(Reuters) – Tornadoes and thunderstorms will hit the U.S. South and Midwest for a second time this week, starting Wednesday afternoon and pushing eastward, forecasters said.

At least five people, including three children, were killed over the weekend in a storm system that drove more than three dozen tornadoes across the U.S. South.

Communities in central Texas and western Louisiana, already hit by flash floods and twisters in the first round, will be hit once more by high winds, twisters and intense rain, according to AccuWeather and the NWS.

“This is a dangerous, vigorous storm,” Jim Hayes, a meteorologist with the National Weather Service’s Weather Prediction Center in Maryland, said early Wednesday.

The storm is expected to stretch from Iowa and Missouri in the north through Kansas, Oklahoma and Texas to the south, said AccuWeather Senior Meteorologist John Feerick.

“Dallas and Oklahoma City, from there on eastward is probably at greatest threat from damaging winds, flooding downpours and tornadoes,” said Feerick.

Northern Oklahoma could be pelted with hail 2 inches (5 cm) in diameter, or larger, on Wednesday, the NWS tweeted.

NWS forecaster Hayes said the storm gets its initial fuel from warm, moist air over the Gulf of Mexico.

“It’ll kick-up this afternoon over southern Kansas and about all of Oklahoma, with rain, wind gusts of 65 mph, hail and tornadoes.”

“The worst will hit before midnight,” he added. “By early Thursday it’ll push into Kentucky and Alabama.”

As the storm tracks eastward, it will extend from Indiana south to Florida by late Thursday, hitting the Atlanta area that night and the Atlantic coast the next day.

Picking up moisture from the ocean, the system is likely to produce intense thunderstorms up the eastern seaboard as far north as New York state.

New York City, Philadelphia and Washington may face travel delays from the rain and possibly property damage from high winds, AccuWeather warned.

Flash flooding could remain a threat in Maine, New Hampshire and Massachusetts on Saturday, the weather service said.

(Reporting Andrew Hay in Taos, New Mexico and Rich McKay in Atlanta; Editing by Raissa Kasolowsky)