South Korea city deserted after coronavirus church ‘super-spreader’

y Hyonhee Shin and Ryan Woo

SEOUL/BEIJING (Reuters) – The streets of South Korea’s fourth-largest city were abandoned on Thursday, with residents holed up indoors after dozens of people caught the coronavirus in what the authorities described as a “super-spreading event” at a church.

The deserted shopping malls and cinemas of Daegu, a city of 2.5 million people, became one of the most striking images outside China of an outbreak that international authorities are trying to prevent from spreading into a global pandemic.

New research suggesting the virus was more contagious than previously thought added to the alarm. And in China, where the virus has killed more than 2,100 people, officials changed their methodology for reporting infections, creating new doubt about data they have been citing as evidence of success in fighting its spread.

Deagu Mayor Kwon Young-jin told residents to stay indoors after 90 people who worshipped at the Church of Jesus the Temple of the Tabernacle of the Testimony showed symptoms of infection and dozens of new cases were confirmed.

The church had been attended by a 61-year-old woman who tested positive, known as “Patient 31”. Korea’s Centers for Disease Control and Prevention described the outbreak there as a “super-spreading event”.

“We are in an unprecedented crisis,” Kwon told reporters, adding that all members of the church would be tested. “We’ve asked them to stay at home isolated from their families.”

Describing the abandoned streets, resident Kim Geun-woo, 28, told Reuters by telephone: “It’s like someone dropped a bomb in the middle of the city. It looks like a zombie apocalypse.”

South Korea now has 104 confirmed cases of the flu-like virus, and reported its first death.

In China, officials have been pointing to evidence that new cases were declining as proof they are succeeding in keeping the virus largely contained to Hubei Province and its capital Wuhan, where the virus initially emerged.

But revisions to their methodology have raised doubts about the data. Under the latest methodology, which excludes chest X-rays, China reported fewer than 400 new cases over the past day, less than a quarter of the number it had been finding in recent days under the previous method.

Only last week, another change in Chinese methodology created an overnight spike of nearly 15,000 new cases, reversing a trend of falling numbers that Chinese officials had previously touted as evidence their disease-fighting strategy was working.

Scientists in China who studied nose and throat swabs from 18 patients infected with the virus said it behaves much more like influenza than other closely related viruses, suggesting it may spread even more easily than previously believed.

In at least in one case, the virus was present even though the patient had no symptoms, suggesting symptom-free patients could spread the disease, they wrote in preliminary findings published in the New England Journal of Medicine.

“If confirmed, this is very important,” said Dr Gregory Poland, a vaccine researcher with the Mayo Clinic in Rochester, Minnesota, who was not involved with the study.

China has imposed severe controls in Wuhan, a city of 11 million people, to halt the spread of the virus, and has taken urgent steps to keep the overall economy from crashing.

On Thursday, its central bank cut a borrowing rate, while the authorities extended an order for businesses in Wuhan to shut down until March 11. Schools in the city, which had been due to re-open on Friday, will also stay shut.

TWO CRUISE SHIP PASSENGERS DIE

Japan reported the deaths of two elderly passengers from the quarantined Diamond Princess cruise ship anchored off Yokohama. They appear to be the first people to have died from the disease from aboard the ship, the biggest cluster of infection outside mainland China with more than 620 cases.

Japan has begun allowing passengers who test negative to disembark from the ship. Hundreds departed on Wednesday and hundreds more were set to leave on Thursday.

The ship was carrying about 3,700 people when quarantined on Feb. 3, about half of them from Japan. Japanese passengers were permitted to go home once cleared to leave; other countries are flying passengers home and keeping them isolated on arrival.

Japan, which is due to host the summer Olympics in July, had faced criticism over its strategy of quarantining people on board the ship. Its National Institute of Infections Diseases published data which it said supported its strategy, showing that the onset of symptoms from confirmed cases had peaked on Feb. 7 and tailed off to zero by Feb. 15.

The NIID report was “very reassuring,” said Kentaro Iwata, an infectious disease specialist from Kobe University Hospital who had been one of the harshest critics of the quarantine.

