Moderna to supply four million more doses of COVID-19 vaccine to Israel

(Reuters) – Moderna Inc said on Friday it has extended its contract with the Israeli health ministry to supply an additional 4 million doses of its COVID-19 vaccine candidate.

Israel has now secured access to 6 million doses of Moderna’s mRNA-1273, currently under review in the country.

Financial terms and delivery timelines related to the deal were not disclosed.

In June, Israel signed an agreement with Moderna for its vaccine to protect its people from the new coronavirus. The country, with a population of 9 million, has reported 339,942 cases and 2,890 deaths, according to a Reuters tally.

It has also reached an understanding with AstraZeneca Plc to receive about 10 million doses of its experimental COVID-19 vaccine.

Moderna said it continues to scale up its global manufacturing to boost delivery by about 500 million doses per year, and possibly up to 1 billion doses a year, beginning 2021.

The company has submitted applications seeking emergency use authorization in the United States and EU after full results from a late-stage study showed the vaccine was 94.1% effective with no serious safety concerns.

(Reporting by Manojna Maddipatla in Bengaluru; Editing by Shinjini Ganguli)

Coronavirus claims 1.5 million lives globally with 10,000 dying each day

By Shaina Ahluwalia and Sangameswaran S

(Reuters) – Over 1.5 million people have lost their lives due to COVID-19 with one death reported every nine seconds on a weekly average, as vaccinations are set to begin in December in a handful of developed nations.

Half a million deaths occurred in just the last two months, indicating that the severity of the pandemic is far from over. Nearly 65 million people globally have been infected by the disease and the worst affected country, United States, is currently battling a third wave of coronavirus infections.

In the last week alone, more than 10,000 people in the world died on average every single day, which has been steadily rising each passing week. Many countries across the world are now fighting second and third waves even greater than the first, forcing new restrictions on everyday life.

The novel coronavirus caused more deaths in the past year than tuberculosis in 2019 and nearly four times the number of deaths due to malaria, according to the World Health Organization.

Robert Redfield, the head of the U.S. Centers for Disease Control and Prevention, warned on Wednesday that the pandemic will pose the country’s grimmest health crisis yet over the next few months, before vaccines become widely available.

“I actually believe they’re going to be the most difficult time in the public health history of this nation,” Redfield told a livestream presentation hosted by the U.S. Chamber of Commerce Foundation.

The United States continues to lead in terms of fatalities, with over 273,000 deaths alone. North America and Latin American regions combined have more than 50% of all coronavirus deaths that have been reported.

The Latin American region, the worst-affected globally in terms of fatalities, recently surpassed over 450,000 deaths.

VACCINE HOPES

On Wednesday, Britain became the first country to approve the vaccine candidate developed by Germany’s BioNTech and Pfizer Inc, jumping ahead of the rest of the world in the race to begin a crucial mass inoculation program.

However, supplies are expected to be very limited in the early stages which means that every country beginning the drive will have to prioritize based on risk factors.

U.S. health regulators are expected to approve distribution and administration of the vaccine in mid-December.

Africa aims to have 60% of its population vaccinated against COVID-19 within the next two to three years, the African Union’s disease control group said on Thursday. The continent of 1.3 billion people has recorded more than 2.2 million confirmed coronavirus infections, according to a Reuters tally.

(Reporting by Shaina Ahluwalia and Sangameswaran S in Bengaluru; Editing by Lisa Shumaker)

How COVID upended life as we knew it in a matter of weeks

By Alexandra Hudson

(Reuters) – On Jan. 1, 2020, as the world welcomed a new decade, Chinese authorities in Wuhan shut down a seafood market in the central city of 11 million, suspecting that an outbreak of a new “viral pneumonia” affecting 27 people might be linked to the site.

Early lab tests in China pointed to a new coronavirus. By Jan. 20 it had spread to three countries.

For most people, it was a minor health scare unfolding half a world away.

Nearly a year later it has changed lives fundamentally. Almost everyone has been affected, be it through illness, losing loved ones or jobs, being confined at home and having to get used to a whole new way of working, relaxing and interacting.

