Vaccinating adults appears to protect children around them; bar opening event linked to 46 COVID-19 cases

By Nancy Lapid

(Reuters) – The following is a roundup of some of the latest scientific studies on the novel coronavirus and efforts to find treatments and vaccines for COVID-19, the illness caused by the virus.

Vaccinating adults appears to protect children as well

New data from Israel, where health officials moved quickly to distribute the COVID-19 vaccine from Pfizer Inc and partner BioNTech SE, suggests that the vaccination of adults also protects unvaccinated people living around them. Roughly one third of Maccabi Healthcare Services (MHS) 1.95 million members – all above the age of 16 – had received at least a single vaccine dose by Jan. 30. In analyzing outcomes in 223 communities, researchers found that as the number of vaccinated adults went up, infection rates among unvaccinated MHS members in the same community went down – particularly among children. MHS is Israel’s second largest healthcare maintenance organization. “While the observed vaccine-associated protection of unvaccinated is encouraging, further studies are required to understand whether and how it might support the prospect of herd immunity and disease eradication,” the researchers concluded in the study posted on Wednesday on medRxiv ahead of peer review.

Illinois bar-opening event linked to 46 cases of COVID-19

An indoor celebration of a bar opening in rural Illinois in February led to 46 new cases of COVID-19 and wider ramifications, according to a U.S. study that serves as a caution about how such events can affect local communities. Four attendees had COVID-19-like symptoms that day. Of the 46 coronavirus infections linked to the party, there were 26 cases among patrons, three in staff members and 17 “secondary cases” in people infected by them, according to a report published on Monday in the Morbidity and Mortality Weekly Report from the U.S. Centers for Disease Control and Prevention. The secondary cases included children and residents of long-term care facilities. “Transmission associated with the opening event resulted in one school closure affecting 650 children (9,100 lost person-days of school) and hospitalization of one long-term care facility resident with COVID-19,” researchers said. “These findings demonstrate that opening up settings such as bars, where mask wearing and physical distancing are challenging, can increase the risk for community transmission of SARS-CoV-2,” researchers said. Businesses should “work with local health officials to promote behaviors and maintain environments that reduce the risk for SARS-CoV-2 transmission and develop strategies for reopening safely to prevent outbreaks in the community, such as modifying layouts and operating procedures,” they said.

Congenital heart disease does not worsen COVID-19 risks

Adults with congenital heart defects are not more likely than the average person to have severe COVID-19, or to die from it, according to an international study. Risk factors associated with poor outcomes in these individuals are the same as those associated with poor outcomes in the general public – older age, male gender, a history of heart failure, irregular heart rhythm, kidney problems, diabetes, and need for extra oxygen before becoming infected with the coronavirus, said study coauthor Dr. Jamil Aboulhosn of the UCLA Adult Congenital Heart Center. Researchers analyzed data from 1,044 adults with COVID-19 from 58 congenital heart disease centers worldwide. Even people with very complex heart defects did not appear to have an increased risk of severe COVID-19 as long as they did not already have severe signs and symptoms of heart disease, Aboulhosn said, calling the finding, “somewhat surprising.” The study was published in the Journal of the American College of Cardiology.

Stroke patients with COVID-19 have worse outcomes

Among patients who went to a hospital because they were having a stroke, those who tested positive for COVID-19 had higher odds of dying there, a new study shows. The patients with COVID-19 were also more likely to have more severe stroke and to suffer another stroke while hospitalized, researchers reported in the journal Stroke. They studied close to 42,000 patients who arrived at 458 hospitals with ischemic stroke, caused by blockages in arteries that carry blood to the brain. About 3% of the patients tested positive for COVID-19. On average, they got to the hospital as quickly as patients without coronavirus infection. After that, things slowed down. “Likely due to the need for personal protective equipment use and other precautions” by hospital staffers, it took longer for COVID-19 patients to get clot-busting treatments that reopen the clogged vessels, said study coauthor Dr. Gregg Fonarow of the University of California, Los Angeles. The study cannot prove that treatment delays caused the worse outcomes. However, Fonarow said, “these findings suggest there is a need to further enhance stroke protocols to provide more timely diagnosis and treatment for patients with (ischemic stroke) to speed care while still protecting healthcare workers from exposure.”