(Reporting by Hyonhee Shin in Seoul and Ryan Woo in Beijing; Additional reporting by Linda Sieg, Chang-Ran Kim, Akiko Okamoto, Ju-min Park and Daewong Kim in Tokyo, Sangmi Cha in Seoul, Babak Dehghanpisheh and Parisa Hafezi in Dubai, Keith Zhai and Patpicha Tanakasempipat in Vientiane; Writing by Peter Graff, Editing by Angus MacSwan)

Countries rush to build diagnostic capacity as coronavirus spreads

By Julie Steenhuysen and Stephanie Nebehay

CHICAGO/GENEVA (Reuters) – A week ago, only two laboratories in Africa could diagnose the novel coronavirus that originated in China and is rapidly spreading around the world. As of Sunday, the World Health Organization (WHO) expected every nation in Africa to be able to diagnose the disease.

The rush reflects a global push for diagnostic capabilities, particularly in developing countries, in hopes of averting a global pandemic. But it is being slowed by a desperate need for virus samples necessary to validate the tests.

“Without vital diagnostic capacity, countries are in the dark as to how far and wide the virus has spread and who has coronavirus or another disease with similar symptoms,” WHO chief Tedros Adhanom Ghebreyesus told a news conference in Geneva on Monday.

As of early Tuesday, there had been 42,708 confirmed cases reported in China and 1017 deaths, as well as 319 cases in 24 other countries, including one death.

Most of the testing is being done by public health laboratories. But several companies including Thermo Fisher Scientific Inc, GenScript Biotech Corp and Co-Diagnostics Inc have developed tests and are taking steps to get them validated for clinical use.

Roche is distributing coronavirus tests developed by Tib Molbiol of Berlin for research use on some of its instruments while developing a test of its own. Abbott Laboratories also is working on a test.

WHO has activated a network of 15 referral laboratories that can support national efforts in confirming new cases, and has identified 168 labs globally with the technology to diagnose the virus.

FILE PHOTO: Workers wearing protective suits drive an ambulance near the cruise ship Diamond Princess, as they prepare to transfer passengers tested positive for the novel coronavirus, at Daikoku Pier Cruise Terminal in Yokohama, south of Tokyo, Japan February 10, 2020. REUTERS/Kim Kyung-Hoon/File Photo

Technicians must be trained to run the tests locally to avoid delays associated with having to send them to centralized labs.

On Tuesday, WHO is convening a two-day meeting of hundreds of researchers and manufacturers to address the outbreak.

WORKLOAD ON LABS IS ‘EXTREME’

Researchers are also working to develop antibody tests that can tell whether someone has been exposed to the virus. They could help answer how broadly this virus has spread, and whether there are milder cases not being detected, Dr. Mike Ryan, head of the WHO emergency program, told reporters.

China appears to have adequate stock of the materials needed to perform diagnostic tests, but there is a limited number of trained technicians who can run them. “The workload on those labs is extreme,” Ryan said.

Outside of China, manufacturers are quickly developing tests based on the genetic code of the virus. Those tests still need to be validated with actual virus samples, for which access has been challenging.

Live isolation of the virus allows a huge advance in diagnostics and potential advances in therapeutics and vaccine development, Ryan said.

GenScript, which has offices in New Jersey and Nanjing, China, has developed a test available to researchers. It cannot be used as a diagnostic until it has been tested in hundreds of virus samples.

“In China, we couldn’t get to the samples directly because we don’t have a lab that can handle the virus,” said Hong Li, a GenScript scientist.

The company has sent its test kits to Chinese health officials to assess their validity. “Because other companies in China are also doing that, we don’t know when it will be our turn,” said Eric Wang, GenScript’s head of marketing.

Utah-based Co-Diagnostics on Monday said it has started shipping its test, which is available for research purposes, to clients. Chief Scientific Officer Brent Satterfield said last week that the company has been struggling to find clinical virus samples to validate the test for use as a diagnostic.

Thermo Fisher developed its tests based on the genetic code of the virus, and ran computer models to validate it.