Almost 1.5 million people have died globally from the COVID-19 disease related to the coronavirus, and some 63 million people have been infected.

After the initial “wave” of the pandemic was brought under some semblance of control in many countries, nations are now fighting second and third waves even greater than the first, forcing new restrictions on everyday life.

Among the most haunting images to emerge from the pandemic in 2020 are those of medics on the frontlines of the battle against the virus.

In Milan’s San Raffaele hospital, seven intensive care unit staff attended to an 18-year-old patient suffering from COVID-19, pushing the bed into the ward and holding medical equipment and monitors.

Doctors and nurses like them swathed in protective gear – gowns, gloves, masks, and visors, some with their names or initials written on their uniforms – have become a familiar sight.

So, too, have images of medics collapsing from exhaustion or grief at losing one of their own to the disease.

By March and April many countries began to impose lockdowns and social distancing to slow the spread of the highly contagious virus.

Structures to separate and protect people sprang up – from transparent screens at supermarket checkouts to the plastic sheet which allowed 83-year-old Lily Hendrickx, a resident at a Belgian nursing home, to hug Marie-Christine Desoer, the home’s director.

The effects on the natural world of the shutdown were sometimes astonishing. Birdsong could be heard like never before in towns and wild animals ventured into newly empty cities.

At the usually crowded Golden Gate Bridge View Vista Point across from San Francisco, a coyote stood by the roadside.

Even the streets of Manhattan were eerily empty.

Ballet dancer Ashlee Montague donned a gas mask and danced in the middle of Times Square, New York.

In Brazil’s capital, Brasilia, Catholic priest Jonathan Costa prayed alone at the Santuario Dom Bosco church, among photographs of the faithful, attached to the pews.

Wearing masks to combat the spread of the virus became commonplace the world over.

At Tokyo’s Shinagawa train station, crowds of commuters wore face masks, as did prisoners crowded into a cell in El Salvador’s Quezaltepeque jail.

In private homes, families learned to live together 24 hours a day and how to entertain and teach their children.

The pandemic hit some of the world’s poorest people the hardest – exposing the inequalities in access to medical treatment and in government funds to compensate people who lost their livelihoods.

In South Africa in May, at the Itireleng informal settlement near Laudium suburb in Pretoria, people waited in a queue that stretched as far as the eye could see to receive food aid.

As 2020 heads to its close, vaccines are on the horizon. There is hope that some aspects of life as we knew it will return.

(Writing by Alexandra Hudson; Editing by Mike Collett-White)

U.S. pandemic death toll mounts as danger season approaches

By Susan Heavey

WASHINGTON (Reuters) – U.S. deaths from the coronavirus pandemic have surged past 2,000 for two days in a row as the most dangerous season of the year approached, taxing an overwhelmed healthcare system with U.S. political leadership in disarray.

The toll from COVID-19 reached its second-highest level ever on Wednesday with 2,811 lives lost, according to a Reuters tally of official data, one short of the record from April 15.

Nearly 200,000 new U.S. cases were reported on Wednesday, with record hospitalizations approaching 100,000 patients.

The sobering data came as the head of the U.S. Centers for Disease Control and Prevention on Wednesday warned that December, January and February were likely to be “the most difficult time in the public health history of this nation.”

CDC Director Dr. Robert Redfield told an event hosted by the U.S. Chamber of Commerce that the United States could start losing around 3,000 people – roughly the number that died in the attacks of Sept. 11, 2001 – each day over the next two months.

“The mortality concerns are real and I do think unfortunately before we see February, we could be close to 450,000 Americans that have died from this virus,” Redfield said. The U.S. death toll since the start of the pandemic stands at around 273,000.

Hospitals are filling up with COVID-19 patients, reducing care for people needing treatment for other ailments. Redfield said 90% of U.S. hospitals were in areas designated as coronavirus “hot zones.”

Rural and suburban hospitals were particularly affected, threatening their economic viability, Amesh Adalja, a senior scholar at the Johns Hopkins Center for Health Security, told MSNBC on Thursday.

“There’s no end in sight because there’s so much community spread,” Adalja said, warning that the pandemic could force hospital closures.