(Reporting by Nancy Lapid, Marilynn Larkin and Megan Brooks; Editing by Bill Berkrot)

U.S. COVID-19 cases rise for third straight week, hospitalizations also up

(Reuters) – New cases of COVID-19 in the United States rose 5% to more than 450,000 last week, the third week in a row that infections have increased, according to a Reuters analysis of state and county data.

The average number of COVID-19 patients in hospitals rose 4% to more than 37,000 in the week ended April 4, breaking a streak of 11 weeks of falling admissions.

Health officials have expressed concerns about the increase in travel around the Easter holiday and school spring breaks, at a time when more infectious variants of the coronavirus are circulating.

While flu viruses tend to be seasonal, with cases falling as the weather warms, health officials said they have not seen similar trends with the novel coronavirus, pointing to a surge in COVID-19 cases in some regions last summer.

“I don’t think we should even think about relying on the weather to bail us out of anything we’re in right now,” Dr. Anthony Fauci, the nation’s top infectious disease expert, said at a news briefing on Monday.

Twenty-seven out of 50 states reported increases in new cases last week compared with the previous seven days, according to the Reuters analysis.

Per 100,000 people, Michigan, New Jersey and New York reported both the highest number of new cases and the highest number of hospitalizations.

Deaths from COVID-19, which tend to lag infections by several weeks, fell 17% to about 5,800 last week, or about 834 per day. Health officials have said the country’s vaccination effort could limit deaths even with rising cases.

For a sixth week, vaccinations set a record, with an average of 3.1 million shots given per day last week. As of Sunday, 32% of the U.S. population has received at least one dose and 19% was fully vaccinated, according to the CDC.

(Graphic by Chris Canipe, writing by Lisa Shumaker, editing by Tiffany Wu)

India’s daily virus cases breach 100,000; mutants, behavior blamed

By Neha Arora and Rama Venkat

NEW DELHI (Reuters) -India reported a record rise in COVID-19 infections on Monday, becoming the second country after the United States to post more than 100,000 new cases in a day, as politicians stage massive election rallies raising fears of further spreading the virus.

Hospitals in the worst affected state, Maharashtra, are being overrun by patients. India’s richest state, home to its commercial capital Mumbai and numerous industries, reported a record 57,074 new cases overnight.

The country’s daily infections have risen about 12 fold since hitting a multi-month low in early February, when authorities eased most restrictions and people largely stopped wearing masks and following social distancing.

With 103,558 new infections, India has now reported 12.6 million cases, the highest after the United States and Brazil, data from the health ministry showed. Deaths jumped by 478, still one of the lowest fatality rates in the world, raising the total to 165,101.

India has recorded the most number of infections in the past week anywhere in the world. More infectious variants of the virus may have played a role in the second surge, some epidemiologists say.

“The new variant, or variants of concern, probably explains a lot of it, rather than simplistic explanation of behavior,” said Rajib Dasgupta, head of the Center of Social Medicine & Community Health in New Delhi’s Jawaharlal Nehru University.

India has found hundreds of cases of the virus variants first detected in the United Kingdom, South Africa and Brazil.

Subhash Salunke, a former WHO official who advises Maharashtra on its COVID-19 strategy, said cases in the state would continue to rise for another couple of weeks. He said a way out was vaccinating all adults in its hardest-hit cities such as Mumbai, Pune and Nashik.

“If we start doing this, by the end of April we will see a downward trend,” he said.

VACCINE RAMP-UP

India, the world’s biggest maker of vaccines, has injected 77 million doses at home since starting its campaign in the middle of January – the third highest after the United States and China.

