This image shows one of the human fetal tissue-derived minibrains, with stem cells (gray) surrounding nerve cells (color-coded from pink to yellow, depending on their depth relative to the outside of the minibrain). (Image credit: Princess Máxima Center, Hubrecht Institute/B Artegiani, D Hendriks, H Clevers)
Romans 1:21-22, 29 For although they knew God, they neither glorified him as God nor gave thanks to him, but their thinking became futile and their foolish hearts were darkened. 22 Although they claimed to be wise, they became fools 23 and exchanged the glory of the immortal God for images made to look like a mortal human being and birds and animals and reptiles… 29 They have become filled with every kind of wickedness, evil, greed and depravity. They are full of envy, murder, strife, deceit and malice.
Important Takeaways:
- For the first time, scientists have grown cerebral organoids — three-dimensional, lab-grown “minibrains” — from human fetal brain tissue.
- The new organoids grew to the size of a grain of rice and contained many types of cells that self-organized into complex 3D structures. The researchers also triggered the growth of brain tumors within the minibrains and tested the tumors’ response to existing cancer drugs.
- To make the new minibrains, the researchers took samples of brain tissue from deceased fetuses around the gestational age of 12 to 15 weeks old, which had been provided by anonymous donors. They separately grew small samples of each of the tissues on small plates using specific nutrients and growth factors. Each sample was continuously shaken as it grew, to ensure that all the cells within them were exposed to these chemicals, and they were not provided any physical scaffolding to grow upon.
- Around four to eight days later, the researchers noticed the formation of “multiple organized 3D structures” that later matured into organoids with a “tissue-like appearance.”
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