Still, rapid vaccine development, aided by the Trump administration’s “Operation Warp Speed” program, offered a ray of hope.

Britain on Wednesday gave emergency approval to Pfizer Inc’s COVID-19 vaccine, a sign that U.S. regulators may soon follow suit and allow inoculations within weeks.

(Reporting by Susan Heavey and Daniel Trotta; Writing by Daniel Trotta; Editing by Bernadette Baum)

U.S. plans for first COVID vaccines as pandemic deaths surge again

By Julie Steenhuysen and Doina Chiacu

WASHINGTON (Reuters) – Top U.S. health officials announced plans on Tuesday to begin vaccinating Americans against the coronavirus as early as mid-December, as nationwide deaths hit the highest number for a single day in six months.

Some 20 million people could be inoculated against COVID-19 by the end of 2020 and most Americans will have access to highly effective vaccines by mid-2021, the chief adviser of President Donald Trump’s Operation Warp Speed program said.

“Within 24 hours, maybe at most 36 to 48 hours, from the approval, the vaccine can be in people’s arms,” Moncef Slaoui, a former GlaxoSmithKline executive who is overseeing the vaccine portion of the U.S. program, said at an event conducted by The Washington Post newspaper.

His comments came on the same day that another 2,295 fatalities nationwide were linked to COVID-19, even before California, the most populous U.S. state, reported full results. Officials in several states said numbers were higher in part due to a backlog from the Thanksgiving holiday.

A statement from the public health director for Los Angeles County highlighted the ravages of the surging pandemic. Barbara Ferrer, the public health director, said that while Tuesday was the county’s “worst day thus far” of the pandemic, “…it will likely not remain the worst day of the pandemic in Los Angeles County. That will be tomorrow, and the next day and the next as cases, hospitalizations and deaths increase.”

Health officials pleaded with Americans to stick with coronavirus restrictions even with a vaccine in sight.

The U.S. Centers for Disease Control and Prevention is moving to shorten the length of self-quarantine recommended after potential exposure to the coronavirus to 10 days, or seven days with a negative test, a federal spokesperson said on Tuesday. The CDC currently recommends a 14-day quarantine in order to curb the transmission of the virus.

TIMELINE ON A VACCINE

Some 60 million to 70 million doses of COVID-19 vaccine could be available per month beginning in January, after the expected regulatory approval of products from Pfizer Inc and Moderna Inc, Slaoui said.

A Food and Drug Administration panel of outside advisers will meet on Dec. 10 to discuss whether to recommend emergency use authorization of the Pfizer vaccine, developed with German partner BioNTech SE. Moderna’s vaccine candidate is expected to be reviewed a week later.

The timeline described by Slaoui and Health and Human Services Secretary Alex Azar appeared to assume that the FDA’s authorization of the first vaccine would come within days of the Dec. 10 meeting.

But the head of the FDA’s Center for Biologics Evaluation and Research, Dr. Peter Marks, told patient advocacy groups last week that it might take “a few days to a few weeks.”

FDA Commissioner Stephen Hahn, likewise, has said the process could take longer.

The U.S. Transportation Department said on Tuesday it has made preparations to enable the “immediate mass shipment” of COVID-19 vaccines and completed all necessary regulatory measures.

An estimated 21 million healthcare workers and 3 million residents of long-term care facilities should be first in line to receive a vaccine, according to a recommendation voted on by a CDC panel of advisers on Tuesday.

Nursing homes are experiencing the worst outbreak of weekly coronavirus cases since the spring, according to the American Health Care Association and National Center for Assisted Living.

HOLIDAY TRAVEL SPIKE

State and local officials have returned to imposing restrictions on businesses and activities in response to the latest surge of a pandemic that killed 37,000 people in November.

A record nearly 96,000 COVID-19 patients were reported in U.S. hospitals on Tuesday, according to a Reuters tally.

Hospitalizations and deaths are expected to spike even higher during the holiday travel season, a trend that officials warn could overwhelm already strained healthcare systems.