India’s per capita COVID-19 vaccinations, however, are lower than many other countries, including that of more populated China that started giving shots to its citizens much earlier.

India is currently vaccinating only people above the age of 45, having covered health and front-line workers first with the AstraZeneca shot and a government-backed one.

In a meeting held by Indian Prime Minister Narendra Modi on Sunday, officials discussed raising the country’s vaccine output further. The government has in recent weeks slowed vaccine exports, after shipping more than 65 million doses.

“It was highlighted that all efforts are underway to secure adequate quantities of vaccines to meet the rising domestic requirements as well as to meet the genuine needs of other countries,” his office said in a statement.

Though cases have risen exponentially in nearly a dozen states, politicians and ministers are still addressing election rallies attended by tens of thousands of mask-less people jostling for space.

The health minister in the northeastern state of Assam, currently voting to elect a new government, was ridiculed on social media on the weekend after saying there was no need for masks in his state and that wearing one hurts businesses like beauty parlors.

Maharashtra will start shutting shopping malls, cinemas, bars, restaurants and places of worship from Monday evening. Authorities will also impose a complete lockdown at weekends, as experts worried about a shortage of critical-care beds in hospitals, especially in its smaller cities.

The rise in cases has pulled down the stock market.

(Reporting by Rama Venkat Bengaluru and Neha Arora in New Delhi; Writing by Krishna N. Das; Editing by Himani Sarkar and Michael Perry)

Russia’s COVID-19 death toll as of February crosses 225,000 – stats service

MOSCOW (Reuters) – Russia has recorded over 225,000 deaths related to COVID-19 since the start of the pandemic in April, the Rosstat statistics service said on Friday, a figure that is more than double the death toll cited by the government coronavirus task force.

The statistics, which are reported on a monthly basis and with a lag, covering the period from April 2020 to February 2021, suggest that Russia has the third highest death toll in the world.

At 225,572, the total coronavirus-related death toll places Russia third after the United States, which has reported over 553,000 deaths, and Brazil, with over 325,000, according to data from Johns Hopkins University.

The figure is also more than double the widely-reported rolling death toll provided by the Russian government’s coronavirus task force on a daily basis.

That figure is currently at 99,633 deaths.

The authorities have said in the past that Rosstat’s figures are more complete, including data from autopsy reports not available for the daily tally.

Rosstat also provided monthly data, saying that 29,493 more people died in February this year than during the same month last year.

This marks an increase of 20.6% compared with February 2020, the last month to see no cases of coronavirus reported in Russia.

Of the total number of excess deaths in February, 24,369 were considered linked to the coronavirus, Rosstat said.

Russia recorded its first COVID-19 infection in early March 2020. The total number of cases since then recently crossed the 4.5 million mark.

(Reporting by Gleb Stolyarov; Writing by Polina Ivanova; Editing by Andrew Heavens and Marguerita Choy)

Eerily silent Paris CDG marks Easter without air travel rush

By Tim Hepher and Christian Hartmann

PARIS (Reuters) – Easter at Paris’s Charles de Gaulle airport typically starts two weeks early as extra staff are trained to cope with one of the busiest weekends of the year. On Friday, an eerie calm pervaded Europe’s largest airport as France slides back into lockdown.

Instead of crowded check-ins and relentless take-offs and landings, rows of unused trolleys and redundant queuing barriers greeted visitors to one of the world’s busiest transport hubs.

“It’s nothing like what you would normally see,” said Amor, who has worked at the airport for 20 years, organizing check-in zones and passenger assistance for an airport sub-contractor.

“The airport would be full of people going to Turkey, Greece, Morocco, Tunisia, Egypt for the spring holidays. We handled a Tunisia flight yesterday and there were 80 people,” he said. Air France typically serves Tunis with 150-seat jets.