The company has been providing its test to countries and health ministries with access to virus samples, said Thermo Fisher executive Joshua Trotta. “They will evaluate our kits and make a determination of what is the best test to deploy.”

Meanwhile, Thermo Fisher is scaling up production as countries prepare for more cases. Demand is “growing every day,” Trotta said.

(Reporting by Julie Steenhuysen in Chicago and Stephanie Nebehay in Geneva; Editing by Bill Berkrot)

China orders ‘unprecedented’ lockdown of two cities at virus epicenter

China orders ‘unprecedented’ lockdown of two cities at virus epicenter
By Yawen Chen and Se Young Lee

BEIJING (Reuters) – China on Thursday locked down two cities at the epicenter of a coronavirus outbreak that has killed 17 people and infected nearly 600, as health authorities around the world took action to prevent a global pandemic.

Health officials fear the transmission rate will accelerate as hundreds of millions of Chinese travel at home and abroad during week-long holidays for the Lunar New Year, which begins on Saturday.

The previously unknown virus strain is believed to have emerged late last year from illegally traded wildlife at an animal market in the central Chinese city of Wuhan.

Most transport in Wuhan, a city of 11 million people, was suspended on Thursday morning and people were told not to leave. Hours later, neighboring Huanggang, a city of about 7 million people, announced a similar lockdown.

“The lockdown of 11 million people is unprecedented in public health history, so it is certainly not a recommendation the WHO has made,” Gauden Galea, the World Health Organization’s representative in Beijing, told Reuters.

Other cities were also taking steps to restrict movement and contact. Nearby Ezhou shut its train stations. The capital Beijing canceled major public events, including two well-known Lunar New Year temple fairs, the state-run Beijing News said.

Airports worldwide were screening passengers arriving from China.

There is no vaccine for the virus, which can spread through respiratory transmission. Symptoms include fever, difficulty in breathing and cough, similar to many other respiratory illnesses.

Preliminary research suggested it was passed on to humans from snakes, but government medical adviser Zhong Nanshan has also identified badgers and rats as possible sources.

WHO MEETING

The WHO has said it will decide on Thursday whether to declare the outbreak a global health emergency, which would step up the international response.

If it does so, it will be the sixth international public health emergency to be declared in the last decade. A WHO news conference is expected some time after 1800 GMT.

Chinese authorities gave no new details on the numbers of virus infections but it has been reported in Beijing, Shanghai and Hong Kong. Of eight known cases worldwide, Thailand has confirmed four, while Japan, South Korea, Taiwan and the United States have reported one each.

Authorities had confirmed 571 cases and 17 deaths by the end of Wednesday, China’s National Health Commission said. Earlier, it said another 393 suspected cases had been reported.

In a report on Wednesday, Imperial College London said it estimated a total of 4,000 cases of the coronavirus in Wuhan alone as of Jan. 18, an infection rate based on the number of cases reported in China and elsewhere.

Wuhan shut down all urban transport networks and suspended outgoing flights from 10 a.m. (0200 GMT). Domestic media said some airlines were operating after the deadline, however.

Wuhan’s Hankou rail station was nearly deserted, with gates blocked, state broadcasts showed. The government urged citizens not to leave the city.

State media reported highway toll booths around Wuhan were closing down, which would effectively cut off road exits. Guards were patrolling highways, one resident told Reuters.

As the city slipped into isolation, residents thronged into hospitals for checks and scrambled for supplies, clearing out supermarket shelves and queuing for petrol.

Authorities in Huanggang ordered indoor entertainment venues including cinemas and internet cafes to close.

FACE MASKS

In contrast with its secrecy over the 2002-03 Severe Acute Respiratory Syndrome (SARS) that killed nearly 800 people, China’s Communist Party government has provided regular updates to avoid panic ahead of the holidays.

During a visit to Wuhan, Vice Premier Sun Chunlan said authorities needed to be open about the virus and efforts to contain it, the official Xinhua news agency said.