The monthly death toll from COVID-19 is projected to nearly double in December to a pandemic-high of more than 70,000 and surpass 76,000 in January before ebbing in February, according to a widely cited model from the University of Washington’s Institute for Health Metrics and Evaluation.

Pandemic-related restrictions have ravaged the U.S. economy. A bipartisan group of U.S. lawmakers on Tuesday unveiled a $908 billion COVID-19 relief bill aimed at breaking a deadlock over emergency assistance for small businesses, industries and the unemployed.

(Reporting by Doina Chiacu and Julie Steenhuysen; Additional reporting by Lisa Shumaker, Maria Caspani, Peter Szekely, Jonathan Allen, David Shepardson, Steve Gorman and Dan Whitcomb; Writing by Daniel Trotta and Dan Whitcomb; Editing by Bill Berkrot, Bill Tarrant and Leslie Adler)

U.S. reports over 10,000 coronavirus deaths last week

(Reuters) – The United States recorded 10,000 coronavirus deaths and over 1.1 million new cases last week, although state and health officials have said the Thanksgiving holiday likely caused numbers to be under-reported.

New cases fell 3.8% in the week ended Nov. 29, while deaths fell 3.9%, according to a Reuters analysis of state and county reports. Many testing centers were closed on Thursday for Thanksgiving and some private labs had reduced staffing or were closed on Friday, according to state and health officials.

They said that figures for cases and deaths this week may be abnormally high due to a backlog of data from last week.

Hospitals, which were not closed due to holidays, may provide the most accurate data for last week. Hospitalized COVID-19 patients reached a record high of nearly 93,000 on Sunday, up 11% from last week and double the number reported a month ago, according to the Reuters analysis.

Cases rose by 91% in Washington state last week, the biggest percentage increase in the country, followed by California at 31% and New York with a 25% increase.

Illinois reported 831 COVID-19 deaths last week, the highest for any state, followed by Texas with 806 deaths.

Across the United States, 9.8% of tests came back positive for the virus for a third week in a row, according to data from The COVID Tracking Project, a volunteer-run effort to track the outbreak. Out of 50 states, 29 had positive test rates above 10%. The highest rates were Iowa at 50%, Idaho at 44% and South Dakota at 41%.

The World Health Organization considers positive test rates above 5% concerning because it suggests there are more cases in the community that have not yet been uncovered.

(Graphic by Chris Canipe, writing by Lisa Shumaker, editing by Tiffany Wu)

U.S. CDC reports 259,005 deaths from coronavirus

(Reuters) – The U.S. Centers for Disease Control and Prevention (CDC) on Wednesday reported 12,498,734 cases of the new coronavirus, an increase of 165,282 from its previous count, and said that the number of deaths had risen by 1,989 to 259,005.

The CDC reported its tally of cases of the respiratory illness known as COVID-19, caused by a new coronavirus, as of 4 pm ET on Nov. 24 versus its previous report a day earlier.

The CDC figures do not necessarily reflect cases reported by individual states.

(Reporting by Dania Nadeem in Bengaluru)

U.S. hits highest death toll since May with hospitals already full

By Daniel Trotta

(Reuters) -Daily U.S. deaths from COVID-19 surpassed 2,000 for the first time since May and with hospitals across the country already full, portending a surge in mortalities to come as the coronavirus pandemic casts a shadow over the holiday season.

The death toll reached 2,157 on Tuesday – one person every 40 seconds – with another 170,000 people infected, numbers that experts say could grow with millions of Americans disregarding official warnings and traveling for Thursday’s Thanksgiving holiday.

The deadliest day in more than six months was still short of the record of 2,806 deaths on April 14, in the early stages of the pandemic, according to a Reuters tally of official data. That one-day figure is sometimes reported higher due to a backlog of deaths that were not compiled until April 14.

With U.S. hospitalizations for COVID-19 reaching a record high of 87,000 on Tuesday, the nation’s leading infectious diseases official urged people to keep Thanksgiving gatherings as small as possible.

Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, stressed the need to “hang in there a bit longer” on wearing masks, maintaining distance and avoiding crowds, especially indoors.