Charles de Gaulle on Thursday handled 18.1% of the number of passengers seen on the same day in 2019, Aeroports de Paris said.

Adjusting for different dates for Easter, throughput on the few open concourses is closer to 20-25% of a usual Easter.

The enforced lull is more striking given that the airport’s 11 terminals have been condensed into two during the pandemic, though some were already closed for maintenance.

Terminal 2E, usually used by Air France and partners for U.S. flights, is handling all long-range traffic, throwing competing carriers from across the globe into a shared space.

A dedicated check-in zone for business class – worst hit by the coronavirus travel crisis – has been suspended and a large COVID-19 testing area takes up one end of the vast hall.

Europe’s border-free Schengen area is served opposite at 2F.

JOBS AT RISK

Charles de Gaulle airport, built in wheat fields northeast of Paris, has seen explosive growth since the first jumbo touched down from New York in 1974.

Terminal 2 opened in 1982 as a hub for Air France, with its undulating modular design shortening the time from gate to curb.

The original 2B was closed for repairs before the crisis but much of the rest of the Terminal 2 complex has been transformed from a snarl of traffic jams to a bowl of deserted concrete.

The global travel slump has cast a shadow over the local economy where 100,000 people work at Charles de Gaulle, a major employer in the capital’s depressed northern suburbs.

Airport staff say less than half of those people are actively working this Easter, with the rest on furlough or finding that the usual temporary jobs have not materialized.

Up to 30,000 jobs could disappear for good, the deputy head of Paris CDG Alliance, which groups the airport’s largest employers and regional government agencies, told Le Monde newspaper.

That contrasts with crowded scenes observed this week in China and the United States, two fast-recovering markets.

On Thursday, the U.S. screened 1.56 million air travelers, 65% of the comparable 2019 level, official data showed.

In Europe, progress in pushing back a third wave of coronavirus infections has been widely described as patchy. On Wednesday, French President Emmanuel Macron ordered France into its third national lockdown.

With Easter already a wash-out, the airline industry is fretting over bookings for summer. Experts say a second lost summer would threaten more bankruptcies..

The drop in passenger numbers means fewer staff from security to cleaners and wheel-chair attendants. Check-in for one Gulf airline now uses 4 agents per flight rather than 7.

Inconsistent border rules for dealing with the pandemic further complicate the planning.

“For Denmark and Sweden we have to have 5-6 agents to check the paperwork rather than the normal two,” one employee said.

On the airport’s most southerly runway, the morning wave of long-haul jets continued to arrive on Friday from as far away as Buenos Aires, Taipei or Douala. But industry statistics show such international flights are much emptier than usual.

International travel is expected to lag short-haul trips in any eventual recovery, hobbled by a video-conferencing craze.

“Zoom is doing well,” said an airline employee who specializes in looking after premium customers.

Still, some export-dependent companies are beginning to test the water, fearing Russian, Chinese or U.S. competition.

“We have to start moving again and keep doing business,” said Marc Vacher, a production executive at French energy services company Idex, arriving early for a flight to Ukraine.

“You can’t go without face-to-face contact with customers; otherwise, it is harder to catch up later,” he added.

(Additional reporting by Laurence Frost, Tracy Rucinski, David Shepardson; editing by Barbara Lewis)

Turkey’s new daily COVID-19 cases exceed 40,000, highest level yet – ministry

ISTANBUL (Reuters) – Turkey recorded 40,806 new coronavirus cases in the last 24 hours, health ministry data showed on Thursday, the highest level since the beginning of the pandemic.

Cases have surged since the government eased measures to curb the pandemic in early March.

On Monday, President Tayyip Erdogan announced a tightening of measures, including the return of full nationwide weekend lockdowns for the Islamic fasting month of Ramadan, which starts on April 13.

The total number of cases stands at 3.358 million, the data showed. The latest daily death toll was 176, bringing the cumulative toll to 31,713.