Some experts believe the new virus is not as dangerous as previous coronaviruses such as SARS and Middle East Respiratory Syndrome (MERS), which has killed more than 700 people since 2012.

“The early evidence at this stage would suggest it’s not as severe,” Australia’s Chief Medical Officer Brendan Murphy told reporters.

Despite China’s response, world shares fell on Thursday, led by the biggest tumble in Chinese stocks in more than eight months, as concern mounted about the outbreak. China’s yuan fell to a two-week low. [MKTS/GLOB]

The economic impact of such outbreaks are hard to quantify but a 2006 estimate by the International Air Transport Association (IATA) calculated that SARS shaved just over 1 percentage point off the GDP of China in 2003.

InterContinental Hotels and Hyatt are allowing guests to change or cancel stays at most Chinese hotels.

A general view shows the monitors of thermal scanners that detect temperatures of passengers at the security check inside the airport in Guatemala City, Guatemala January 22, 2020. REUTERS/Luis Echeverria

Many Chinese were cancelling trips, buying face masks and avoiding shopping centers.

The release of seven movies over the Lunar New Year has been postponed. The holiday is the high season for distributors and cinemas attract huge crowds.

Airports globally, including in Britain, stepped up screening of passengers from China and the European Centre for Disease Control and Prevention said the further global spread of the virus was likely.

“All the fatalities have so far been contained to mainland China, however, this is a rapidly developing situation and the number of deaths and the number of cases is likely to be higher than those that have been confirmed so far and I expect them to rise further,” Health Secretary Matt Hancock told the British parliament.

(Reporting by Yawen Chen, Se Young Lee, Sophie Yu and Gabriel Crossley in Beijing, Sam Shen and Engen Tham in Shanghai, Ben Blanchard in Taiwan, Alison Lui and Donny Kwok in Hong Kong, John Geddie and Aradhana Aravindan in Singapore, Stephanie Nebehay in Geneva, Kate Kelland and Elizabeth Howcroft in London; Writing by Michael Perry; Editing by Stephen Coates and Clarence Fernandez and Alison Williams)

World must prepare for inevitable next flu pandemic, WHO says

FILE PHOTO: A logo is pictured on the World Health Organization (WHO) headquarters in Geneva, Switzerland, November 22, 2017. REUTERS/Denis Balibouse

By Kate Kelland

LONDON (Reuters) – The world will inevitably face another pandemic of flu and needs to prepare for the potential devastation that could cause, and not underestimate the risks, the World Health Organization (WHO) said on Monday.

Outlining a global plan to fight the viral disease and get ahead of a potential global outbreak, the WHO said the next influenza pandemic “is a matter of when not if”.

“The threat of pandemic influenza is ever-present,” Tedros Adhanom Ghebreyesus, the WHO’s director-general, said in a statement. “We must be vigilant and prepared; the cost of a major influenza outbreak will far outweigh the price of prevention.”

The world’s last flu pandemic was caused by the H1N1 virus, which spread around the world in 2009 and 2010. Studies of that pandemic found that at least one in five people worldwide were infected in the first year, and the death rate was 0.02 percent.

Global health experts and the WHO warn there is a risk that a more deadly flu virus will one day jump from animals to people, mutate and infect many hundreds of thousands of people.

Flu viruses are multiple and ever-changing, and they infect around a billion people every year around the world in seasonal outbreaks. Of those infections, around 3 to 5 million are severe cases, leading to between 290,000 and 650,000 seasonal flu-related respiratory deaths.

Vaccines can help prevent some cases, and the WHO recommends annual vaccination – especially for people working in health care and for vulnerable people such as the old, the very young and people with underlying illness.

The WHO plan – which it described as its most comprehensive to date – includes measures to try to protect populations as much as possible from annual outbreaks of seasonal flu, as well as prepare for a pandemic.

Its two main goals, the WHO said, are to improve worldwide capacities for surveillance and response – by urging all governments to develop a national flu plan, and to develop better tools to prevent, detect, control and treat flu, such as more effective vaccines and antiviral drugs.

(Reporting by Kate Kelland, editing by Gareth Jones)