“If we do those things, we’re going to get through it. So that’s my final plea before the holiday,” Fauci told the ABC News program “Good Morning America” on Wednesday.

Families with university students have been forced to evaluate the risk of reuniting for Thanksgiving.

Francesca Wimer, a student at Northwestern University in Illinois, flew home to Washington wearing an N95 mask and a face shield and checked into a hotel for 14 days, quarantining to protect her parents and grandparents.

“She was returning to a vulnerable set of people. We didn’t trust that a test was enough,” said her mother, Cynthia Wimer.

Others are just staying put.

Luke Burke, studying at Syracuse University in upstate New York, was planning to spend Thanksgiving with his family in New Jersey until his roommate tested positive last week.

“I’m sorry I can’t be there with my parents, but it’s the right thing to do,” Burke said.

Meanwhile school districts across the United States face pressure from all sides as they grapple with how to educate children during the pandemic, a Reuters survey of 217 districts showed.

Many parents are balking at online instruction, while others worry about sending kids back into classrooms prematurely. Teachers say they are not comfortable teaching in person.

“Every school district across the nation is in the position in which no matter what decision they make and how well thought out it is, it will leave some in the community thinking it’s the wrong decision,” said Larry Rother, senior executive director of pre-kindergarten through 12th-grade educational services in Chandler, Arizona.

Help may be coming with vaccines showing promise.

Officials from the U.S. government’s Operation Warp Speed program told reporters on Tuesday they plan to release 6.4 million COVID-19 vaccine doses nationwide in an initial distribution after the first one is cleared by regulators for emergency use, which could happen as soon as Dec. 10.

If all goes well, 40 million doses will be distributed by the end of the year, they said.

A Food and Drug Administration ruling on emergency use for Pfizer Inc’s vaccine is expected on Dec. 10.

(Reporting by Daniel Trotta, Lisa Shumaker, Gabriella Borter, Lisa Lambert, Kristina Cooke, Benjamin Lesser, M.B. Pell and Simon Lewis; Editing by Chizu Nomiyama, Andrea Ricci and Jonathan Oatis)

U.S. posts sharpest weekly rise in COVID-19 deaths since August

(Reuters) – The United States recorded its biggest weekly rise in COVID-19 deaths since August, increasing 32% from the previous week to average about 1,500 people per day, according to a Reuters analysis of state and county reports.

New cases rose 13% in the week ended Nov. 22, or an average of more than 168,000 per day

Ahead of the Thanksgiving holiday this Thursday, at least 23 states have announced new restrictions to try to slow the spread of the virus but so far only New Mexico has issued a stay-at-home order.

Cases rose by 90% in New Mexico last week, the biggest percentage increase in the country, followed by Virginia at 62% and Arizona with a 50% increase.

In North Dakota, the hardest hit state on a per capita basis, nearly 73,400 tests have come back positive for the new coronavirus since the beginning of the outbreak. That is equivalent to 9.6% of the state’s population. North Dakota mandated masks starting Nov. 14 but another 14 states still do not require them.

Across the United States, 9.8% of tests came back positive for the virus for a second week in a row, according to data from The COVID Tracking Project, a volunteer-run effort to track the outbreak.

The World Health Organization considers positive test rates above 5% concerning because it suggests there are more cases in the community that have not yet been uncovered.

Out of 50 states, 26 had positive test rates above 10% last week, led by Iowa at 56%, South Dakota at 45% and Idaho at 40%.

(Graphic by Chris Canipe, writing by Lisa Shumaker, editing by Tiffany Wu)

U.S. CDC reports 255,958 deaths from coronavirus

(Reuters) – The U.S. Centers for Disease Control and Prevention (CDC) on Monday reported 12,175,921 cases of the new coronavirus, an increase of 147,840 from its previous count, and said that the number of deaths had risen by 882 to 255,958.

The CDC reported its tally of cases of the respiratory illness known as COVID-19, caused by a new coronavirus, as of 4 pm ET on Nov. 22 versus its previous report a day earlier.

The CDC figures do not necessarily reflect cases reported by individual states.

(Reporting by Dania Nadeem in Bengaluru; Editing by Devika Syamnath)