(Reporting by Daren Butler;Editing by Elaine Hardcastle)

COVID pandemic increased stillbirth and maternal death rates, study shows

(Reuters) – Rates of stillbirth and maternal deaths rose by around a third during the COVID-19 pandemic, with pregnancy outcomes getting worse overall for both babies and mothers worldwide, according to an international data review published on Wednesday.

Pooling data from 40 studies across 17 countries, the review found that lockdowns, disruption to maternity services, and fear of attending healthcare facilities all added to pregnancy risks, leading to generally worse results for women and infants.

“The COVID-19 pandemic has had a profound impact on healthcare systems,” said professor Asma Khalil, who co-led the research at St George’s University of London. “The disruption caused … has led to the avoidable deaths of both mothers and babies, especially in low- and middle-income countries.”

Published in the Lancet Global Health journal, the review found an overall increase in the risks of stillbirth and maternal death during the pandemic, and found the impact on poorer countries was disproportionately greater.

It also found significant harm to maternal mental health. Of the 10 studies included in the analysis that reported on maternal mental health, six found an increase in postnatal depression, maternal anxiety, or both.

The study did not analyze the direct impact of COVID-19 infection itself during pregnancy, but was designed to look at the collateral impact of the coronavirus pandemic on antenatal, birth and postnatal outcomes.

Commenting on the findings, Jogender Kumar of the Postgraduate Institute of Medical Education and Research in India said they highlighted worrying disparities in healthcare.

“In resource-poor countries, even under normal circumstances, it is a challenge to provide adequate coverage for antenatal checkups, obstetric emergencies, universal institutional deliveries and respectful maternity care,” he wrote in a commentary. “The COVID-19 pandemic has widened this gap.”

(Reporting by Kate Kelland, Editing by William Maclean)

Macron orders COVID-19 lockdown across all of France, closes schools

By Sudip Kar-Gupta and Geert De Clercq

PARIS (Reuters) -President Emmanuel Macron on Wednesday ordered France into its third national lockdown and said schools would close for three weeks as he sought to push back a third wave of COVID-19 infections that threatens to overwhelm hospitals.

With the death toll nearing 100,000, intensive care units in the hardest-hit regions at breaking point and a slower-than-planned vaccine rollout, Macron was forced to abandon his goal of keeping the country open to protect the economy.

“We will lose control if we do not move now,” the president said in a televised address to the nation.

His announcement means that movement restrictions already in place for more than a week in Paris, and some northern and southern regions, will now apply to the whole country for at least a month, from Saturday.

Departing from his pledge to safeguard education from the pandemic, Macron said schools will close for three weeks after this weekend.

Macron, 43, has sought to avoid a third large-scale lockdown since the start of the year, betting that if he could steer France out of the pandemic without locking the country down again he would give the economy a chance to recover from last year’s slump.

But the former investment banker’s options narrowed as more contagious strains of the coronavirus swept across France and much of Europe.

For school-children after this weekend, learning will be done remotely for a week, after which all schools go on a two-week holiday. Thereafter, nursery and primary pupils will return to school while middle and high school pupils continue distance learning for an extra week.

“It is the best solution to slow down the virus,” Macron said, adding that France had succeeded in keeping its schools open for longer during the pandemic than many neighbors.

Daily new infections in France have doubled since February to nearly 40,000. The number of COVID-19 patients in intensive care has breached 5,000, exceeding the peak hit during a six-week-long lockdown late last year.

Bed capacity in critical care units will be increased to 10,000, Macron said.

The new restrictions risk slowing the pace of recovery in the euro zone’s second-largest economy from last year’s slump.

Macron said the vaccine rollout needed to be accelerated. It is only now finding its stride three months in, with just 12% of the population inoculated.

