedure to intubate yet another patient. “It’s too late.”

“We can’t even tell how long this wave will last.”

After a European Union summit at which leaders agreed to stricter export controls on vaccines, Macron on Thursday defended his decision not to impose a third lockdown as early as January.

“I have no mea culpa to make, no regrets,” the president said.

(Reporting by Pascal Rossignol; Writing by Richard Lough; Editing by Janet Lawrence)

EU export restrictions on COVID shots would be ‘lose-lose’ situation: Pfizer executive

By John Miller

ZURICH (Reuters) – European Union export restrictions on COVID-19 vaccines would result in a ‘lose-lose’ situation for everyone, including EU members, a Pfizer executive said, a day after the bloc tightened oversight of shot deliveries beyond its borders.

The EU’s action would give it greater scope to block shipments to countries with higher inoculation rates such as Britain, or which are not sharing doses that they produce.

The specter of export restrictions has many concerned, given the global nature of vaccine production, in which shots have hundreds of ingredients sourced in dozens of countries. New roadblocks for shots or raw materials could disrupt pandemic-fighting efforts as the world struggles to contain a third wave of infections, companies fear.

“We have observed these recent developments with concern,” Sabine Bruckner, Swiss country manager for Pfizer, said at a Swiss government press conference on Thursday.

“Our executive leadership has been in direct contact with the European Union. Our position has been laid out, we are very critical, we can’t support it at all,” she added.

“Should it really come to export restrictions, that would be a ‘lose-lose’ situation for everyone, also for the members of the European Union.”

The new rules set out by the European Commission, which oversees EU trade policy, expand existing measures aimed at ensuring planned exports by drugmakers do not threaten the bloc’s supply.

They add 17 previously exempt countries including Israel, Norway and Switzerland to the list of countries for which exports of EU-produced vaccines require licenses. Switzerland, for instance, gets its Pfizer COVID-19 shots from a plant in Belgium.

Pfizer’s Bruckner made the comments after a Swiss vaccine summit in which Health Minister Alain Berset predicted his country would receive 10.5 million vaccines from suppliers including Pfizer and Moderna by July, enough to vaccinate everybody in Switzerland who wants a shot, he said.

(Reporting by John Miller in Zurich and Philip Blenkinsop in Brussels; Editing by Elaine Hardcastle)

Polish hospitals under strain as coronavirus cases hit 2021 record

WARSAW (Reuters) – Poland reported a record number of new coronavirus cases on Wednesday just shy of 30,000, as the pandemic cripples hospitals in some parts of the country and the government mulls sending patients to different regions to help cope.

Poland has been hit very hard by a third wave of cases and a highly contagious variant of the virus first discovered in Britain. The regions of Silesia in the south and Mazowiecki, where the capital Warsaw is located, in particular have struggled.

The government has faced criticism for failing to support the healthcare system as cases rise, while it has called on the public to observe current restrictions more closely.

“Poland’s eyes are focused on Silesia,” Health Minister Adam Niedzielski said on Wednesday, adding that the government was considering moving patients from the south to the east, where more beds are available.

In Silesia, Tuesday data showed that of 305 available respirators, 257 were occupied, while 2,894 of 3,723 hospital beds were occupied.

Doctors said the whole country’s healthcare system was struggling, however.

“We are lacking beds everywhere, let’s not fool ourselves. This is an all-Poland situation,” immunologist Pawel Grzesiowski told Reuters.

On Wednesday the number of occupied beds rose to 26,511 from 26,075, while occupied ventilators rose edged up to 2,537. The ministry said it has 35,444 hospital beds available for COVID-19 patients and 3,366 ventilators.

Poland reported 29,978 new infections on Wednesday and 575 daily coronavirus-related deaths, a record in 2021.

The country has reported 2.12 million confirmed cases overall and 50,340 deaths.

The government ordered theatres, shopping malls, hotels and cinemas to close last week as cases rose.

More restrictions loom ahead of the Easter holidays, typically marked by packed church services and family gatherings in the deeply Catholic country.

“We have to suffocate the third wave. That’s why we will announce new restrictions…that will be enforced during the week before and the week after the (Easter) holidays,” Prime Minister Mateusz Morawiecki told a news conference on Wednesday.

Those restrictions are expected to be announced on Thursday.

(Reporting by Agnieszka Barteczko, Joanna Plucinska, Alicja Ptak and Pawel Florkiewicz; Editing by Andrew Heavens and Hugh Lawson)