(Additional reporting by Michel Rose and Jean-Stephane Brosse; Writing by Richard Lough; Editing by Christian Lowe)

COVID-19 third leading cause of U.S. deaths in 2020 after heart disease, cancer: U.S. report

By Vishwadha Chander

(Reuters) – COVID-19 was the primary or contributing cause of 377,883 deaths in the United States last year, with a particularly high toll among the elderly, according to a government report released on Wednesday.

The COVID-19 mortality rate made it the third leading cause of death in the United States in 2020 after heart disease and cancer, the U.S. Centers for Disease Control and Prevention (CDC) analysis found.

The CDC said that the overall U.S. mortality rate increased for the first time since 2017, by nearly 16%, to 3,358,814 deaths. The jump was driven by COVID-19, which accounted for an increase of 11.3%.

The overall death rate was lowest among children aged 5 to 14 years, and highest among people over age 85, the report found. A total of 134 children aged 14 and under died from COVID-19 in 2020, while 120,648 people aged 85 and older died from the disease. People 75-84 years old accounted for 104,212 deaths.

The COVID-19 death rate was highest among Hispanics, followed by Black non-Hispanics, the CDC’s analysis found. A total of 68,469 Hispanics died from COVID-19 and 59,871 non-Hispanic Black people died. It said 228,328 White non-Hispanics died.

The CDC report is based on death certificate data between January and December 2020.

Provisional estimates from the CDC, published last month, showed that life expectancy in the U.S. fell by a year in the first half of 2020 – the biggest decline since World War 2 – and stood at the lowest levels since 2006.

The CDC’s current analysis is based on provisional death estimates, but they provide an early indication of shifts in mortality trends, the agency said.

The CDC pointed out that limited availability of testing for the coronavirus at the beginning of the pandemic might have resulted in an underestimation of COVID-19–associated deaths.

(Reporting by Reporting by Vishwadha Chander and Caroline Humer; Editing by Bill Berkrot)

Hungarian journalists say state conceals impact of world’s deadliest COVID-19 outbreak

By Marton Dunai

BUDAPEST (Reuters) – Hungarian journalists accused the government on Wednesday of putting lives at risk by barring the media from covering the full extent of what is now the world’s deadliest COVID-19 outbreak.

In an open letter published by most of the country’s independent news outlets, reporters said they had been blocked from hospitals and barred from speaking to medics, making it impossible to alert the public to the crisis.

Hungary, with 10 million people, reported 302 deaths on Tuesday, its highest since the start of the pandemic, and now has the highest weekly toll per capita in the world. Doctors speaking on condition of anonymity have told Reuters that hospitals are being overrun.

Hungary’s nationalist government denies there is a capacity crisis, and state-run media have depicted the situation in hospitals as under control. The government says it aims to reopen the economy by bringing in vaccines, including shots from Russia and China yet to be approved by the EU.

“Doctors and nurses are not free to talk to the public, while journalists are not allowed in hospitals, so we cannot assess what happens there,” read the letter published in 28 independent newspapers, websites and other outlets.

The Council of Europe said on Tuesday that Hungarian media workers faced increasing problems covering the pandemic. The government dismissed those remarks as “based on presumptions and allegations”.

Government spokesman Zoltan Kovacs said there would be no laxer rules, and accused “left-wing portals” of spreading “fake news” to embarrass the country’s health care system.

“We must use hospitals to heal, not shoot footage,” Kovacs wrote on Facebook on Wednesday. “Hungarian doctors and nurses perform exceptionally. Let them work!”

Activists and international bodies have accused Prime Minister Viktor Orban’s government of cracking down on free media since it took power in 2010. The government denies interfering with what it calls a free press.

Doctors have also raised the alarm that news coverage which fails to show the extent of the crisis could make it worse.

“I warn all political forces and their media that one-sided information, censorship delays recognizing the faults of health care, which could cost lives,” Janos Szijjarto, chairman of the doctors’ association from Gyor, Western Hungary, wrote on Facebook earlier this month.

(Reporting by Marton Dunai; Editing by Andrew Heavens and Peter Graff)